Results 81 to 90 of about 728 (163)

Editorial: The Role of Cellular Senescence in Health and Disease

Frontiers in Cellular Neuroscience, 2022
Ignacio Palmero, Vassilis Gorgoulis, Vassilis Gorgoulis, Vassilis Gorgoulis, Vassilis Gorgoulis, Vassilis Gorgoulis, Isabel Varela-Nieto, Isabel Varela-Nieto, Isabel Varela-Nieto   +8 more
doaj   +1 more source

The Dynamic Process and Its Dual Effects on Tumors of Therapy-Induced Senescence

Cancer Management and Research, 2020
Chenxi Liao,1,* Yin Xiao,2,* Lingbo Liu1 1Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People’s Republic of China; 2Cancer Center, Union Hospital, Tongji Medical ...
Liao C, Xiao Y, Liu L
doaj  

Senescence and senotherapies in pediatric biliary cirrhosis

, 2023
Premature senescence worsens the prognosis of adult chronic hepatobiliary diseases and some evidence suggests that this phenomenon also occurs in biliary atresia, which is the leading cause of pediatric liver transplantation. Since alternatives to liver transplantation are still lacking, the aim of our work was to investigate premature senescence in ...
openaire   +1 more source

Connecting epigenetics and inflammation in vascular senescence: state of the art, biomarkers and senotherapeutics

Frontiers in Genetics
Vascular diseases pose major health challenges, and understanding their underlying molecular mechanisms is essential to advance therapeutic interventions. Cellular senescence, a hallmark of aging, is a cellular state characterized by cell-cycle arrest, a
Oscar Fraile-Martinez, Oscar Fraile-Martinez, Diego De Leon-Oliva, Diego De Leon-Oliva, Diego Liviu Boaru, Diego Liviu Boaru, Patricia De Castro-Martinez, Patricia De Castro-Martinez, Cielo Garcia-Montero, Cielo Garcia-Montero, Silvestra Barrena-Blázquez, Silvestra Barrena-Blázquez, Joaquin García-García, Natalio García-Honduvilla, Natalio García-Honduvilla, Melchor Alvarez-Mon, Melchor Alvarez-Mon, Melchor Alvarez-Mon, Melchor Alvarez-Mon, Laura Lopez-Gonzalez, Laura Lopez-Gonzalez, Raul Diaz-Pedrero, Raul Diaz-Pedrero, Raul Diaz-Pedrero, Luis G. Guijarro, Luis G. Guijarro, Luis G. Guijarro, Luis G. Guijarro, Miguel A. Ortega, Miguel A. Ortega, Miguel A. Ortega, Miguel A. Ortega   +31 more
doaj   +1 more source

The autophagy-senescence axis as a threshold model of aging and therapeutic targeting

Redox Biology
Autophagy and cellular senescence are fundamental stress-response programs that critically shape aging and disease progression, yet their functional relationship has remained paradoxical. Autophagy is traditionally viewed as a cytoprotective process that
Md Entaz Bahar, Jin Seok Hwang, Trang Huyen Lai, Kazi-Marjahan Akter, Rizi Firman Maulidi, Deok Ryong Kim   +5 more
doaj   +1 more source

Adoptive NK cell therapy: a potential revolutionary approach in longevity therapeutics

Immunity & Ageing
The aging process intricately involves immune system dynamics, with a crucial role in managing senescent cells (SNCs) and their senescence-associated secretory phenotypes (SASPs).
Xuewen Deng, Hiroshi Terunuma
doaj   +1 more source

Targeting pathological cells with senolytic drugs reduces seizures in neurodevelopmental mTOR-related epilepsy

Nature Neuroscience
Cortical malformations such as focal cortical dysplasia type II (FCDII) are associated with pediatric drug-resistant epilepsy that necessitates neurosurgery. FCDII results from somatic mosaicism due to post-zygotic mutations in genes of the PI3K-AKT-mTOR
Théo Ribierre, Alexandre Bacq, Florian Donneger, M. Doladilhe, Marina Maletic, D. Roussel, Isabelle Le Roux, F. Chassoux, Bertrand Devaux, Homa Adle-Biassette, S. Ferrand-Sorbets, G. Dorfmüller, M. Chipaux, S. Baldassari, J. Poncer, S. Baulac   +15 more
semanticscholar   +1 more source

Effects of Administration and Intensity of Statins on Mortality in Patients Undergoing Hemodialysis

Pharmaceuticals
(1) Background: Few studies have investigated the association between the intensity of statins and patient survival rates in patients undergoing hemodialysis (HD) as primary outcomes.
Yunmee Lho, Gui Ok Kim, Bo Yeon Kim, Eun Jung Son, Seok Hui Kang   +4 more
doaj   +1 more source

P21/P16 Senescence Heterogeneity In Diabetic Bone

International Dental Journal
Aim or purpose: To investigate bone compartment-specific senescence heterogeneity in type 2 diabetic mice, focusing on spatiotemporal p16/p21 expression patterns and differential efficacy of senolytic therapies.
Jiayu Yan, Jiaying Shi, Ruowen Zhao, Junhua Wu, Siyi Chen   +4 more
doaj   +1 more source

Targeting cellular senescence in kidney diseases and aging: A focus on mesenchymal stem cells and their paracrine factors

Cell Communication and Signaling
Cellular senescence is a phenomenon distinguished by the halting of cellular division, typically triggered by DNA injury or numerous stress-inducing factors.
Seyyedeh Mina Hejazian, Seyyed Sina Hejazian, Seyyedeh Mina Mostafavi, Seyed Mahdi Hosseiniyan, Soheila Montazersaheb, Mohammadreza Ardalan, Sepideh Zununi Vahed, Abolfazl Barzegari   +7 more
doaj   +1 more source