Results 131 to 140 of about 10,790 (159)

Cytosolic overexpression of p62 sequestosome 1 in neoplastic prostate tissue

Histopathology, 2005
Aims : To investigate the expression of p62 in various prostatic tissues, and to demonstrate different immunohistochemical patterns of p62 expression in distinct pathological entities of the prostate. The p62 sequestosome 1 (SQSTM1) gene product is a multifunctional protein with ubiquitous expression in normal adult tissue.Methods and results ...
H, Kitamura, T, Torigoe, H, Asanuma, S-I, Hisasue, K, Suzuki, T, Tsukamoto, M, Satoh, N, Sato   +7 more
openaire   +2 more sources

Sequestosome 1/p62 shuttles polyubiquitinated tau for proteasomal degradation

Journal of Neurochemistry, 2005
AbstractInclusions isolated from several neurodegenerative diseases, including Alzheimer's disease (AD), are characterized by ubiquitin‐positive proteinaceous aggregates. Employing confocal and immunoelectron microscopy, we find that the ubiquitin‐associating protein sequestosome1/p62, co‐localizes to aggregates isolated from AD but not control brain ...
Jeganathan Ramesh, Babu, Thangiah, Geetha, Marie W, Wooten   +2 more
openaire   +2 more sources

Enhanced neointimal hyperplasia and carotid artery remodelling in sequestosome 1 deficient mice [PDF]

Journal of Cellular and Molecular Medicine, 2010
AbstractDeficiency in the signal adaptor protein sequestosome 1 (SQSTM1/A170/p62) in mice is associated with mature‐onset obesity, accompanied by insulin and leptin resistance. We previously established that redox sensitive transcription factor Nrf2 up‐regulates SQSTM1 expression in response to atherogenic stimuli or laminar shear stress in vascular ...
Toru Yanagawa, Noriko Noguchi, Richard C M Siow   +2 more
exaly   +4 more sources

Sequestosome 1/p62-related pathways as therapeutic targets in hepatocellular carcinoma

Expert Opinion on Therapeutic Targets, 2019
Protein sequestosome 1/p62 (p62) plays a crucial role in vital complex and interacting signaling pathways in normal and neoplastic cells. P62 is involved in autophagy, defense against oxidative stress via activation of the Keap1/Nrf2 system, in protein aggregation and sequestration, and in apoptosis.
Helmut Denk, Conny Stumptner, Peter M. Abuja, Kurt Zatloukal   +3 more
openaire   +2 more sources

Characterization and chemical modulation of p62/SQSTM1/Sequestosome-1 as an autophagic N-recognin

2023
In the Arg/N-degron pathway, single N-terminal (Nt) residues function as N-degrons recognized by UBR box-containing N-recognins that induce substrate ubiquitination and proteasomal degradation. Recent studies led to the discovery of the autophagic Arg/N-degron pathway, in which the autophagic receptor p62/SQSTM1/Sequestosome-1 acts as an N-recognin ...
Su Jin, Lee, Hye Yeon, Kim, Min Ju, Lee, Su Bin, Kim, Yong Tae, Kwon, Chang Hoon, Ji   +5 more
openaire   +2 more sources

Biology of p62/sequestosome-1 in Age-Related Macular Degeneration (AMD)

2015
p62/sequestosome-1 is a multidimensional protein that interacts with many signaling factors, and regulates a variety of cellular functions including inflammation, apoptosis, and autophagy. Our previous work has revealed in the retinal pigment epithelium (RPE) that p62 promotes autophagy and simultaneously enhances an Nrf2-mediated antioxidant response ...
Lei, Wang, Katayoon B, Ebrahimi, Michelle, Chyn, Marisol, Cano, James T, Handa   +4 more
openaire   +2 more sources

Autophagy upregulation ameliorates cell injury in Sequestosome 1 knockout podocytes in vitro

Biochemical and Biophysical Research Communications, 2017
Autophagy is a catabolic process to maintain intracellular homeostasis that degrades damaged proteins and organelles in mammalian cells. Podocytes are crucial for maintaining the normal function of the glomerular filtration barrier. In the present study, we aimed to investigate the high glucose-induced cell injury in human podocytes and the protective ...
Zhaoping, Li, Yuan, Yuan, Yan, Meng, Ying, Rong, Hao, Bai, Liyong, Chen   +5 more
openaire   +2 more sources

Sequestosome 1 (SQSTM1) Mutations in Paget’s Disease of Bone from the United States

Calcified Tissue International, 2008
Paget's disease of bone (PDB) is a localized bone disease characterized by excessive bone resorption due to overactive osteoclasts. Seven genetic loci (PDB1-PDB7) have been reported for late-onset PDB. PDB3 is the only locus where a gene, sequestosome 1 (SQSTM1), has been identified.
Emily C, Rhodes, Teresa L, Johnson-Pais, Frederick R, Singer, Donna P, Ankerst, Jan M, Bruder, Julie, Wisdom, Dave S B, Hoon, Emerald, Lin, Henry G, Bone, Kenneth J, Simcic, Robin J, Leach   +10 more
openaire   +2 more sources

Sequestosome 1/p62: a multi-domain protein with multi-faceted functions

Frontiers in Biology, 2012
The Sequestosome 1/p62 protein has been implicated in the regulation of a multitude of cellular processes such as NF-κB signaling, NRF2-driven oxidative stress response, protein turnover through the ubiquitin-proteasome pathway and the autophagosome/lysosome pathway, apoptosis and cellular metabolism.
Xiaoyan Liu, Jozsef Gal, Haining Zhu
openaire   +1 more source

The identification of high-performing antibodies for Sequestosome-1 for use in Western blot, immunoprecipitation and immunofluorescence

F1000Research, 2023
Riham Ayoubi, Walaa Alshafie, Irina Shlaifer   +2 more
exaly