Results 101 to 110 of about 29,999,176 (178)

Generation and characterization of human-derived induced pluripotent stem cell line (IGIBi010-A) from a patient with neurodegenerative disease phenotype carrying mutation in SQSTM1/p62 gene

Stem Cell Research
SQSTM1 (Sequestosome 1) also known as p62, plays several important physiological roles in the cell. It regulates autophagy and mitochondrial homeostasis and can further lead to metabolic reprogramming.
Istaq Ahmad, Himanshi Kapoor, Achal Kumar Srivastava, Mohammed Faruq   +3 more
doaj   +1 more source

The multifaceted role of SQSTM1/p62 in disc degeneration: A master regulator of cellular stress responses

Biochemistry and Biophysics Reports
Intervertebral disc degeneration (IDD) is a key contributor to lumbar degenerative diseases and chronic low back pain. Accumulating evidence indicates that Sequestosome 1 (SQSTM1/p62), a multifunctional adaptor protein, plays a pivotal role in IDD ...
Yang Hou, Lei Liu, Tianyi Zhao, Yongfei Guo, Jiangang Shi   +4 more
doaj   +1 more source

The E3 Ubiquitin Ligase SCF Cyclin F Promotes Sequestosome-1/p62 Insolubility and Foci Formation and is Dysregulated in ALS and FTD Pathogenesis. [PDF]

Mol Neurobiol, 2023
Davidson JM, Wu SSL, Rayner SL, Cheng F, Duncan K, Russo C, Newbery M, Ding K, Scherer NM, Balez R, García-Redondo A, Rábano A, Rosa-Fernandes L, Ooi L, Williams KL, Morsch M, Blair IP, Di Ieva A, Yang S, Chung RS, Lee A.   +20 more
europepmc   +1 more source

MiR-646 inhibited cell proliferation and migration by targeting P62 in glioma

Cell Adhesion & Migration
MiR-646, a small non-coding RNA, poorly expressed in a variety of tumors. This study aimed to clarify the role of miR-646 and its underlying mechanisms in glioblastoma (GBM).
Fangyu Ye, Heng Zhang, Qianqian Chen, Yanping Gui, Geng Tian, Yuting Ye, Xin Chen, Haijuan Dong, Xiangshan Fan, Jun Chen, RuiYing Yuan, Li Zhao, Juping Yu   +12 more
doaj   +1 more source

Immunoexpression of p62/SQSTM1/Sequestosome-1 in human primary and recurrent IDH1/2 wild-type glioblastoma: A pilot study. [PDF]

Oncol Lett, 2022
Ieni A, Pizzimenti C, Broggi G, Caltabiano R, Germanò A, Barbagallo GMV, Vigneri P, Giuffrè G, Tuccari G.   +8 more
europepmc   +1 more source

Sporadic hyperphosphatasia syndrome featuring periostitis and accelerated skeletal turnover without receptor activator of nuclear factor-κB, osteoprotegerin, or sequestosome-1 gene defects

, 2007
Context: A middle-aged woman with recent-onset painful swollen fingers and widespread periostitis, elevated serum alkaline phosphatase (ALP) activity and erythrocyte sedimentation rate, and accelerated skeletal turnover was found not to have mutations in
Simsek, Suat, Zhang, Xiafang, Bravenboer, Nathalie, Whyte, Michael P., Basoski, Natalja M., Mumm, Steven, Netelenbos, J. Coen   +6 more
core   +1 more source

Constitutive Activation of p62/Sequestosome-1-Mediated Proteaphagy Regulates Proteolysis and Impairs Cell Death in Bortezomib-Resistant Mantle Cell Lymphoma. [PDF]

Cancers (Basel), 2022
Quinet G, Xolalpa W, Reyes-Garau D, Profitós-Pelejà N, Azkargorta M, Ceccato L, Gonzalez-Santamarta M, Marsal M, Andilla J, Aillet F, Bosch F, Elortza F, Loza-Alvarez P, Sola B, Coux O, Matthiesen R, Roué G, Rodriguez MS.   +17 more
europepmc   +1 more source

Moxibustion improves cardiac function by up-regulating autophagy-related proteins of cardiomyocytes in rats with chronic heart failure

针刺研究, 2019
Objective To observe the effect of moxibustion on cardiac function and the expression of autophagy-related proteins microtubule-associated protein 1 light chain 3(LC3)and selective autophagy receptor signaling adaptor sequestosome 1(SQSTM1/p62)in rats ...
LIU Na-na, JIA Xue-zhao, WANG Jing, ZHU Guo-qi, LI Dan, LI Qing-ling, MA Qiang   +6 more
doaj   +2 more sources

Spermidine induces cytoprotective autophagy of female germline stem cells in vitro and ameliorates aging caused by oxidative stress through upregulated sequestosome-1/p62 expression. [PDF]

Cell Biosci, 2021
Yuan X, Tian GG, Pei X, Hu X, Wu J.
europepmc   +1 more source

Sequestosome 1-P62 : un nuevo promotor en la progresión del melanoma [PDF]

, 2013
Tesis inédita de la Universidad Complutense de Madrid, Facultad de Medicina, Departamento de Anatomía Patológica, leída el 20-06-2013Melanoma is an extremely aggressive type of cancer, whose incidence continues to increase worldwide.
Riveiro Meireles, Erica
core