Results 21 to 30 of about 185,677 (239)

Macrocyclic Inhibitors of HGF-Activating Serine Proteases Overcome Resistance to Receptor Tyrosine Kinase Inhibitors and Block Lung Cancer Progression.

Journal of Medicinal Chemistry, 2021
Hepatocyte growth factor (HGF), the ligand for the MET receptor tyrosine kinase, is a tumor-promoting factor that is abundant in the tumor microenvironment. Proteolytic activation of inactive pro-HGF by one or more of the serine endopeptidases matriptase,
V. Damalanka, Jorine Voss, Matthew W. Mahoney, Tina M Primeau, Shunqiang Li, L. Klampfer, J. Janetka   +6 more
semanticscholar   +1 more source

Two avian Plasmodium species trigger different transcriptional responses on their vector Culex pipiens

Molecular Ecology, EarlyView., 2023
Abstract Malaria is a mosquito‐borne disease caused by protozoans of the genus Plasmodium that affects both humans and wildlife. The fitness consequences of infections by avian malaria are well known in birds, however, little information exists on its impact on mosquitoes.
Marta Garrigós, Guillem Ylla, Josué Martínez‐de la Puente, Jordi Figuerola, María José Ruiz‐López   +4 more
wiley   +1 more source

Alterations in gene expression of proprotein convertases in human lung cancer have a limited number of scenarios. [PDF]

PLoS ONE, 2013
Proprotein convertases (PCs) is a protein family which includes nine highly specific subtilisin-like serine endopeptidases in mammals. The system of PCs is involved in carcinogenesis and levels of PC mRNAs alter in cancer, which suggests expression ...
Ilya V Demidyuk, Andrey V Shubin, Eugene V Gasanov, Alexander M Kurinov, Vladimir V Demkin, Tatyana V Vinogradova, Marina V Zinovyeva, Alexander V Sass, Irina B Zborovskaya, Sergey V Kostrov   +9 more
doaj   +1 more source

Plant-Programmed Cell Death-Associated Genes Participation in Pinus sylvestris L. Trunk Tissue Formation

Plants, 2022
Molecular genetic markers of various PCD (programmed cell death) variants during xylo- and phloemogenesis have been identified for the first time in Scots pine under lingonberry pine forest conditions in Northwest Russia (middle taiga subzone).
Yulia L. Moshchenskaya, Natalia A. Galibina, Kseniya M. Nikerova, Tatiana V. Tarelkina, Maksim A. Korzhenevsky, Irina N. Sofronova, Maria A. Ershova, Ludmila I. Semenova   +7 more
doaj   +1 more source

Aminobenzosuberone Scaffold as a Modular Chemical Tool for the Inhibition of Therapeutically Relevant M1 Aminopeptidases

Molecules, 2018
The synthesis of racemic substituted 7-amino-5,7,8,9-tetrahydrobenzocyclohepten-6-one hydrochlorides was optimized to enhance reproducibility and increase the overall yield.
Emmanuel Salomon, Marjorie Schmitt, Anil Kumar Marapaka, Athanasios Stamogiannos, Germain Revelant, Céline Schmitt, Sarah Alavi, Isabelle Florent, Anthony Addlagatta, Efstratios Stratikos, Céline Tarnus, Sébastien Albrecht   +11 more
doaj   +1 more source

Filling the Gaps to Solve the Extensin Puzzle [PDF]

, 2018
Extensins (EXTs) are highly repetitive plant O-glycoproteins that require several post-translational modifications (PTMs) to become functional in plant cell walls.
Borassi, Cecilia, Bringas, Mauro, Capece, Luciana, Estevez, Jose Manuel, Marzol, Eliana, Rodríguez Garcia, Diana Rosa, Sede, Ana Rocío   +6 more
core   +1 more source

The midgut transcriptome of Aedes aegypti fed with saline or protein meals containing chikungunya virus reveals genes potentially involved in viral midgut escape

BMC Genomics, 2017
Background The mosquito Aedes aegypti is the primary vector for medically important arthropod-borne viruses, including chikungunya virus (CHIKV). Following oral acquisition, an arbovirus has to persistently infect several organs in the mosquito before ...
Shengzhang Dong, Susanta K. Behura, Alexander W. E. Franz   +2 more
doaj   +1 more source

Presence and expression of hydrogenase specific C-terminal endopeptidases in cyanobacteria [PDF]

, 2003
BACKGROUND: Hydrogenases catalyze the simplest of all chemical reactions: the reduction of protons to molecular hydrogen or vice versa. Cyanobacteria can express an uptake, a bidirectional or both NiFe-hydrogenases.
Batur, Mehtap, Lindblad, Peter, Wünschiers, Röbbe   +2 more
core   +3 more sources

MEPE-derived ASARM peptide inhibits odontogenic differentiation of dental pulp stem cells and impairs mineralization in tooth models of X-linked hypophosphatemia. [PDF]

PLoS ONE, 2013
Mutations in PHEX (phosphate-regulating gene with homologies to endopeptidases on the X-chromosome) cause X-linked familial hypophosphatemic rickets (XLH), a disorder having severe bone and tooth dentin mineralization defects.
Benjamin Salmon, Claire Bardet, Mayssam Khaddam, Jiar Naji, Benjamin R Coyac, Brigitte Baroukh, Franck Letourneur, Julie Lesieur, Franck Decup, Dominique Le Denmat, Antonino Nicoletti, Anne Poliard, Peter S Rowe, Eric Huet, Sibylle Opsahl Vital, Agnès Linglart, Marc D McKee, Catherine Chaussain   +17 more
doaj   +1 more source

Family C1 cysteine proteases: Biological diversity or redundancy? [PDF]

, 2003
Recent progress in the identification and partial characterization of novel genes encoding cysteine proteases of the papain family has considerably increased our knowledge of this family of enzymes.
Brömme D., Coulombe R., Musil D., Navab R., Tepel C.   +4 more
core   +1 more source