Results 41 to 50 of about 29,999,176 (178)

Sequestosome 1/p62 Protein Is Associated with Autophagic Removal of Excess Hepatic Endoplasmic Reticulum in Mice* [PDF]

Journal of Biological Chemistry, 2016
Jia Fan, Kurt Zatloukal, Leopold F Fröhlich   +2 more
exaly   +2 more sources

The versatile defender: exploring the multifaceted role of p62 in intracellular bacterial infection

Frontiers in Cellular and Infection Microbiology, 2023
As a highly conserved, multifunctional protein with multiple domains, p62/SQSTM1 plays a crucial role in several essential cellular activities, particularly selective autophagy.
Yuhao Zhou, Yuhao Zhou, Shucheng Hua, Shucheng Hua, Lei Song, Lei Song   +5 more
doaj   +1 more source

p62/SQSTM1 droplets initiate autophagosome biogenesis and oxidative stress control

Molecular & Cellular Oncology, 2021
Selective autophagy contributes to the degradation of condensates, such as sequestosome 1-bodies, also called p62/SQSTM1-bodies. We showed that endogenous p62 forms gel-like structures, which serve as platforms for autophagosome formation and nuclear ...
Eeva-Liisa Eskelinen, Shun Kageyama, Masaaki Komatsu   +2 more
doaj   +1 more source

The role of autophagy related signal transduction pathways in bone metabolism [PDF]

Yixue xinzhi zazhi, 2022
Autophagy is an effective protective mechanism against tissue degeneration and plays an important role in cell proliferation, differentiation and maturation.
Zhi-Zhuo LI, Li-Jun SHI, Fu-Qiang GAO, Wei SUN   +3 more
doaj   +1 more source

Accumulation of Ubiquitin and Sequestosome-1 Implicate Protein Damage in Diacetyl-Induced Cytotoxicity. [PDF]

Am J Pathol, 2016
Inhaled diacetyl vapors are associated with flavorings-related lung disease, a potentially fatal airway disease. The reactive α-dicarbonyl group in diacetyl causes protein damage in vitro. Dicarbonyl/l-xylulose reductase (DCXR) metabolizes diacetyl into acetoin, which lacks this α-dicarbonyl group.
Hubbs AF, Fluharty KL, Edwards RJ, Barnabei JL, Grantham JT, Palmer SM, Kelly F, Sargent LM, Reynolds SH, Mercer RR, Goravanahally MP, Kashon ML, Honaker JC, Jackson MC, Cumpston AM, Goldsmith WT, McKinney W, Fedan JS, Battelli LA, Munro T, Bucklew-Moyers W, McKinstry K, Schwegler-Berry D, Friend S, Knepp AK, Smith SL, Sriram K.   +26 more
europepmc   +4 more sources

Protocol for stage 2 of the GaP study (genetic testing acceptability for Paget's disease of the bone) : a questionnaire study to investigate whether relatives of people with Paget's disease would accept genetic testing and preventative treatment if they were available [PDF]

, 2008
Background: Paget's disease of bone (PDB) disrupts normal bone architecture and causes pain, deformity, deafness, osteoarthritis, and fractures. Genetic factors play a role in PDB and genetic tests are now conducted for research purposes.
Ralston, Stuart H., Charnock Keith, Campbell, MK, Graeme MacLennan, John Weinman, McCallum Marilyn, Robertson, C., Weinman, John, Miedzybrodska Zosia, Langston Anne L, Weinman John, Vikki A Entwistle, Campbell, Marion K, McCallum, M., Robertson Clare, Entwistle, V.A, Campbell, Marion K., Francis, J., Charnock, K., Ralston, Stuart H, Langston, A. L., Robertson, Clare, MacLennan, Graeme Stewart, Entwistle Vikki A, Campbell, M K, Langston, AL, Francis, Jillian Joy, Marteau Theresa, Zosia Miedzybrodska, Miedzybrodska, Z, Langston, Anne L, Entwistle, Vikki A., Marilyn McCallum, Langston, A L, Entwistle, Vikki, Ralston, SH, Campbell, Marion Kay, Anne L Langston, Jill Francis, Ralston, S H, Miedzybrodzka, Zosia, Marie Johnston, Charnock, Keith, Francis, Jill, Weinman, J, Ralston, S.H, Weinman, J., Langston, A.L, Robertson, C, Entwistle, V A, Clare Robertson, McCallum, Marilyn, Ralston, S., Johnston Marie, Marteau, T, Campbell Marion K, Miedzybrodzka, Z., Entwistle, Vikki A, Campbell, M.K, Theresa Marteau, Johnston, M, Stuart H Ralston, Langston, Anne L., Entwistle, V., Johnston, M., Francis Jill, Ralston Stuart H, MacLennan, G, Campbell, M. K., Marteau, T., Entwistle, VA, Johnston, Marie, Marion K Campbell, Maclennan, Graeme, Miedzybrodska, Zosia, McCallum, M, MacLennan Graeme, Keith Charnock, Francis, J, Charnock, K, Marteau, Theresa, MacLennan, G.   +81 more
core   +2 more sources

Functional interaction between Sequestosome-1/p62 and Autophagy-Linked FYVE-containing protein WDFY3 in human osteoclasts [PDF]

, 2010
Peer ...
Hocking, Lynne J., Rogers, Michael J., Paul S. McCabe, Miep H. Helfrich, David J. Mellis, Mellis, David J., Lynne J. Hocking, Michael J. Rogers, Helfrich, Miep H., McCabe, Paul S.   +9 more
core   +1 more source

Bcl-2-dependent upregulation of autophagy by sequestosome 1/p62 in vitro. [PDF]

Acta Pharmacol Sin, 2013
To investigate whether sequestosome 1/p62 (p62), a key cargo adaptor protein involved in both the ubiquitin-proteasome system and the autophagy-lysosome system, could directly regulate autophagy in vitro.HEK 293 cells or HeLa cells were transfected with p62-expressing plasmids or siRNA targeting p62.
Zhou L, Wang HF, Ren HG, Chen D, Gao F, Hu QS, Fu C, Xu RJ, Ying Z, Wang GH.   +9 more
europepmc   +4 more sources

Chemotherapeutic sensitization of leptomycin B resistant lung cancer cells by pretreatment with doxorubicin. [PDF]

PLoS ONE, 2012
The development of novel targeted therapies has become an important research focus for lung cancer treatment. Our previous study has shown leptomycin B (LMB) significantly inhibited proliferation of lung cancer cells; however, p53 wild type lung cancer ...
Chuanwen Lu, Changxia Shao, Everardo Cobos, Kamaleshwar P Singh, Weimin Gao   +4 more
doaj   +1 more source

Essential Role of Sequestosome 1/p62 in Regulating Accumulation of Lys63-ubiquitinated Proteins [PDF]

Journal of Biological Chemistry, 2008
Sequestosome 1 (SQSTM1)/p62 is an interacting partner of the atypical protein kinase C zeta/iota and serves as a scaffold for cell signaling and ubiquitin binding, which is critical for several cell functions in vivo such as osteoclastogenesis, adipogenesis, and T cell activation.
Marie W, Wooten, Thangiah, Geetha, J Ramesh, Babu, M Lamar, Seibenhener, Junmin, Peng, Nancy, Cox, Maria-T, Diaz-Meco, Jorge, Moscat   +7 more
openaire   +2 more sources