Deficiency of p62/Sequestosome 1 causes hyperphagia due to leptin resistance in the brain. [PDF]
J Neurosci, 2013 The cytoplasmic regulatory protein p62 (Sequestosome 1/A170) is known to modulate various receptor-mediated intracellular signaling pathways.p62deficiency was shown to result in mature-onset obesity in mice, but the mechanisms underlying this abnormality remained unclear.
Harada H +15 more
europepmc +6 more sources
p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis [PDF]
Nature Communications, 2017 Soluble misfolded proteins that fail to be degraded by the ubiquitin proteasome system (UPS) are redirected to autophagy via specific adaptors, such as p62.
Hyunjoo Cha-Molstad +25 more
doaj +2 more sources
Enhanced Epithelial-to-Mesenchymal Transition Associated with Lysosome Dysfunction in Podocytes: Role of p62/Sequestosome 1 as a Signaling Hub [PDF]
Cellular Physiology and Biochemistry, 2015 Background: Autophagy is of importance in the regulation of cell differentiation and senescence in podocytes. It is possible that derangement of autophagy under different pathological conditions activates or enhances Epithelial-to-Mesenchymal Transition (
Guangbi Li +6 more
doaj +2 more sources
Domain-specific mutations in sequestosome 1 (SQSTM1) cause familial and sporadic Paget's disease [PDF]
Human Molecular Genetics, 2002 Paget's disease of bone (PDB) is a common disorder characterized by focal abnormalities of increased and disorganized bone turnover. Genetic factors are important in the pathogenesis of PDB, and in previous studies, we and others identified a locus for familial PDB by genome-wide search on 5q35-qter (PDB3). The gene encoding sequestosome 1 (SQSTM1/p62)
Hocking, Lynne J. +11 more
openaire +7 more sources
Sequestosome 1/p62: A multitasker in the regulation of malignant tumor aggression (Review). [PDF]
Int J Oncol, 2021 Sequestosome 1 (SQSTM1)/p62 is an adapter protein mainly involved in the transportation, degradation and destruction of various proteins that cooperates with components of autophagy and the ubiquitin‑proteasome degradation pathway. Numerous studies have shown that SQSTM1/p62 functions at multiple levels, including involvement in genetic stability or ...
Tang J +6 more
europepmc +4 more sources
p62/sequestosome-1 knockout delays neurodegeneration induced by Drp1 loss. [PDF]
Neurochem Int, 2018 Purkinje neurons, one of the largest neurons in the brain, are critical for controlling body movements, and the dysfunction and degeneration of these cells cause ataxia. Purkinje neurons require a very efficient energy supply from mitochondria because of their large size and extensive dendritic arbors.
Yamada T +4 more
europepmc +4 more sources
A proximity-dependent biotinylation (BioID) approach flags the p62/sequestosome-1 protein as a caspase-1 substrate. [PDF]
J Biol Chem, 2018 International audienceThe inflammasome is a major component of the innate immune system, and its main function is to activate caspase-1, a cysteine protease that promotes inflammation by inducing interleukin-1β (IL-1β) maturation and release into the ...
Jamilloux Y +7 more
europepmc +2 more sources
HPV16 Induces Formation of Virus-p62-PML Hybrid Bodies to Enable Infection
Viruses, 2022 Human papillomaviruses (HPVs) inflict a significant burden on the human population. The clinical manifestations caused by high-risk HPV types are cancers at anogenital sites, including cervical cancer, as well as head and neck cancers.
Linda Schweiger +7 more
doaj +1 more source
Cancer Reports, 2023 Background Inflammatory myofibroblastic tumor (IMT) is an ultra‐rare soft tissue neoplasm associated with fusion proteins encompassing the anaplastic lymphoma kinase (ALK) protein fused to a variety of partner proteins.
Cass G. G. Sunga +4 more
doaj +1 more source