Results 21 to 30 of about 10,790 (159)
Selective Autophagy Receptor p62/SQSTM1, a Pivotal Player in Stress and Aging
Frontiers in Cell and Developmental Biology, 2022 Efficient proteostasis is crucial for somatic maintenance, and its decline during aging leads to cellular dysfunction and disease. Selective autophagy is a form of autophagy mediated by receptors that target specific cargoes for degradation and is an ...
Anita V. Kumar +2 more
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p62 Overexpression Promotes Bone Metastasis of Lung Adenocarcinoma out of LC3-Dependent Autophagy
Frontiers in Oncology, 2021 p62 protein has been implicated in bone metastasis and is a multifunctional adaptor protein usually correlated with autophagy. Herein, we investigated p62 expression and its prognostic significance in bone metastasis of lung adenocarcinoma, and analyzed ...
Dongqi Li +6 more
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Scientific Reports, 2022 The aetiology of Amyotrophic Lateral Sclerosis (ALS) is still poorly understood. The discovery of genetic forms of ALS pointed out the mechanisms underlying this pathology, but also showed how complex these mechanisms are.
Giovanni De Marco +12 more
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Sequestosome 1/p62 – More than just a scaffold [PDF]
FEBS Letters, 2006 The interaction of proteins with ubiquitin receptors is key to solving the mystery that surrounds the functional role ubiquitin chains play in directing traffic. The specificity of these interactions is largely mediated by UbL/UBA domains. Sequestosome 1/p62 is a protein that is gaining attention as it is intimately involved in cell signaling, receptor
Seibenhener, M. Lamar +2 more
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Autophagy regulates rRNA synthesis
Nucleus, 2022 Autophagy has emerged as a key regulator of cell metabolism. Recently, we have demonstrated that autophagy is involved in RNA metabolism by regulating ribosomal RNA (rRNA) synthesis.
Yinfeng Xu, Wei Wan
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Antibody Characterization Report for Sequestosome-1
, 2021 A peer-reviewed antibody characterization article corresponding to this Zenodo preprint is openly available at F1000Research: https://doi.org/10.12688/f1000research.132628.1 This report presents a guide to selecting high-quality commercial antibodies against Sequestosome-1 by immunoblot (Western blot), immunoprecipitation and immunofluorescence using ...
Ayoubi, Riham +5 more
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A quest for clarity in bone erosion: The role of sequestosome 1 in Paget's disease of bone. [PDF]
J Biol Chem, 2018 Alterations in the SQSTM1 gene are a putative cause of Paget's disease of bone, yet results are conflicting about how these mutations impact osteoclasts, the cell type believed to be the main pathological contributor. In this issue of JBC, Zach et al.
Michalski MN, Williams BO.
europepmc +4 more sources
Sequestosome 1/p62 Protein Is Associated with Autophagic Removal of Excess Hepatic Endoplasmic Reticulum in Mice [PDF]
Journal of Biological Chemistry, 2016 Hua Yang, Hong-Min Ni, Ying-Hong Shi
exaly +2 more sources
Nonhistone Lysine Methylation as a Protein Degradation Signal
Journal of Chemistry, 2022 Protein degradation is a fundamental feature of cellular life, and malfunction of this process is implicated in human disease. Ubiquitin tagging is the best characterized mechanism of targeting a protein for degradation; however, there are a growing ...
Nicholas A. Lehning, Brad E. Morrison
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The versatile defender: exploring the multifaceted role of p62 in intracellular bacterial infection
Frontiers in Cellular and Infection Microbiology, 2023 As a highly conserved, multifunctional protein with multiple domains, p62/SQSTM1 plays a crucial role in several essential cellular activities, particularly selective autophagy.
Yuhao Zhou +5 more
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