Results 71 to 80 of about 728 (163)

Autophagy and Cellular Senescence in Alzheimer's Disease: Key Drivers of Neurodegeneration

CNS Neuroscience &Therapeutics, Volume 31, Issue 7, July 2025.
Impaired autophagy in Alzheimer's disease leads to accumulation of amyloid‐β and tau aggregates, while senescent brain cells secrete pro‐inflammatory SASP factors. The interplay between defective clearance and chronic inflammation accelerates neuronal dysfunction and highlights autophagy enhancers and senolytics as promising therapeutic strategies ...
Md Sadique Hussain, Neetu Agrawal, Baby Ilma, Rekha M M, Priya Priyadarshini Nayak, Mandeep Kaur, Anil Khachi, Kavita Goyal, Arcot Rekha, Saurabh Gupta, Gaurav Gupta, Kamal Dua   +11 more
wiley   +1 more source

Accelerated Cellular Senescence in Progressive Multiple Sclerosis: A Histopathological Study

Annals of Neurology, Volume 97, Issue 6, Page 1074-1087, June 2025.
Objective The neurodegenerative processes driving the build‐up of disability in progressive multiple sclerosis (P‐MS) have not been fully elucidated. Recent data link cellular senescence (CS) to neurodegeneration. We investigated for evidence of CS in P‐MS and sought to determine its pattern.
Dimitrios Papadopoulos, Roberta Magliozzi, Sara Bandiera, Ilaria Cimignolo, Elena Barusolo, Lesley Probert, Vassilis Gorgoulis, Richard Reynolds, Richard Nicholas   +8 more
wiley   +1 more source

Targeting ATF6α Attenuates UVB‐Induced Senescence and Improves Skin Homeostasis by Regulating IL8 Expression

Aging Cell, Volume 24, Issue 6, June 2025.
UVB exposure can trigger senescence in dermal fibroblasts. We show that silencing ATF6α disrupts the establishment of the UVB‐induced senescent phenotype by preventing the onset of several senescent biomarkers and altering the composition of the SASP, consequently affecting its impact on the skin microenvironment.
Joëlle Giroud, Pauline Delvaux, Laura Carlier, Clémentine De Schutter, Nathalie Martin, Raphaël Rouget, Ayeh Bolouki, Valérie De Glas, Inès Bouriez, Florent Bourdoux, Sophie Burteau, Julien Théry, Gauthier Decanter, Nicolas Penel, Yvan de Launoit, Benjamin Ledoux, Corinne Abbadie, Yves Poumay, Olivier Pluquet, Florence Debacq‐Chainiaux   +19 more
wiley   +1 more source

Targeting Senescence with Apigenin Improves Chemotherapeutic Efficacy and Ameliorates Age‐Related Conditions in Mice

Advanced Science, Volume 12, Issue 20, May 29, 2025.
As a plant‐derived flavonoid, apigenin directly targets PRDX6 to inhibit its PLA2 activity, blocking HSPA8 activation and disturbing its interactions with ATM and p38MAPK in senescent cells. By dampening wide spectrum expression of the SASP, apigenin prevents loss of tissue homeostasis, improves organ function, and alleviates multiple age‐related ...
Hongwei Zhang, Qixia Xu, Zhirui Jiang, Rong Sun, Qun Wang, Sanhong Liu, Xin Luan, Judith Campisi, James L. Kirkland, Weidong Zhang, Yu Sun   +10 more
wiley   +1 more source

Rejuvenating Hyaline Cartilage with Senescence‐Targeting Si‐ADAM19 Delivery for Osteoarthritis Therapy

Advanced Science, Volume 12, Issue 13, April 3, 2025.
ADAM19 is identified as a novel target for senescent chondrocyte rejuvenation. Knockdown of ADAM19 results in the attenuation of cellular senescence and the formation of proliferative extracellular matrix‐synthesizing chondrocytes. senHMSN_si‐ADAM19 can target deliver therapeutic siRNA into senescent cells and rejuvenate hyaline cartilage in ...
Jiasheng Wang, Peng Guo, Dongmei Wu, Junzhi Yi, Qi Jiang, Jiajie Hu, Hongwei Ouyang   +6 more
wiley   +1 more source

Fisetin as a Blueprint for Senotherapeutic Agents – Elucidating Geroprotective and Senolytic Properties with Molecular Modeling

Chemistry – A European Journal, Volume 31, Issue 16, March 17, 2025.
The exceptional senotherapeutic activity of fisetin, combining both geroprotective and senolytic effects, was validated using computational chemistry tools, establishing it as a cornerstone template for the development of novel agents. Abstract Targeting senescent cells and the factors that accelerate this pathological state has recently emerged as a ...
Maciej Spiegel
wiley   +1 more source

From Lasers to Longevity: Exploring Energy-Based Devices as Senotherapeutic Tools in Dermatology

Cosmetics
Background: Cutaneous aging is a multifactorial process, increasingly understood through the lens of cellular senescence, a state of stable cell cycle arrest accompanied by a pro-inflammatory secretory phenotype that disrupts tissue homeostasis.
Oana Mihaela Condurache Hrițcu, Victor-Vlad Costan, Ștefan Vasile Toader, Daciana Elena Brănișteanu, Mihaela Paula Toader   +4 more
doaj   +1 more source

New Horizons in Myotonic Dystrophy Type 1: Cellular Senescence as a Therapeutic Target

BioEssays, Volume 47, Issue 3, March 2025.
Cellular senescence accumulates in the skeletal muscle of patients with myotonic dystrophy Type 1, leading to the production of senescence‐associated secretory phenotype (SASP) factors that have detrimental effects. Targeting these senescent cells with senotherapeutics could restore muscle homeostasis and slow disease progression.
Cécilia Légaré, J. Andrew Berglund, Elise Duchesne, Nicolas A. Dumont   +3 more
wiley   +1 more source

Senotherapeutic Potential of Araliadiol in Senescent Human Dermal Fibroblasts: An In Vitro Study Using Three Senescence Models

Pharmaceutics
Background/Objectives: With the rapid aging of the global population, the interest in therapies for age-related diseases has increased substantially. The skin is particularly important, as aging-related changes are visible and negatively impact quality ...
Seokmuk Park, Seyeol Baek, Hee-Jae Shin, Jeong Yi Hwang, Dae Sung Yoo, Dae Bang Seo, Seunghee Bae   +6 more
doaj   +1 more source

Cellular Senescence: Defining a Path Forward.

Cell, 2019
Cellular senescence is a cell state implicated in various physiological processes and a wide spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence to improve healthy aging and age-related disease, otherwise known as
V. Gorgoulis, P. Adams, A. Alimonti, D. Bennett, O. Bischof, C. Bishop, J. Campisi, M. Collado, K. Evangelou, G. Ferbeyre, Jesús Gil, E. Hara, V. Krizhanovsky, D. Jurk, A. Maier, M. Narita, L. Niedernhofer, J. Passos, P. Robbins, C. Schmitt, J. Sedivy, K. Vougas, T. von Zglinicki, Daohong Zhou, M. Serrano, M. Demaria   +25 more
semanticscholar   +1 more source