Results 91 to 100 of about 29,999,176 (178)

Organelle Crosstalk and Metabolic Reprogramming in Idiopathic Pulmonary Fibrosis: Mechanisms and Therapeutic Implications

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease of unknown cause, marked by excessive deposition of extracellular matrix (ECM) components such as collagen. This pathological accumulation results in progressive destruction of the lung architecture and ultimately leads to respiratory failure.
Yining Zhang, Ling Teng, Limin Gong, Yuandong Fu, Minyi Qian   +4 more
wiley   +1 more source

The selective autophagic degradation of avian metapneumovirus subgroup C M2-2 protein via SQSTM1 suppresses viral replication

Autophagy Reports
Avian metapneumovirus subgroup C (aMPV/C) is an emerging pathogen that causes acute respiratory infection in chickens and turkeys. Sequestosome 1 (SQSTM1), a selective autophagy receptor, regulates cellular activity or viral replication by recognizing ...
Lei Hou, Jinshuo Guo, Jianwei Zhou, Jue Liu   +3 more
doaj   +1 more source

YOD1/TRAF6 association balances p62-dependent IL-1 signaling to NF-κB

eLife, 2017
The ubiquitin ligase TRAF6 is a key regulator of canonical IκB kinase (IKK)/NF-κB signaling in response to interleukin-1 (IL-1) stimulation. Here, we identified the deubiquitinating enzyme YOD1 (OTUD2) as a novel interactor of TRAF6 in human cells.
Gisela Schimmack, Kenji Schorpp, Kerstin Kutzner, Torben Gehring, Jara Kerstin Brenke, Kamyar Hadian, Daniel Krappmann   +6 more
doaj   +1 more source

Aloperine Suppresses Cancer Progression by Interacting with VPS4A to Inhibit Autophagosome‐lysosome Fusion in NSCLC

Advanced Science
Aloperine (ALO), a quinolizidine‐type alkaloid isolated from a natural Chinese herb, has shown promising antitumor effects. Nevertheless, its common mechanism of action and specific target remain elusive.
Weina Guo, Haifeng Zhou, Jingbo Wang, Junjie Lu, Yalan Dong, Zhenyu Kang, Xiaoyuan Qiu, Xiaohu Ouyang, Qianyun Chen, Junyi Li, Xiang Cheng, Keye Du, Mingyue Li, Zhihao Lin, Min Jin, Lei Zhang, Alexey Sarapultsev, Kuangyu Shi, Fangfei Li, Ge Zhang, Kongming Wu, Yueguang Rong, Vigo Heissmeyer, Yue Liu, Yunlun Li, Kun Huang, Shanshan Luo, Desheng Hu   +27 more
doaj   +1 more source

Phosphorylated TDP-43 (pTDP-43) aggregates in the axial skeletal muscle of patients with sporadic and familial amyotrophic lateral sclerosis

Acta Neuropathologica Communications, 2018
Muscle atrophy with weakness is a core feature of amyotrophic lateral sclerosis (ALS) that has long been attributed to motor neuron loss alone. However, several studies in ALS patients, and more so in animal models, have challenged this assumption with ...
Matthew D. Cykowski, Suzanne Z. Powell, Joan W. Appel, Anithachristy S. Arumanayagam, Andreana L. Rivera, Stanley H. Appel   +5 more
doaj   +1 more source

Electroacupuncture pretreatment alleviated cerebral ischemia-reperfusion injury via suppressing autophagy in cerebral cortex tissue in rats

针刺研究, 2019
ObjectiveTo investigate the effect of electroacupuncture(EA)preconditioning on autophagy in cerebral cortex tissues of rats with cerebral ischemia-reperfusion injury(CIRI),so as to explore its mechanisms underlying improvement of CIRI.MethodsThirty-three
HUANG Ya-guang, YANG Song-bai, DU Li-peng, CAI San-jin, FENG Zhi-tao, MEI Zhi-gang   +5 more
doaj   +2 more sources

Aberrant aging-associated p62 autophagic cascade in biopsied olfactory neuronal cells from patients with psychosis

Schizophrenia
Sequestosome-1/p62, a key mediator in the clearance of damaged organelles and macromolecules during autophagy, serves as a marker of biological aging. We demonstrate elevated p62 in biopsied neuronal cells in patients with psychosis compared to healthy ...
Kun Yang, Koko Ishizuka, Toshifumi Tomoda, Akira Sawa   +3 more
doaj   +1 more source

Regulation of the autophagy-marker Sequestosome 1 in periodontal cells and tissues by biomechanical loading

Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie, 2019
Orthodontic treatment is based on the principle of force application to teeth and subsequently to the surrounding tissues and periodontal cells. Sequestosome 1 (SQSTM1) is a well-known marker for autophagy, which is an important cellular mechanism of adaptation to stress.
Memmert, S., Nogueira, A. V.B., Damanaki, A., Nokhbehsaim, M., Rath-Deschner, B., Götz, W., Gölz, L., Cirelli, J. A., Till, A., Jäger, A., Deschner, J.   +10 more
openaire   +4 more sources

Successful Conversion Surgery after Ceritinib Monotherapy in a Patient with Advanced Inflammatory Myofibroblastic Tumor Harboring SQSTM1-ALK fusion

Journal of Cancer Research and Practice
Inflammatory myofibroblastic tumor (IMT) is an intermediate malignant neoplasm, and approximately 50% of patients are anaplastic lymphoma kinase positive (ALK+). Given this unique trait, ALK tyrosine kinase inhibitors (TKIs), initially developed for ALK+
Qi-An Wang, Chao-Wei Lee, Ren-Chin Wu, Chiao-En Wu   +3 more
doaj   +1 more source

Common Neurodegeneration-Associated Proteins Are Physiologically Expressed by Human B Lymphocytes and Are Interconnected via the Inflammation/Autophagy-Related Proteins TRAF6 and SQSTM1

Frontiers in Immunology, 2019
There is circumstantial evidence that, under neurodegenerative conditions, peptides deriving from aggregated or misfolded specific proteins elicit adaptive immune responses.
Serge Nataf, Serge Nataf, Serge Nataf, Marine Guillen, Laurent Pays, Laurent Pays, Laurent Pays   +6 more
doaj   +1 more source