Results 121 to 130 of about 10,790 (159)

Subtype-Consistent Upregulation of Ferroptosis-Associated Pathways in Breast Cancer with Heterogeneous Prognostic Implications and Systemic Response to Cryoablation. [PDF]

open access: yesInt J Mol Sci
Boroń K   +15 more
europepmc   +1 more source

Tumor stage-dependent expression of autophagy proteins in adrenocortical carcinoma. [PDF]

open access: yesFront Endocrinol (Lausanne)
Oliveira SB   +7 more
europepmc   +1 more source

Sequestosome 1/p62 enhances chronic skin inflammation [PDF]

open access: yesJournal of Allergy and Clinical Immunology, 2021
The molecular control of inflammation and epidermal thickening in skin lesions of patients with atopic dermatitis (AD) is not known. Sequestosome 1/p62 is a multifunctional adapter protein implicated in the control of key regulators of cellular homeostasis, such as proinflammatory and mechanistic target of rapamycin signaling.We sought to determine ...
Supawadee Sukseree   +2 more
exaly   +3 more sources

The sequestosome 1 protein: therapeutic vulnerabilities in ovarian cancer

Clinical and Translational Oncology, 2023
Ovarian cancer (OC) is the most deadly tumor that may develop in a woman's reproductive system. It is also one of the most common causes of death among those who have been diagnosed with cancer in women. An adapter protein known as sequestosome 1(SQSTM1) or p62 is primarily responsible for the transportation, degradation, and destruction of a wide ...
Maryam Nurzadeh   +3 more
openaire   +2 more sources

The Presence of the Autophagic Markers LC3B and Sequestosome 1/p62 in the Hydatidiform Mole

International Journal of Gynecological Pathology, 2022
Autophagy is implicated in normal pregnancy and various pathologic pregnancy conditions. Its presence in hydatidiform moles (HM) is unknown. We immunohistochemically studied 36 HM for LC3B and p62 to precisely determine their expression in the decidua, endometrium, and villi. Nineteen nonmolar pregnancies were also studied.
Georgia, Karpathiou   +6 more
openaire   +2 more sources

Sequestosome 1/p62: across diseases

Biomarkers, 2012
Sequestosome 1/p62 is a signal modulator or adaptor protein involved in receptor-mediated signal transduction. Sequestosome 1/p62 is gaining attention as it is involved in several diseases including Parkinson disease, Alzheimer disease, liver and breast cancer, Paget's disease of bone, obesity and insulin resistance.
Thangiah, Geetha   +3 more
openaire   +2 more sources

p62/Sequestosome-1

Veterinary Pathology, 2014
Canine cutaneous mast cell tumors (MCT) are common, frequently malignant neoplasms that are currently graded histologically for provision of prognostic information. Continuing evidence of subsets of MCT within certain grades (with differing survival times) indicate the need for biomarkers that will facilitate better patient stratification and also ...
T, Rich   +5 more
openaire   +2 more sources

Emerging role of p62/sequestosome-1 in the pathogenesis of Alzheimer's disease

Progress in Neurobiology, 2012
The p62/sequestosome-1 is a multifunctional protein containing several protein-protein interaction domains. Through these interactions p62 is involved in the regulation of cellular signaling and protein trafficking, aggregation and degradation. p62 protein can bind through its UBA motif to ubiquitinated proteins and control their aggregation and ...
Antero, Salminen   +5 more
openaire   +2 more sources

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