Results 31 to 40 of about 29,999,176 (178)
Coxiella burnetii Subverts p62/Sequestosome 1 and Activates Nrf2 Signaling in Human Macrophages. [PDF]
Infect Immun, 2018 Coxiella burnetii is the causative agent of human Q fever, a debilitating flu-like illness that can progress to chronic disease presenting as endocarditis. Following inhalation, C.
Winchell CG +5 more
europepmc +2 more sources
Selective Autophagy Receptor p62/SQSTM1, a Pivotal Player in Stress and Aging
Frontiers in Cell and Developmental Biology, 2022 Efficient proteostasis is crucial for somatic maintenance, and its decline during aging leads to cellular dysfunction and disease. Selective autophagy is a form of autophagy mediated by receptors that target specific cargoes for degradation and is an ...
Anita V. Kumar +2 more
doaj +1 more source
p62 Overexpression Promotes Bone Metastasis of Lung Adenocarcinoma out of LC3-Dependent Autophagy
Frontiers in Oncology, 2021 p62 protein has been implicated in bone metastasis and is a multifunctional adaptor protein usually correlated with autophagy. Herein, we investigated p62 expression and its prognostic significance in bone metastasis of lung adenocarcinoma, and analyzed ...
Dongqi Li +6 more
doaj +1 more source
p62/sequestosome 1 regulates aggresome formation of pathogenic ataxin-3 with expanded polyglutamine. [PDF]
Int J Mol Sci, 2014 The cellular protein quality control system in association with aggresome formation contributes to protecting cells against aggregation-prone protein-induced toxicity. p62/Sequestosome 1 (p62) is a multifunctional protein which plays an important role in
Zhou L +5 more
europepmc +2 more sources
Scientific Reports, 2022 The aetiology of Amyotrophic Lateral Sclerosis (ALS) is still poorly understood. The discovery of genetic forms of ALS pointed out the mechanisms underlying this pathology, but also showed how complex these mechanisms are.
Giovanni De Marco +12 more
doaj +1 more source
Autophagy regulates rRNA synthesis
Nucleus, 2022 Autophagy has emerged as a key regulator of cell metabolism. Recently, we have demonstrated that autophagy is involved in RNA metabolism by regulating ribosomal RNA (rRNA) synthesis.
Yinfeng Xu, Wei Wan
doaj +1 more source
A quest for clarity in bone erosion: The role of sequestosome 1 in Paget's disease of bone. [PDF]
J Biol Chem, 2018 Alterations in the SQSTM1 gene are a putative cause of Paget's disease of bone, yet results are conflicting about how these mutations impact osteoclasts, the cell type believed to be the main pathological contributor. In this issue of JBC, Zach et al.
Michalski MN, Williams BO.
europepmc +4 more sources
Antibody Characterization Report for Sequestosome-1
, 2021 A peer-reviewed antibody characterization article corresponding to this Zenodo preprint is openly available at F1000Research: https://doi.org/10.12688/f1000research.132628.1 This report presents a guide to selecting high-quality commercial antibodies against Sequestosome-1 by immunoblot (Western blot), immunoprecipitation and immunofluorescence using ...
Ayoubi, Riham +5 more
openaire +2 more sources
Dataset for the Sequestosome-1 antibody screening study
, 2023 This project contains the following underlying data included in a study aiming at characterizing antibodies for the Sequestosome-1 protein. The study is available on Zenodo (https://doi.org/10.5281/zenodo.4818440)
Laflamme, Carl
core +1 more source
Nonhistone Lysine Methylation as a Protein Degradation Signal
Journal of Chemistry, 2022 Protein degradation is a fundamental feature of cellular life, and malfunction of this process is implicated in human disease. Ubiquitin tagging is the best characterized mechanism of targeting a protein for degradation; however, there are a growing ...
Nicholas A. Lehning, Brad E. Morrison
doaj +1 more source