Results 101 to 110 of about 10,790 (159)

Microglia-specific knock-out of NF-κB/IKK2 increases the accumulation of misfolded α-synuclein through the inhibition of p62/sequestosome-1-dependent autophagy in the rotenone model of Parkinson's disease. [PDF]

Glia, 2023
Rocha SM, Kirkley KS, Chatterjee D, Aboellail TA, Smeyne RJ, Tjalkens RB.   +5 more
europepmc   +1 more source

Autophagy deficiency protects against ocular hypertension and glaucoma

Autophagy Reports
Glaucoma encompasses a spectrum of disorders characterized by the chronic degeneration of retinal ganglion cell (RGC) axons and the progressive loss of RGCs, resulting in visual impairment.
Angela Dixon, Myoung Sup Shim, April Nettesheim, Aislyn Coyne, Chien-Chia Su, Haiyan Gong, Paloma B. Liton   +6 more
doaj   +1 more source

Generation and Characterization of Novel Monoclonal Antibodies Targeting p62/sequestosome-1 Across Human Neurodegenerative Diseases. [PDF]

J Neuropathol Exp Neurol, 2020
Trejo-Lopez JA, Sorrentino ZA, Riffe CJ, Prokop S, Dickson DW, Yachnis AT, Giasson BI.   +6 more
europepmc   +1 more source

ePoster

European Journal of Neurology, Volume 33, Issue S1, June 2026.
wiley   +1 more source

Sequestosome-1 (p62) expression reveals chaperone-assisted selective autophagy in immune-mediated necrotizing myopathies. [PDF]

Brain Pathol, 2020
Fischer N, Preuße C, Radke J, Pehl D, Allenbach Y, Schneider U, Feist E, von Casteleyn V, Hahn K, Ruck T, Meuth SG, Goebel HH, Graf R, Mammen A, Benveniste O, Stenzel W.   +15 more
europepmc   +1 more source

NIMA-related kinase 9-mediated phosphorylation of the microtubule-associated LC3B protein at Thr-50 suppresses selective autophagy of p62/sequestosome 1. [PDF]

J Biol Chem, 2020
Shrestha BK, Skytte Rasmussen M, Abudu YP, Bruun JA, Larsen KB, Alemu EA, Sjøttem E, Lamark T, Johansen T.   +8 more
europepmc   +1 more source

Coxiella burnetii Subverts p62/Sequestosome 1 and Activates Nrf2 Signaling in Human Macrophages. [PDF]

Infect Immun, 2018
Winchell CG, Dragan AL, Brann KR, Onyilagha FI, Kurten RC, Voth DE.   +5 more
europepmc   +1 more source

Sequestosome 1 (p62) mitigates hypoxia-induced cardiac dysfunction by stabilizing hypoxia-inducible factor 1α and nuclear factor erythroid 2-related factor 2. [PDF]

Cardiovasc Res
Ghosh R, Fatahian AN, Rouzbehani OMT, Hathaway MA, Mosleh T, Vinod V, Vowles S, Stephens SL, Chung SD, Cao ID, Jonnavithula A, Symons JD, Boudina S.   +12 more
europepmc   +1 more source

SQSTM1/p62 (sequestosome 1) senses cellular ubiquitin stress through E2-mediated ubiquitination. [PDF]

Autophagy, 2018
Yang J, Peng H, Xu Y, Xie X, Hu R.
europepmc   +1 more source

p62/sequestosome 1 deficiency accelerates osteoclastogenesis in vitro and leads to Paget's disease-like bone phenotypes in mice. [PDF]

J Biol Chem, 2018
Zach F, Polzer F, Mueller A, Gessner A.
europepmc   +1 more source