Results 81 to 90 of about 10,790 (159)

Human iPSC‐NSC‐Derived Extracellular Vesicles Can Alleviate Alzheimer's Disease‐Linked Impairments in Mitochondria, mTOR Signaling, Autophagy, and Hippocampal Neurogenesis

Aging Cell, Volume 25, Issue 6, June 2026.
Intranasal administration of extracellular vesicles derived from human‐induced pluripotent stem cell‐derived neural stem cells in 5xFAD mice results in reduced oxidative stress, increased expression of proteins and genes associated with mitochondrial biogenesis and electron transport chain function, decreased mTOR activation, enhanced autophagy and ...
Leelavathi N. Madhu, Sahithi Attaluri, Sanya Kotian, Raghavendra Upadhya, Yogish Somayaji, Shama Rao, Prashant Tarale, Shruthi V. Ganesh, Charles Huard, Maheedhar Kodali, Bing Shuai, Vidya V. Rao, Ashok K. Shetty   +12 more
wiley   +1 more source

Aloperine Suppresses Cancer Progression by Interacting with VPS4A to Inhibit Autophagosome‐lysosome Fusion in NSCLC

Advanced Science
Aloperine (ALO), a quinolizidine‐type alkaloid isolated from a natural Chinese herb, has shown promising antitumor effects. Nevertheless, its common mechanism of action and specific target remain elusive.
Weina Guo, Haifeng Zhou, Jingbo Wang, Junjie Lu, Yalan Dong, Zhenyu Kang, Xiaoyuan Qiu, Xiaohu Ouyang, Qianyun Chen, Junyi Li, Xiang Cheng, Keye Du, Mingyue Li, Zhihao Lin, Min Jin, Lei Zhang, Alexey Sarapultsev, Kuangyu Shi, Fangfei Li, Ge Zhang, Kongming Wu, Yueguang Rong, Vigo Heissmeyer, Yue Liu, Yunlun Li, Kun Huang, Shanshan Luo, Desheng Hu   +27 more
doaj   +1 more source

Generation and characterization of human-derived induced pluripotent stem cell line (IGIBi010-A) from a patient with neurodegenerative disease phenotype carrying mutation in SQSTM1/p62 gene

Stem Cell Research
SQSTM1 (Sequestosome 1) also known as p62, plays several important physiological roles in the cell. It regulates autophagy and mitochondrial homeostasis and can further lead to metabolic reprogramming.
Istaq Ahmad, Himanshi Kapoor, Achal Kumar Srivastava, Mohammed Faruq   +3 more
doaj   +1 more source

Aberrant aging-associated p62 autophagic cascade in biopsied olfactory neuronal cells from patients with psychosis

Schizophrenia
Sequestosome-1/p62, a key mediator in the clearance of damaged organelles and macromolecules during autophagy, serves as a marker of biological aging. We demonstrate elevated p62 in biopsied neuronal cells in patients with psychosis compared to healthy ...
Kun Yang, Koko Ishizuka, Toshifumi Tomoda, Akira Sawa   +3 more
doaj   +1 more source

Common Neurodegeneration-Associated Proteins Are Physiologically Expressed by Human B Lymphocytes and Are Interconnected via the Inflammation/Autophagy-Related Proteins TRAF6 and SQSTM1

Frontiers in Immunology, 2019
There is circumstantial evidence that, under neurodegenerative conditions, peptides deriving from aggregated or misfolded specific proteins elicit adaptive immune responses.
Serge Nataf, Serge Nataf, Serge Nataf, Marine Guillen, Laurent Pays, Laurent Pays, Laurent Pays   +6 more
doaj   +1 more source

Regulation of the autophagy-marker Sequestosome 1 in periodontal cells and tissues by biomechanical loading

Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie, 2019
Orthodontic treatment is based on the principle of force application to teeth and subsequently to the surrounding tissues and periodontal cells. Sequestosome 1 (SQSTM1) is a well-known marker for autophagy, which is an important cellular mechanism of adaptation to stress.
Memmert, S., Nogueira, A. V.B., Damanaki, A., Nokhbehsaim, M., Rath-Deschner, B., Götz, W., Gölz, L., Cirelli, J. A., Till, A., Jäger, A., Deschner, J.   +10 more
openaire   +4 more sources

Successful Conversion Surgery after Ceritinib Monotherapy in a Patient with Advanced Inflammatory Myofibroblastic Tumor Harboring SQSTM1-ALK fusion

Journal of Cancer Research and Practice
Inflammatory myofibroblastic tumor (IMT) is an intermediate malignant neoplasm, and approximately 50% of patients are anaplastic lymphoma kinase positive (ALK+). Given this unique trait, ALK tyrosine kinase inhibitors (TKIs), initially developed for ALK+
Qi-An Wang, Chao-Wei Lee, Ren-Chin Wu, Chiao-En Wu   +3 more
doaj   +1 more source

The multifaceted role of SQSTM1/p62 in disc degeneration: A master regulator of cellular stress responses

Biochemistry and Biophysics Reports
Intervertebral disc degeneration (IDD) is a key contributor to lumbar degenerative diseases and chronic low back pain. Accumulating evidence indicates that Sequestosome 1 (SQSTM1/p62), a multifunctional adaptor protein, plays a pivotal role in IDD ...
Yang Hou, Lei Liu, Tianyi Zhao, Yongfei Guo, Jiangang Shi   +4 more
doaj   +1 more source

MiR-646 inhibited cell proliferation and migration by targeting P62 in glioma

Cell Adhesion & Migration
MiR-646, a small non-coding RNA, poorly expressed in a variety of tumors. This study aimed to clarify the role of miR-646 and its underlying mechanisms in glioblastoma (GBM).
Fangyu Ye, Heng Zhang, Qianqian Chen, Yanping Gui, Geng Tian, Yuting Ye, Xin Chen, Haijuan Dong, Xiangshan Fan, Jun Chen, RuiYing Yuan, Li Zhao, Juping Yu   +12 more
doaj   +1 more source

The E3 Ubiquitin Ligase SCF Cyclin F Promotes Sequestosome-1/p62 Insolubility and Foci Formation and is Dysregulated in ALS and FTD Pathogenesis. [PDF]

Mol Neurobiol, 2023
Davidson JM, Wu SSL, Rayner SL, Cheng F, Duncan K, Russo C, Newbery M, Ding K, Scherer NM, Balez R, García-Redondo A, Rábano A, Rosa-Fernandes L, Ooi L, Williams KL, Morsch M, Blair IP, Di Ieva A, Yang S, Chung RS, Lee A.   +20 more
europepmc   +1 more source