Results 31 to 40 of about 10,790 (159)

p62/SQSTM1 droplets initiate autophagosome biogenesis and oxidative stress control

Molecular & Cellular Oncology, 2021
Selective autophagy contributes to the degradation of condensates, such as sequestosome 1-bodies, also called p62/SQSTM1-bodies. We showed that endogenous p62 forms gel-like structures, which serve as platforms for autophagosome formation and nuclear ...
Eeva-Liisa Eskelinen, Shun Kageyama, Masaaki Komatsu   +2 more
doaj   +1 more source

The role of autophagy related signal transduction pathways in bone metabolism [PDF]

Yixue xinzhi zazhi, 2022
Autophagy is an effective protective mechanism against tissue degeneration and plays an important role in cell proliferation, differentiation and maturation.
Zhi-Zhuo LI, Li-Jun SHI, Fu-Qiang GAO, Wei SUN   +3 more
doaj   +1 more source

Bcl-2-dependent upregulation of autophagy by sequestosome 1/p62 in vitro. [PDF]

Acta Pharmacol Sin, 2013
To investigate whether sequestosome 1/p62 (p62), a key cargo adaptor protein involved in both the ubiquitin-proteasome system and the autophagy-lysosome system, could directly regulate autophagy in vitro.HEK 293 cells or HeLa cells were transfected with p62-expressing plasmids or siRNA targeting p62.
Zhou L, Wang HF, Ren HG, Chen D, Gao F, Hu QS, Fu C, Xu RJ, Ying Z, Wang GH.   +9 more
europepmc   +4 more sources

Accumulation of Ubiquitin and Sequestosome-1 Implicate Protein Damage in Diacetyl-Induced Cytotoxicity. [PDF]

Am J Pathol, 2016
Inhaled diacetyl vapors are associated with flavorings-related lung disease, a potentially fatal airway disease. The reactive α-dicarbonyl group in diacetyl causes protein damage in vitro. Dicarbonyl/l-xylulose reductase (DCXR) metabolizes diacetyl into acetoin, which lacks this α-dicarbonyl group.
Hubbs AF, Fluharty KL, Edwards RJ, Barnabei JL, Grantham JT, Palmer SM, Kelly F, Sargent LM, Reynolds SH, Mercer RR, Goravanahally MP, Kashon ML, Honaker JC, Jackson MC, Cumpston AM, Goldsmith WT, McKinney W, Fedan JS, Battelli LA, Munro T, Bucklew-Moyers W, McKinstry K, Schwegler-Berry D, Friend S, Knepp AK, Smith SL, Sriram K.   +26 more
europepmc   +4 more sources

Chemotherapeutic sensitization of leptomycin B resistant lung cancer cells by pretreatment with doxorubicin. [PDF]

PLoS ONE, 2012
The development of novel targeted therapies has become an important research focus for lung cancer treatment. Our previous study has shown leptomycin B (LMB) significantly inhibited proliferation of lung cancer cells; however, p53 wild type lung cancer ...
Chuanwen Lu, Changxia Shao, Everardo Cobos, Kamaleshwar P Singh, Weimin Gao   +4 more
doaj   +1 more source

Clinical and Cellular Phenotypes Associated With Sequestosome 1 (SQSTM1) Mutations [PDF]

Journal of Bone and Mineral Research, 2006
Abstract Familial Paget's disease of bone has been shown to be associated with mutations in the ubiquitin-associated (UBA) domain of the sequestosome 1 (SQSTM1) gene. We have clinical findings on five families with diverse racial and ethnic backgrounds who all harbor SQSTM1 UBA domain mutations (P387L, P392L, D391fsX394, P392fsX394 ...
Robin J, Leach, Frederick R, Singer, Yasmin, Ench, Julie H, Wisdom, Diana S, Pina, Teresa L, Johnson-Pais   +5 more
openaire   +2 more sources

p62/Sequestosome-1 Associates with and Sustains the Expression of Retroviral Restriction Factor TRIM5α [PDF]

Journal of Virology, 2010
ABSTRACT TRIM5 proteins mediate a potent block to the cross-species transmission of retroviruses, the most well known being the TRIM5α protein from rhesus macaques, which potently inhibits human immunodeficiency virus type 1 (HIV-1) infection. This restriction occurs at an early stage in the replication cycle and is mediated by the binding of
O'Connor Christopher, Pertel Thomas, Gray Seth, Robia Seth L, Bakowska Joanna C, Luban Jeremy, Campbell Edward M   +6 more
openaire   +4 more sources

Effect of colony‐stimulating factor‐1 receptor overexpression on the growth of nasopharyngeal carcinoma xenografts in nude mice and its mechanism of action

Precision Radiation Oncology, 2020
Objectives Although nasopharyngeal carcinoma (NPC) is sensitive to radiotherapy, local recurrence and distant metastasis still occur in a proportion of patients due to radioresistance.
Zenan Chen, Yanrong Hao
doaj   +1 more source

Tumorigenesis in tuberous sclerosis complex is autophagy and p62/sequestosome 1 (SQSTM1)-dependent [PDF]

Proceedings of the National Academy of Sciences, 2011
Tuberous sclerosis complex (TSC) is a tumor suppressor syndrome characterized by benign tumors in multiple organs, including the brain and kidney. TSC-associated tumors exhibit hyperactivation of mammalian target of rapamycin complex 1 (mTORC1), a direct inhibitor of autophagy. Autophagy can either promote or inhibit tumorigenesis,
Andrey, Parkhitko, Faina, Myachina, Tasha A, Morrison, Khadijah M, Hindi, Neil, Auricchio, Magdalena, Karbowniczek, J Julia, Wu, Toren, Finkel, David J, Kwiatkowski, Jane J, Yu, Elizabeth Petri, Henske   +10 more
openaire   +2 more sources

The converging roles of sequestosome-1/p62 in the molecular pathways of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD)

Neurobiology of Disease, 2022
Investigations into the pathogenetic mechanisms underlying amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) have provided significant insight into the disease.
Jennilee M. Davidson, Roger S. Chung, Albert Lee   +2 more
doaj   +1 more source