iCDA-CGR: Identification of circRNA-disease associations based on Chaos Game Representation.
PLoS Computational Biology, 2020 Found in recent research, tumor cell invasion, proliferation, or other biological processes are controlled by circular RNA. Understanding the association between circRNAs and diseases is an important way to explore the pathogenesis of complex diseases ...
Kai Zheng +5 more
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Detection of Bacillus anthracis DNA in complex soil and air samples using next-generation sequencing. [PDF]
PLoS ONE, 2013 Bacillus anthracis is the potentially lethal etiologic agent of anthrax disease, and is a significant concern in the realm of biodefense. One of the cornerstones of an effective biodefense strategy is the ability to detect infectious agents with a high ...
Nicholas A Be +9 more
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C-terminal substitution of HBV core proteins with those from DHBV reveals that arginine-rich 167RRRSQSPRR175 domain is critical for HBV replication. [PDF]
PLoS ONE, 2012 To investigate the contributions of carboxyl-terminal nucleic acid binding domain of HBV core (C) protein for hepatitis B virus (HBV) replication, chimeric HBV C proteins were generated by substituting varying lengths of the carboxyl-terminus of duck ...
Jaesung Jung +8 more
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Zhongguo gonggong weisheng, 2022 ObjectiveTo conduct a gene tracing-based analysis on a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive oropharyngeal swab specimen from a suspected coronavirus disease 2019 (COVID-19) case without epidemiologically-confirmed ...
Wen-jun XIE, Heng CHEN, Jing FENG
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A new method for mapping nucleic acid sequence homology by electron microscopy
Nucleic Acids Research, 1975 We describe here a new method for the electron microscopic mapping of sequence homology in nucleic acids. Specific segments of the T7 chromosome have been isolated following digestion with the restriction endonuclease from Hemophilus aegyptious (Haey).
M D, Bick, C A, Thomas
openaire +3 more sources
, 2010 Pur-α is a nucleic acid-binding protein involved in cell cycle control, transcription, and neuronal function. Initially no prediction of the three-dimensional structure of Pur-α was possible.
Graebsch, Almut +4 more
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Improving Precise Genome Editing Using Donor DNA/gRNA Hybrid Duplex Generated by Complementary Bases
Biomolecules, 2022 In precise genome editing, site-specific DNA double-strand breaks (DSBs) induced by the CRISPR/Cas9 system are repaired via homology-directed repair (HDR) using exogenous donor DNA templates.
Wataru Aiba +3 more
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Nucleic acid sequences of the oncogene v-rel in reticuloendotheliosis virus strain T and its cellular homolog, the proto-oncogene c-rel [PDF]
Journal of Virology, 1984 Reticuloendotheliosis virus strain T (Rev-T) is a highly oncogenic replication-defective retrovirus which contains the oncogene v-rel. It is thought that Rev-T arose when a virus similar to Rev-A, the helper virus of Rev-T, infected a turkey and recombined with c-rel from that turkey.
K C, Wilhelmsen, K, Eggleton, H M, Temin
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Who Watches the Watchmen? An Appraisal of Benchmarks for Multiple Sequence Alignment [PDF]
, 2012 Multiple sequence alignment (MSA) is a fundamental and ubiquitous technique in bioinformatics used to infer related residues among biological sequences. Thus alignment accuracy is crucial to a vast range of analyses, often in ways difficult to assess in ...
A Löytynoja +49 more
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Analysis and forecasting of global real time RT-PCR primers and probes for SARS-CoV-2
Scientific Reports, 2021 Rapid tests for active SARS-CoV-2 infections rely on reverse transcription polymerase chain reaction (RT-PCR). RT-PCR uses reverse transcription of RNA into complementary DNA (cDNA) and amplification of specific DNA (primer and probe) targets using ...
Gowri Nayar +6 more
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