Results 21 to 30 of about 26,464 (199)

Cardiac Metabolism in Sepsis

Metabolites, 2021
The mechanism of sepsis-induced cardiac dysfunction is believed to be different from that of myocardial ischemia. In sepsis, chemical mediators, such as endotoxins, cytokines, and nitric oxide, cause metabolic abnormalities, mitochondrial dysfunction ...
Satoshi Kawaguchi, Motoi Okada
doaj   +1 more source

Sepsis-induced myocardial dysfunction: pathophysiology and management [PDF]

Journal of Intensive Care, 2016
Sepsis is aggravated by an inappropriate immune response to invading microorganisms, which occasionally leads to multiple organ failure. Several lines of evidence suggest that the ventricular myocardium is depressed during sepsis with features of diastolic dysfunction.
Kakihana, Yasuyuki, Ito, Takashi, Nakahara, Mayumi, Yamaguchi, Keiji, Yasuda, Tomotsugu   +4 more
openaire   +2 more sources

A bibliometric analysis of sepsis-induced myocardial dysfunction from 2002 to 2022. [PDF]

Front Cardiovasc Med, 2023
BackgroundSepsis-induced myocardial dysfunction (SIMD) has a significant contribution to sepsis-caused death in critically ill patients. In recent years, the number of published articles related to SIMD has increased rapidly. However, there was no literature that systematically analyzed and evaluated these documents.
Yao H, Liu S, Zhang Z, Xiao Z, Li D, Yi Z, Huang Y, Zhou H, Yang Y, Zhang W.   +9 more
europepmc   +4 more sources

KIF13B Attenuates Sepsis-Induced Myocardial Dysfunction through the Stabilization of PLIN5. [PDF]

Research (Wash D C)
Sepsis-induced cardiac dysfunction (SICD) is a major contributor to mortality in sepsis. Kinesin family member 13B (KIF13B) has been identified as a critical protective factor for metabolic disorder and cardiovascular disease; however, the role of KIF13B in SICD remains unknown.
Zhang L, Miao G, Mei S, Han Y, Xu Y, Zhang W, Chen J, Lu K, Zhao Y, Zhou Z, Chen J, Guo J, Lai P, Lam SM, Shui G, Zhang L, Zhang W, Huang W, Wang Y, Xian X.   +19 more
europepmc   +3 more sources

Il12a Deletion Aggravates Sepsis-Induced Cardiac Dysfunction by Regulating Macrophage Polarization

Frontiers in Pharmacology, 2021
Cardiac dysfunction is a well-recognized complication of sepsis and is associated with the outcome and prognosis of septic patients. Evidence suggests that Il12a participates in the regulation of various cardiovascular diseases, including heart failure ...
Zhen Wang, Zhen Wang, Zhen Wang, Menglin Liu, Di Ye, Di Ye, Di Ye, Jing Ye, Jing Ye, Jing Ye, Menglong Wang, Menglong Wang, Menglong Wang, Jianfang Liu, Jianfang Liu, Jianfang Liu, Yao Xu, Yao Xu, Yao Xu, Jishou Zhang, Jishou Zhang, Jishou Zhang, Mengmeng Zhao, Mengmeng Zhao, Mengmeng Zhao, Yongqi Feng, Yongqi Feng, Yongqi Feng, Shuwan Xu, Shuwan Xu, Shuwan Xu, Wei Pan, Wei Pan, Wei Pan, Zhen Luo, Zhen Luo, Zhen Luo, Dan Li, Jun Wan, Jun Wan, Jun Wan   +40 more
doaj   +1 more source

Current insight on the mechanisms of programmed cell death in sepsis-induced myocardial dysfunction. [PDF]

Front Cell Dev Biol, 2023
Sepsis is a clinical syndrome characterized by a dysregulated host response to infection, leading to life-threatening organ dysfunction. It is a high-fatality condition associated with a complex interplay of immune and inflammatory responses that can cause severe harm to vital organs. Sepsis-induced myocardial injury (SIMI), as a severe complication of
Liu AB, Li SJ, Yu YY, Zhang JF, Ma L.
europepmc   +4 more sources

Natural products as multi‑target therapies for sepsis‑induced myocardial dysfunction (Review). [PDF]

Int J Mol Med
Sepsis, an infection‑triggered systemic inflammatory response syndrome, ranks as the third leading cause of death worldwide due to its high incidence and mortality. Sepsis‑induced myocardial dysfunction (SIMD) is a frequent and serious complication that notably increases patient morbidity and mortality. The underlying pathophysiology of SIMD involves a
Tang F, Liu D, Zhu SC, Zhou HM, Qiu XW.
europepmc   +3 more sources

Pterostilbene Interferes With Lipopolysaccharide-Induced Myocardial Injury Through Oxidative Stress and Inflammasome Pathways

Frontiers in Physiology, 2022
Myocardial contractile dysfunction caused by sepsis is a serious threat to human health, and its pathogenesis is not completely clear. It is generally believed that excessive inflammation and oxidative stress are the main causes of myocardial damage ...
Lei Zhang, Xiao Jian, Jiachuan Yu, Jian Yu   +3 more
doaj   +1 more source

Cardioprotective Effect of Tangeretin by Inhibiting PTEN/AKT/mTOR Axis in Experimental Sepsis-Induced Myocardial Dysfunction

Molecules, 2020
Sepsis aggregates undesirable immune response causing depression of ventricular myocardium and diastolic dysfunction. This present study examined the effect of a plant-derived flavone tangeretin (TG) on autophagy and reduction in myocardial dysfunction ...
Predeepkumar Narayanappa Shiroorkar, Obaid Afzal, Imran Kazmi, Fahad A. Al-Abbasi, Abdulmalik Saleh Alfawaz Altamimi, Kumar Shiva Gubbiyappa, Nagaraja Sreeharsha   +6 more
doaj   +1 more source

Pathological roles of ubiquitination and deubiquitination systems in sepsis-induced myocardial dysfunction. [PDF]

Biomol Biomed
Sepsis-induced myocardial dysfunction (SIMD) is a severe complication of sepsis, characterized by impaired cardiac function and high mortality rates. Despite significant advances in understanding sepsis pathophysiology, the molecular mechanisms underlying SIMD remain incompletely elucidated.
Wang Z, Sun S, Huang L, Chen X, Xu H, Ma H, Xiao M, Wang L.   +7 more
europepmc   +4 more sources