Results 11 to 20 of about 29,999,176 (178)
Sequestosome 1 Is Part of the Interaction Network of VAPB [PDF]
International Journal of Molecular Sciences, 2021 VAPB (Vesicle-Associated-membrane Protein-associated protein B) is a tail-anchored membrane protein of the endoplasmic reticulum that can also be detected at the inner nuclear membrane. As a component of many contact sites between the endoplasmic reticulum and other organelles, VAPB is engaged in multiple protein interactions with a plethora of binding
Christof Lenz +2 more
exaly +11 more sources
TRAF6-mediated ubiquitination of NEMO requires p62/sequestosome-1
Molecular Immunology, 2014 The atypical protein kinase C-interacting protein p62/sequestosome-1 (p62) has emerged as a crucial molecule in a variety of cellular functions due to its involvement in various signaling mechanisms. p62 has been implicated in the activation of NF-κB in TNFα-stimulated cells and has been shown to be activated in response to interleukin-1β (IL-1β). Here
Carla Reale +2 more
exaly +7 more sources
Sequestosome 1/p62 – More than just a scaffold [PDF]
FEBS Letters, 2006 The interaction of proteins with ubiquitin receptors is key to solving the mystery that surrounds the functional role ubiquitin chains play in directing traffic. The specificity of these interactions is largely mediated by UbL/UBA domains. Sequestosome 1/p62 is a protein that is gaining attention as it is intimately involved in cell signaling, receptor
Seibenhener, M. Lamar +2 more
openaire +4 more sources
TAK1 converts Sequestosome 1/p62 from an autophagy receptor to a signaling platform. [PDF]
EMBO Rep, 2019 The protein p62/Sequestosome 1 (p62) has been described as a selective autophagy receptor and independently as a platform for pro-inflammatory and other intracellular signaling. How these seemingly disparate functional roles of p62 are coordinated has not been resolved.
Kehl SR +6 more
europepmc +7 more sources
Sequestosome 1/p62, a Scaffolding Protein, Is a Newly Identified Partner of IRS-1 Protein* [PDF]
Journal of Biological Chemistry, 2012 Defects in the insulin-signaling pathway may lead to the development of skeletal muscle insulin resistance, which is one of the earliest abnormalities detected in individuals with the metabolic syndrome and predisposes them to develop type 2 diabetes. Previous studies have shown that deletion of the mouse sequestosome 1/p62 gene results in mature-onset
Thangiah Geetha +2 more
exaly +5 more sources
A role for sequestosome 1/p62 in mitochondrial dynamics, import and genome integrity [PDF]
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2013 As a signaling scaffold, p62/sequestosome (p62/SQSTM1) plays important roles in cell signaling and degradation of misfolded proteins. While localization of p62 to mitochondria has been reported, a description of its function once there, remains unclear.
Seibenhener, M. Lamar +5 more
openaire +3 more sources
Tumorigenesis in tuberous sclerosis complex is autophagy and p62/sequestosome 1 (SQSTM1)-dependent [PDF]
Proceedings of the National Academy of Sciences, 2011 Tuberous sclerosis complex (TSC) is a tumor suppressor syndrome characterized by benign tumors in multiple organs, including the brain and kidney. TSC-associated tumors exhibit hyperactivation of mammalian target of rapamycin complex 1 (mTORC1), a direct inhibitor of autophagy. Autophagy can either promote or inhibit tumorigenesis,
Andrey, Parkhitko +10 more
openaire +3 more sources
p62/Sequestosome-1 Associates with and Sustains the Expression of Retroviral Restriction Factor TRIM5α [PDF]
Journal of Virology, 2010 ABSTRACT TRIM5 proteins mediate a potent block to the cross-species transmission of retroviruses, the most well known being the TRIM5α protein from rhesus macaques, which potently inhibits human immunodeficiency virus type 1 (HIV-1) infection. This restriction occurs at an early stage in the replication cycle and is mediated by the binding of
O'Connor Christopher +6 more
openaire +5 more sources
Emerging role of p62/sequestosome-1 in the pathogenesis of Alzheimer's disease
Progress in Neurobiology, 2012 The p62/sequestosome-1 is a multifunctional protein containing several protein-protein interaction domains. Through these interactions p62 is involved in the regulation of cellular signaling and protein trafficking, aggregation and degradation. p62 protein can bind through its UBA motif to ubiquitinated proteins and control their aggregation and ...
Antero, Salminen +5 more
openaire +3 more sources
Veterinary Pathology, 2014 Canine cutaneous mast cell tumors (MCT) are common, frequently malignant neoplasms that are currently graded histologically for provision of prognostic information. Continuing evidence of subsets of MCT within certain grades (with differing survival times) indicate the need for biomarkers that will facilitate better patient stratification and also ...
T, Rich +5 more
openaire +3 more sources