Results 71 to 80 of about 29,999,176 (178)

Functional and structural consequences of TBK1 missense variants in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

Neurobiology of Disease, 2022
Mutations in the Tank-binding kinase 1 (TBK1) gene were identified in 2015 in individuals with frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). They account for ∼3–4% of cases.
Yuval Gurfinkel, Nicole Polain, Krushna Sonar, Penelope Nice, Ricardo L. Mancera, Sarah Lyn Rea   +5 more
doaj   +1 more source

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source

Mutation of the Sequestosome 1 (p62) Gene Increases Osteoclastogenesis but Does Not Induce Paget Disease [PDF]

, 2007
Paget disease is the most exaggerated example of abnormal bone remodeling, with the primary cellular abnormality in the osteoclast. Mutations in the p62 (sequestosome 1) gene occur in one-third of patients with familial Paget disease and in a minority of
Hiruma, Yuko, Dempster, David W., Singer, Frederick R., Zhou, Hua, Reddy, Sakamuri V., Roodman, G. David, Kurihara, Noriyoshi, Gruber, Helen E., Subler, Mark A., Windle, Jolene J.   +9 more
core   +1 more source

Chemical mimetics of the N-degron pathway alleviate systemic inflammation by activating mitophagy and immunometabolic remodeling

Experimental and Molecular Medicine, 2023
Sepsis: chemical modulation of selective autophagy alleviates systemic inflammation Sepsis is a life-threatening condition that occurs when the body’s response to infection damages its own organs.
Prashanta Silwal, Young Jae Kim, Yoon Jee Lee, In Soo Kim, Sang Min Jeon, Taylor Roh, Jin Kyung Kim, Min Joung Lee, Jun Young Heo, Doo Sin Jo, Sang-Hee Lee, Dong-Hyung Cho, Jin Man Kim, Yong Tae Kwon, Eun-Kyeong Jo   +14 more
doaj   +1 more source

Biomarkers Correlating With the Development of Oral Squamous Cell Carcinoma From Leukoplakia

Oral Diseases, EarlyView.
ABSTRACT Background We assessed protein biomarkers expressed in oral leukoplakia (OL) that are associated with the risk of transformation into oral squamous cell carcinoma (OSCC). Methods Tissue sections of OL transforming into OSCC (leuko‐ca), the corresponding OSCC and OL that did not progress to OSCC (leuko‐nonca) were analyzed with global relative ...
Daniel Giglio, Divya Ganesh, Bishwa Prakash Bhattarai, Tine Merete Søland, Jonas Sundberg, Annika Thorsell, Jenny Öhman, Dipak Sapkota, Bengt Hasséus   +8 more
wiley   +1 more source

Sequestosome-1/p62 Is the Key Intracellular Target of Innate Defense Regulator Peptide [PDF]

Journal of Biological Chemistry, 2009
Innate defense regulator-1 (IDR-1) is a synthetic peptide with no antimicrobial activity that enhances microbial infection control while suppressing inflammation. Previously, the effects of IDR-1 were postulated to impact several regulatory pathways including mitogen-activated protein kinase (MAPK) p38 and CCAAT-enhancer-binding protein, but how this ...
Yu, Hong Bing, Kielczewska, Agnieszka, Rozek, Annett, Takenaka, Shunsuke, Li, Yuling, Thorson, Lisa, Hancock, Robert E. W., Guarna, M. Marta, North, John R., Foster, Leonard J., Donini, Oreola, Finlay, B. Brett   +11 more
openaire   +2 more sources

Recurrent Mutation of the Gene Encoding sequestosome 1 (SQSTM1/p62) in Paget Disease of Bone [PDF]

, 2002
Paget disease of bone (PDB) is a common disorder characterized by focal and disorganized increases of bone turnover. Genetic factors are important in the pathogenesis of PDB.
Brown, Jacques P., Morissette, Jean, Raymond, Vincent, Laurin, Nancy   +3 more
core   +1 more source

One day of environment‐induced heat stress causes injury to the murine kidney

Experimental Physiology, EarlyView.
Abstract Environment‐induced heat stress (EIHS) results from sustained body temperature elevation owing to prolonged exposure to heat and humidity. We hypothesized that EIHS would cause kidney injury and cellular dysfunction. To test this hypothesis, female C57 mice were exposed to EIHS (n = 14; 37.6°C, 42.0% relative humidity) or thermoneutral (TN ...
Melissa Roths, Alyona Michael, Zachary J. Schlader, Joshua T. Selsby   +3 more
wiley   +1 more source

Posttranslational Modifications of p62/SQSTM1 in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
Schematic illustration of p62 as a posttranslational modifications (PTMs)‐programmed integrator in homeostasis, pathogenesis, and therapeutic targeting. (Left) Homeostasis: In physiological states, p62, through various PTMs such as phosphorylation, ubiquitination, and acetylation, coordinates essential cellular functions.
Weikai Wang, Xin Jiang, Runing Qiu, Chandra Sugiarto Wijaya, Miaoqin Chen, Jin Wang, Liyuan Zhu, Hongchuan Jin, Lifeng Feng   +8 more
wiley   +1 more source

α‐Synuclein Promotes Atherosclerosis by Impairing Macrophage Autophagic Flux

Aging Cell, Volume 25, Issue 10, October 2026.
Extracellular α‐synuclein activates the FLOT1‐PI3K‐mTOR axis to block autophagosome‐lysosomal fusion and lipophagy, thereby promoting macrophage foaming and atherosclerosis. Knockdown of FLOT1 or inhibition of PI3K‐mTOR rescues these effects. The graphical abstract image was created with Figdraw.
Mengting Qin, Xuying Xiang, Xiaoqing Guo, Shengnan Wang, Jiaojiao Chen, Dailiang Jiang, Yuhang Feng, Jiangnan Yu, Ling Mao   +8 more
wiley   +1 more source