Results 41 to 50 of about 10,790 (159)

NSUN2-Mediated M5c Dysregulation Promotes OSCC Ferroptosis

International Dental Journal
Aim or purpose: This study aimed to investigate the role of NSUN2-mediated 5-methylcytosine (m5C) methylation in regulating ferroptosis resistance and tumor progression in oral squamous cell carcinoma (OSCC), identifying potential epitranscriptomic ...
Yunyang Lu, Wei Zhao, Fangyang Shi, Jie Wu, Hui Gao, Hui Zhang, Jiajun Hu, Shiyu Lv, Weidong Du, Runze Li   +9 more
doaj   +1 more source

p62/Sequestosome 1 levels increase and phosphorylation is altered in Cx50D47A lenses, but deletion of p62/sequestosome 1 does not improve transparency.

Molecular vision, 2021
p62/Sequestosome 1 (p62) is a stress-induced protein that is involved in several different intracellular pathways, including regulation of aspects of protein degradation. p62 levels are elevated in several types of cataracts. We investigated whether levels of p62 and its phosphorylation were altered in the lenses of Cx50D47A mice, which express a ...
Oscar, Jara, Hubert, Mysliwiec, Peter J, Minogue, Viviana M, Berthoud, Eric C, Beyer   +4 more
openaire   +1 more source

“Membrane‐Guided” Repair Strategy: Precision Delivery of GGT1 Degrader for Targeted Repair and Regeneration of Spinal Cord Neurons

Advanced Science, EarlyView.
This study confirms that GGT1 is a key driver of neuronal ferroptosis following spinal cord injury. We developed NSCm@EA, a biomimetic delivery system coated with neural stem cell membranes, for precise delivery of enocyanin to injured neurons. By combining targeted delivery with ubiquitination degradation mechanisms, this system promotes MGRN1 ...
Tao Yang, Lei Ye, Peigen Xie, Tao Song, Jian Chen, Heng Zhao, Zhengshan Liu, Xi Chen, Jianing Ding, Xintian Ding, Ao Shao, Miaomiao Wu, Fengdong Zhao, Siyue Tao, Tao You   +14 more
wiley   +1 more source

Microplastics‐Induced Gut Microbiota Dysbiosis Accelerates Alzheimer's‐Like Pathology and Cognitive Decline via the Gut–Brain Axis

Advanced Science, EarlyView.
Microplastics (MPs) breach the gut‐brain axis by triggering taurine‐depleting microbiota dysbiosis that accelerates Alzheimer‐like pathology in 5XFAD mice. Taurine supplementation normalizes autophagy, microglial quiescence, and cognition, and plasma taurine inversely tracks cognitive decline in ADNI participants, revealing a readily translatable ...
Zifeng Wu, Jiarong Yang, Miaoxuan Zhang, Yi Li, Zhuling Tu, Ji Wang, Jin‐Tai Yu, Kun Guo, Rongcan Luo   +8 more
wiley   +1 more source

Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1. [PDF]

FEBS J, 2014
Autophagy is a homeostatic process that is important for degrading protein aggregates, nutrient deposits, dysfunctional organelles and several signaling molecules. p62/sequestosome‐1 is a protein that binds to several autophagy substrates, such as ubiquitinated proteins, damaged mitochondria and signaling molecules such as an Nrf2 inhibitor Keap1 ...
Ro SH, Semple IA, Park H, Park H, Park HW, Kim M, Kim JS, Lee JH.   +7 more
europepmc   +5 more sources

METTL14 Ameliorates Mitochondrial Dysfunction and Autophagy in Lens Epithelial Cells of Diabetic Cataracts via m6A Modification of RPL3

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Diabetic cataracts are a leading cause of blindness, with lens epithelial cells (LECs) exhibiting mitochondrial dysfunction and autophagy inhibition under high glucose (HG) conditions. Methyltransferase‐like 14 (METTL14), an RNA methyltransferase, regulates N6‐methyladenosine (m6A) RNA modification; however, its role in modulating ...
Rui Li, Xue Wang, Wei Du, Qian Li, Hong‐Ping Cui   +4 more
wiley   +1 more source

A role for sequestosome 1/p62 in mitochondrial dynamics, import and genome integrity

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2013
As a signaling scaffold, p62/sequestosome (p62/SQSTM1) plays important roles in cell signaling and degradation of misfolded proteins. While localization of p62 to mitochondria has been reported, a description of its function once there, remains unclear.
Seibenhener, M. Lamar, Du, Yifeng, Diaz-Meco, Maria-Theresa, Moscat, Jorge, Wooten, Michael C., Wooten, Marie W.   +5 more
openaire   +2 more sources

SQSTM1/p62 interacts with FKBP38 and regulates cell cycle in Cashmere goat foetal fibroblasts

Journal of Applied Animal Research, 2018
SQSTM1 (sequestosome 1, also known as p62) is a multifunctional scaffold protein implicated in diverse cell physiology processes, such as autophagy, cell signalling, and protein turnover.
Qiburi He, Yanfeng Wang, Keyu Zhao, Uyanga Binderiya, Lili Bao, Pingping Zhao, Dandan Yan, Huifang Hao, Xudong Guo, Zhigang Wang   +9 more
doaj   +1 more source

CUL5–ASB6 Complex Promotes p62/SQSTM1 Ubiquitination and Degradation to Regulate Cell Proliferation and Autophagy

Frontiers in Cell and Developmental Biology, 2021
p62/SQSTM1 (sequestosome-1) is a key protein involved in multiple cellular bioprocesses including autophagy, nutrient sensing, cell growth, cell death, and survival. Therefore, it is implicated in human diseases such as obesity and cancer.
Liyan Gong, Liyan Gong, Kaihua Wang, Kaihua Wang, Mengcheng Wang, Mengcheng Wang, Ronggui Hu, Ronggui Hu, Huaguang Li, Daming Gao, Daming Gao, Moubin Lin, Moubin Lin   +12 more
doaj   +1 more source

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source