Results 11 to 20 of about 19,143 (190)

Discovery and biochemical characterization of the D-aspartyl endopeptidase activity of the serine protease LACTB

Journal of Biological Chemistry
Non-enzymatic D-isomerization of aspartic acid in proteins has been observed in lesions associated with age-related diseases, including cataracts and Alzheimer's disease. Given that D-isomerization of Asp disrupts the physiological conformation of proteins, it has been postulated that D-isomerization of Asp in proteins is a key factor in the ...
Genta Ito, Naoko Utsunomiya‐Tate
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Roles of young serine-endopeptidase genes in survival and reproduction revealed rapid evolution of phenotypic effects at adult stages [PDF]

Fly, 2011
Our recent study found that 30% of young genes were essential for viability that determines development through stages from embryo to pupae in Drosophila melanogaster, revealing rapidly evolving genetic components involved in the evolution of development. Meanwhile, many young genes did not produce complete lethal phenotype upon constitutive knockdown,
Sidi Chen, Haiwang Yang, Benjamin H. Krinsky, Anthony Lin Zhang, Manyuan Long   +4 more
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A Cytosolic Serine Endopeptidase from Trypanosoma cruzi Is Required for the Generation of Ca2+ Signaling in Mammalian Cells [PDF]

The Journal of Cell Biology, 1997
An early event in the Trypanosoma cruzi cell invasion process, the recruitment of host lysosomes, led us to investigate the involvement of signal transduction. Infective trypomastigotes were found to contain a soluble Ca2+-signaling activity for mammalian cells that is sensitive to protease inhibitors.
Barbara A. Burleigh, Elisabet Caler, Paul Webster, Norma W. Andrews   +3 more
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Stage-specific transcriptomic analysis reveals insights into the development, reproduction and biological function of allergens in the European house dust mite Dermatophagoides pteronyssinus [PDF]

BMC Genomics
Background House dust mites (HDMs) such as Dermatophagoides pteronyssinus are major allergy elicitors worldwide, yet their gene expression across developmental stages remains underexplored.
José Cristian Vidal-Quist, Félix Ortego, Bart N. Lambrecht, Stephane Rombauts, Pedro Hernández-Crespo   +4 more
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Characterisation of proteins in excretory/secretory products collected from salmon lice, Lepeophtheirus salmonis [PDF]

Parasites & Vectors, 2018
Background The salmon louse, Lepeophtheirus salmonis, is an ectoparasitic copepod which feeds on the mucus, skin and blood of salmonid fish species. The parasite can persist on the surface of the fish without any effective control being exerted by the ...
Scott Hamilton, Kevin McLean, Sean J. Monaghan, Carol McNair, Neil F. Inglis, Hazel McDonald, Sandra Adams, Randolph Richards, William Roy, Patrick Smith, James Bron, Alasdair J. Nisbet, David Knox   +12 more
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Characterization of a prolyl endopeptidase from Flavobacterium meningosepticum. Complete sequence and localization of the active-site serine.

Journal of Biological Chemistry, 1992
A prolyl endopeptidase was purified from Flavobacterium meningosepticum. It was digested with trypsin. Two oligonucleotides, based on tryptic peptide sequences and used in PCR experiments, amplified a 300-base pair (bp) fragment. A 2.4-kilobase EcoRI fragment that hybridized to the 300-bp probe was cloned in lambda ZAP and sequenced from both strands ...
Sylvie Chevallier, Pierrette Goeltz, Pierre Thibault, Debra L. Banville, Jean Gagnon   +4 more
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Catalytic properties and polymorphism of serine endopeptidases from the midgut gland of the brown shrimp Crangon crangon (Decapoda, Caridea) [PDF]

Marine Biology, 2012
The brown shrimp Crangon crangon is a key species in the coastal areas of the North Sea. It constitutes a significant food source for fishes. Simultaneously, it is an important predator on a wide range of invertebrates. C. crangon shows a variety of digestive enzymes that allow to utilizing a wide range of food items.
Reinhard Saborowski, Jessica Schatte, Luis Giménez   +2 more
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Isolation and Characterization of a Highly Specific Serine Endopeptidase from an Oral Strain of Staphylococcus epidermidis

Biological Chemistry, 2001
Infection by Staphylococcus epidermidis, an opportunistic pathogen, has become a major problem due to the increased use of implanted medical devices and the growing number of patients who are therapeutically or infectiously immunosuppressed. These infections appear to proceed via modulation of the coagulation and complement systems.
J Moon, Agnieszka Banbula, Aneta Oleksy, John A. Mayo, James Travis   +4 more
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Tsetse fly (Glossina pallidipes) midgut responses to Trypanosoma brucei challenge [PDF]

Parasites & Vectors, 2017
Background Tsetse flies (Glossina spp.) are the prominent vector of African trypanosome parasites (Trypanosoma spp.) in sub-Saharan Africa, and Glossina pallidipes is the most widely distributed species in Kenya.
Rosemary Bateta, Jingwen Wang, Yineng Wu, Brian L. Weiss, Wesley C. Warren, Grace A. Murilla, Serap Aksoy, Paul O. Mireji   +7 more
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Subunit III of ruminant procarboxypeptidase A‐S6 complexes and pancreatic proteases E a new family of pancreatic serine endopeptidases?

FEBS Letters, 1988
Subunit III (BSIII) of the bovine ternary complex of procarboxypeptidase A‐S6 (PCPA‐S6), a defective serine endopeptidase‐like protein, actively synthesized by the pancreas of some ruminant species, is highly homologous to human protease E (HPE). Both proteins possess the same atypical disulfide bridge in position 98–99b.
Christian Cambillau, Brigitte Kerfélec, M. Sciaky, Catherine Chapus   +3 more
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