Results 111 to 120 of about 29,999,176 (178)

Palmitic acid-triggered B7H3 palmitoylation promotes immune escape

Nature Communications
Colorectal cancer responds poorly to immune checkpoint blockade in most patients with microsatellite-stable (MSS) tumors, highlighting the need for alternative targets.
Zejun Rao, Changsheng Huang, Qi Wu, Mao Li, Anyi Liu, Tong Zhu, Wangshuo Yang, Lanlan Yin, Shengyu Zhu, Xiaowei She, Chengxin Yu, Lang Liu, Pengcheng Li, Yucong Bai, Dongjing Zhang, Tianci Xie, Xiang Liu, Lu Liu, Feng Xu, Guihua Wang, Junbo Hu, Xuelai Luo   +21 more
doaj   +1 more source

Microglia-specific knock-out of NF-κB/IKK2 increases the accumulation of misfolded α-synuclein through the inhibition of p62/sequestosome-1-dependent autophagy in the rotenone model of Parkinson's disease. [PDF]

Glia, 2023
Rocha SM, Kirkley KS, Chatterjee D, Aboellail TA, Smeyne RJ, Tjalkens RB.   +5 more
europepmc   +1 more source

Changes in cytokine and sequestosome-1 levels during twin pregnancy progression: Association with outcome

Cytokine
Twin pregnancies are associated with complications and adverse outcomes. The number of twin pregnancies has increased in the last decades, due to the use of assisted reproductive techniques and delayed childbearing. Analysis of changes that occur during twin pregnancy progression and their association with outcome will lead to improved clinical ...
Angela Silvano, Giovanni Sisti, Viola Seravalli, Noemi Strambi, Astrid Parenti, Amedeo Amedei, Steven S. Witkin, Mariarosaria Di Tommaso   +7 more
openaire   +2 more sources

Generation and Characterization of Novel Monoclonal Antibodies Targeting p62/sequestosome-1 Across Human Neurodegenerative Diseases. [PDF]

J Neuropathol Exp Neurol, 2020
Trejo-Lopez JA, Sorrentino ZA, Riffe CJ, Prokop S, Dickson DW, Yachnis AT, Giasson BI.   +6 more
europepmc   +1 more source

Sequestosome 1-P62 : a new promoter of melanoma progression.

, 2013
Melanoma is an extremely aggressive type of cancer, whose incidence continues to increase worldwide. Despite of new recently approved therapies, melanoma remains highly resistant to treatment and relapses are frequently seen in clinical practice. Thus, the identification of new mechanisms of melanoma progression and translation of this knowledge into ...
openaire   +1 more source

Sequestosome-1 (p62) expression reveals chaperone-assisted selective autophagy in immune-mediated necrotizing myopathies. [PDF]

Brain Pathol, 2020
Fischer N, Preuße C, Radke J, Pehl D, Allenbach Y, Schneider U, Feist E, von Casteleyn V, Hahn K, Ruck T, Meuth SG, Goebel HH, Graf R, Mammen A, Benveniste O, Stenzel W.   +15 more
europepmc   +1 more source

NIMA-related kinase 9-mediated phosphorylation of the microtubule-associated LC3B protein at Thr-50 suppresses selective autophagy of p62/sequestosome 1. [PDF]

J Biol Chem, 2020
Shrestha BK, Skytte Rasmussen M, Abudu YP, Bruun JA, Larsen KB, Alemu EA, Sjøttem E, Lamark T, Johansen T.   +8 more
europepmc   +1 more source

Glioblastoma stem cells resist cuproptosis with circadian variation of copper levels

The Journal of Clinical Investigation
Cuproptosis involves accumulation of intracellular copper that triggers mitochondrial lipoylated protein aggregation and destabilization of iron–sulfur cluster proteins, leading to cell death. Pharmacologic induction of cuproptosis has been proposed as a
Fanen Yuan, Xujia Wu, Huairui Yuan, Donghai Wang, Tengfei Huang, Po Zhang, Hailong Mi, Weichi Wu, Suchet Taori, Priscilla Chan, Kenji Miki, Maged T. Ghoche, Linjie Zhao, Kalil G. Abdullah, Steve A. Kay, Qiulian Wu, Jeremy N. Rich   +16 more
doaj   +1 more source

Sequestosome 1 (p62) mitigates hypoxia-induced cardiac dysfunction by stabilizing hypoxia-inducible factor 1α and nuclear factor erythroid 2-related factor 2. [PDF]

Cardiovasc Res
Ghosh R, Fatahian AN, Rouzbehani OMT, Hathaway MA, Mosleh T, Vinod V, Vowles S, Stephens SL, Chung SD, Cao ID, Jonnavithula A, Symons JD, Boudina S.   +12 more
europepmc   +1 more source