Results 31 to 40 of about 26,464 (199)

Roles of autophagy in sepsis-induced myocardial dysfunction: a comprehensive review. [PDF]

Am J Transl Res
Zheng X, Chen H.
europepmc   +3 more sources

Paeoniflorin and Hydroxysafflor Yellow A in Xuebijing Injection Attenuate Sepsis-Induced Cardiac Dysfunction and Inhibit Proinflammatory Cytokine Production

Frontiers in Pharmacology, 2021
Sepsis-induced myocardial dysfunction is a major contributor to the poor outcomes of septic shock. As an add-on with conventional sepsis management for over 15 years, the effect of Xuebijing injection (XBJ) on the sepsis-induced myocardial dysfunction ...
Xin-Tong Wang, Xin-Tong Wang, Zhen Peng, Zhen Peng, Ying-Ying An, Ying-Ying An, Ting Shang, Ting Shang, Guangxu Xiao, Guangxu Xiao, Shuang He, Shuang He, Xi Chen, Han Zhang, Yuefei Wang, Tao Wang, Jun-Hua Zhang, Xiumei Gao, Yan Zhu, Yan Zhu, Yuxin Feng, Yuxin Feng   +21 more
doaj   +1 more source

Regulatory role of the TLR4/JNK signaling pathway in sepsis‑induced myocardial dysfunction. [PDF]

Mol Med Rep, 2021
Sepsis is a life‑threatening organ dysfunction caused by a dysregulated host response to infection, and is a leading cause of mortality worldwide. Myocardial dysfunction is associated with poor prognosis in patients with sepsis and contributes to a high risk of mortality.
Chang C, Hu L, Sun S, Song Y, Liu S, Wang J, Li P.   +6 more
europepmc   +4 more sources

Levosimendan as a new force in the treatment of sepsis-induced cardiomyopathy: mechanism and clinical application

Journal of International Medical Research, 2019
The heart is one of the organs most vulnerable to sepsis. This review describes the general characteristics of sepsis-induced cardiomyopathy and the main pathogenesis of myocardial dysfunction in sepsis.
Fei Yang, Li Na Zhao, Yi Sun, Zhuang Chen   +3 more
doaj   +1 more source

Myocardial dysfunction in sepsis

Journal of Pediatric Critical Care, 2018
Septic shock is a major cause of mortality in children. Myocardial dysfunction in severe sepsis and septic shock is well recognized but its pathogenesis could be multifactorial.
Lokesh Tiwari, Jyoti Chaturvedi, Chhitiz Anand   +2 more
doaj   +1 more source

Mitophagy coordinates the mitochondrial unfolded protein response to attenuate inflammation-mediated myocardial injury

Redox Biology, 2021
Mitochondrial dysfunction is a fundamental challenge in septic cardiomyopathy. Mitophagy and the mitochondrial unfolded protein response (UPRmt) are the predominant stress-responsive and protective mechanisms involved in repairing damaged mitochondria ...
Yue Wang, Heinrich Jasper, Sam Toan, David Muid, Xing Chang, Hao Zhou   +5 more
doaj   +1 more source

Role of TXNIP/NLRP3 in sepsis-induced myocardial dysfunction

International Journal of Molecular Medicine, 2019
Myocardial injury is one of the main symptoms of sepsis. However, the mechanisms underlying sepsis‑induced myocardial dysfunction remain unclear. In the present study, the concentration of cardiac troponin T (CTnT) in serum was measured using an enzyme‑linked immunosorbent assay kit.
Yang, Chun, Xia, Wan, Liu, Xiaolin, Lin, Jian, Wu, Aiping   +4 more
openaire   +3 more sources

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

ELUCIDATING THE ROLE OF REVERSIBLE PROTEIN PHOSPHORYLATION IN SEPSIS-INDUCED MYOCARDIAL DYSFUNCTION [PDF]

Shock, 2009
Mortality in children with sepsis is most often related to diminished cardiac output with cardiovascular collapse, resulting in impaired oxygen delivery and, ultimately, end-organ failure. Although cardiovascular "collapse" is commonly observed in individuals with septic shock, the hemodynamic causes of this differ greatly.
Angela, Lorts, Timothy, Burroughs, Thomas P, Shanley   +2 more
openaire   +2 more sources

Role of the mTOR Signalling Pathway in Human Sepsis-Induced Myocardial Dysfunction [PDF]

Canadian Journal of Cardiology, 2019
Sepsis-induced myocardial dysfunction (SIMD) is a life-threatening complication of sepsis. Mammalian target of rapamycin (mTOR) signalling pathway is significantly associated with SIMD in an animal model; however, there have been no clinical studies of the association in humans.We enrolled 88 patients with sepsis who were admitted to the intensive care
Wei, Cheng Mm, Yun, Long, Hao, Wang, Wen, Han Mm, Jiahui, Zhang, Na, Cui   +5 more
openaire   +2 more sources