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Sequestosome 1/p62 enhances chronic skin inflammation [PDF]
Journal of Allergy and Clinical Immunology, 2021 The molecular control of inflammation and epidermal thickening in skin lesions of patients with atopic dermatitis (AD) is not known. Sequestosome 1/p62 is a multifunctional adapter protein implicated in the control of key regulators of cellular homeostasis, such as proinflammatory and mechanistic target of rapamycin signaling.We sought to determine ...
Peter Petzelbauer +2 more
exaly +4 more sources
Enhanced neointimal hyperplasia and carotid artery remodelling in sequestosome 1 deficient mice [PDF]
Journal of Cellular and Molecular Medicine, 2010 AbstractDeficiency in the signal adaptor protein sequestosome 1 (SQSTM1/A170/p62) in mice is associated with mature‐onset obesity, accompanied by insulin and leptin resistance. We previously established that redox sensitive transcription factor Nrf2 up‐regulates SQSTM1 expression in response to atherogenic stimuli or laminar shear stress in vascular ...
Giovanni E Mann +2 more
exaly +5 more sources
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The sequestosome 1 protein: therapeutic vulnerabilities in ovarian cancer
Clinical and Translational Oncology, 2023Ovarian cancer (OC) is the most deadly tumor that may develop in a woman's reproductive system. It is also one of the most common causes of death among those who have been diagnosed with cancer in women. An adapter protein known as sequestosome 1(SQSTM1) or p62 is primarily responsible for the transportation, degradation, and destruction of a wide ...
Maryam Nurzadeh +3 more
openaire +2 more sources
The Presence of the Autophagic Markers LC3B and Sequestosome 1/p62 in the Hydatidiform Mole
International Journal of Gynecological Pathology, 2022Autophagy is implicated in normal pregnancy and various pathologic pregnancy conditions. Its presence in hydatidiform moles (HM) is unknown. We immunohistochemically studied 36 HM for LC3B and p62 to precisely determine their expression in the decidua, endometrium, and villi. Nineteen nonmolar pregnancies were also studied.
Karpathiou, Georgia +6 more
openaire +2 more sources