Results 41 to 50 of about 26,464 (199)

Deeper understanding of mechanisms contributing to sepsis-induced myocardial dysfunction [PDF]

Critical Care, 2014
AbstractThe inflammatory response of sepsis results in organ dysfunction, including myocardial dysfunction. Myocardial dysfunction is particularly important in patients with severe septic shock who progress to a hypodynamic pre-terminal phase. Multiple aspects of this septic inflammatory response contribute to the pathogenesis of decreased ventricular ...
openaire   +3 more sources

Growth Differentiation Factor-15 Deficiency Augments Inflammatory Response and Exacerbates Septic Heart and Renal Injury Induced by Lipopolysaccharide

Scientific Reports, 2017
Septic acute kidney injury (AKI) and myocardial dysfunction are leading causes of mortality with no accepted method of therapy. In this study we demonstrate the role of growth differentiating factor 15 (GDF15) in septic AKI and myocardial dysfunction ...
Palida Abulizi, Neruja Loganathan, Duo Zhao, Tina Mele, Yixin Zhang, Terry Zwiep, Kexiang Liu, Xiufen Zheng   +7 more
doaj   +1 more source

IL-6/STAT3 Signaling Promotes Cardiac Dysfunction by Upregulating FUNDC1-Dependent Mitochondria-Associated Endoplasmic Reticulum Membranes Formation in Sepsis Mice

Frontiers in Cardiovascular Medicine, 2022
AimsCytokine storm is closely related to the initiation and progression of sepsis, and the level of IL-6 is positively correlated with mortality and organ dysfunction.
Tao Jiang, Dewei Peng, Wei Shi, Junyi Guo, Shengqi Huo, Lintong Men, Cuntai Zhang, Sheng Li, Jiagao Lv, Li Lin   +9 more
doaj   +1 more source

Sepsis causes right ventricular myocardial inflammation independent of pulmonary hypertension in a porcine sepsis model.

PLoS ONE, 2019
INTRODUCTION:Right ventricular (RV) myocardial dysfunction is a common feature in septic shock. It can worsen outcome, but the etiology is poorly understood.
Soeren Erik Pischke, Siv Hestenes, Harald Thidemann Johansen, Hilde Fure, Jan Frederik Bugge, Andreas Espinoza, Helge Skulstad, Thor Edvardsen, Erik Fosse, Tom Eirik Mollnes, Per Steinar Halvorsen, Erik Waage Nielsen   +11 more
doaj   +1 more source

Evaluating the therapeutic effects of creatine phosphate administration in sepsis-induced myocardial dysfunction. [PDF]

Medicine (Baltimore)
The objective of this study is to investigate the involvement of creatine phosphate (CP) in sepsis-induced myocardial dysfunction (SIMD) among patients. A retrospective analysis was conducted to gather data on patients with SIMD. Based on the administration of CP, the patients were categorized into 2 groups: the observation group and the control group.
Shi L, Ye G.
europepmc   +3 more sources

Inhibition of miR-155 Protects Against LPS-induced Cardiac Dysfunction and Apoptosis in Mice

Molecular Therapy: Nucleic Acids, 2016
Sepsis-induced myocardial dysfunction represents a major cause of death in intensive care units. Dysregulated microRNAs (miR)-155 has been implicated in multiple cardiovascular diseases and miR-155 can be induced by lipopolysaccharide (LPS). However, the
Hui Wang, Yihua Bei, Peipei Huang, Qiulian Zhou, Jing Shi, Qi Sun, Jiuchang Zhong, Xinli Li, Xiangqing Kong, Junjie Xiao   +9 more
doaj   +1 more source

Extremely high troponin levels induced by septic shock: a case report

Journal of Medical Case Reports, 2021
Background Troponin levels can be elevated in various diseases other than acute myocardial infarction, including sepsis. In diseases without myocardial necrosis, the elevated troponin levels are relatively low and normalize quickly.
Naoki Matsunaga, Yuki Yoshioka, Yasushi Fukuta   +2 more
doaj   +1 more source

Septic cardiomyopathy: Diagnosis and management

Journal of Intensive Medicine, 2022
There is an extensive body of literature focused on sepsis-induced myocardial dysfunction, but results are conflicting and no objective definition of septic cardiomyopathy (SCM) has been established.
Florence Boissier, Nadia Aissaoui
doaj   +1 more source

Sepsis-Induced Myocardial Depression and Takotsubo Syndrome

Türk Yoğun Bakim Derneği Dergisi, 2015
Sepsis induced temporary myocardial dysfunction characterized as impairment of myocardial contraction is an important cause of mortality and morbidity in intensive care units.
Mustafa Kemal Arslantaş, Gülbin Töre Altun, İsmail Cinel   +2 more
doaj   +1 more source

Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function

Advanced Science, EarlyView.
This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang, Wenxuan Zhao, Xiaoming Hu, Yishu Wang, Peidong Yang, Diwei Zheng, Yugang Wang, Guanghui Ma, Min Shi, Wei Wei, Shuang Wang   +10 more
wiley   +1 more source