Results 11 to 20 of about 10,790 (159)
Sequestosome 1 Is Part of the Interaction Network of VAPB [PDF]
International Journal of Molecular Sciences, 2021 VAPB (Vesicle-Associated-membrane Protein-associated protein B) is a tail-anchored membrane protein of the endoplasmic reticulum that can also be detected at the inner nuclear membrane. As a component of many contact sites between the endoplasmic reticulum and other organelles, VAPB is engaged in multiple protein interactions with a plethora of binding
Christina James +2 more
exaly +8 more sources
TRAF6-mediated ubiquitination of NEMO requires p62/sequestosome-1
Molecular Immunology, 2014 The atypical protein kinase C-interacting protein p62/sequestosome-1 (p62) has emerged as a crucial molecule in a variety of cellular functions due to its involvement in various signaling mechanisms. p62 has been implicated in the activation of NF-κB in TNFα-stimulated cells and has been shown to be activated in response to interleukin-1β (IL-1β). Here
Tiziana Zotti +2 more
exaly +6 more sources
Sequestosome 1/p62, a Scaffolding Protein, Is a Newly Identified Partner of IRS-1 Protein [PDF]
Journal of Biological Chemistry, 2012 Defects in the insulin-signaling pathway may lead to the development of skeletal muscle insulin resistance, which is one of the earliest abnormalities detected in individuals with the metabolic syndrome and predisposes them to develop type 2 diabetes. Previous studies have shown that deletion of the mouse sequestosome 1/p62 gene results in mature-onset
Thangiah Geetha +2 more
exaly +5 more sources
p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis [PDF]
Nature Communications, 2017 Soluble misfolded proteins that fail to be degraded by the ubiquitin proteasome system (UPS) are redirected to autophagy via specific adaptors, such as p62.
Hyunjoo Cha-Molstad +25 more
doaj +2 more sources
Enhanced Epithelial-to-Mesenchymal Transition Associated with Lysosome Dysfunction in Podocytes: Role of p62/Sequestosome 1 as a Signaling Hub [PDF]
Cellular Physiology and Biochemistry, 2015 Background: Autophagy is of importance in the regulation of cell differentiation and senescence in podocytes. It is possible that derangement of autophagy under different pathological conditions activates or enhances Epithelial-to-Mesenchymal Transition (
Guangbi Li +6 more
doaj +2 more sources
Sequestosome 1/p62: A multitasker in the regulation of malignant tumor aggression (Review). [PDF]
Int J Oncol, 2021 Sequestosome 1 (SQSTM1)/p62 is an adapter protein mainly involved in the transportation, degradation and destruction of various proteins that cooperates with components of autophagy and the ubiquitin‑proteasome degradation pathway. Numerous studies have shown that SQSTM1/p62 functions at multiple levels, including involvement in genetic stability or ...
Tang J +6 more
europepmc +4 more sources
p62/sequestosome-1 knockout delays neurodegeneration induced by Drp1 loss. [PDF]
Neurochem Int, 2018 Purkinje neurons, one of the largest neurons in the brain, are critical for controlling body movements, and the dysfunction and degeneration of these cells cause ataxia. Purkinje neurons require a very efficient energy supply from mitochondria because of their large size and extensive dendritic arbors.
Yamada T +4 more
europepmc +4 more sources
HPV16 Induces Formation of Virus-p62-PML Hybrid Bodies to Enable Infection
Viruses, 2022 Human papillomaviruses (HPVs) inflict a significant burden on the human population. The clinical manifestations caused by high-risk HPV types are cancers at anogenital sites, including cervical cancer, as well as head and neck cancers.
Linda Schweiger +7 more
doaj +1 more source
TAK1 converts Sequestosome 1/p62 from an autophagy receptor to a signaling platform. [PDF]
EMBO Rep, 2019 The protein p62/Sequestosome 1 (p62) has been described as a selective autophagy receptor and independently as a platform for pro-inflammatory and other intracellular signaling. How these seemingly disparate functional roles of p62 are coordinated has not been resolved.
Kehl SR +6 more
europepmc +5 more sources
Cancer Reports, 2023 Background Inflammatory myofibroblastic tumor (IMT) is an ultra‐rare soft tissue neoplasm associated with fusion proteins encompassing the anaplastic lymphoma kinase (ALK) protein fused to a variety of partner proteins.
Cass G. G. Sunga +4 more
doaj +1 more source