Results 1 to 10 of about 248,258 (248)

Arabidopsis Serine Decarboxylase 1 (SDC1) in Phospholipid and Amino Acid Metabolism

Frontiers in Plant Science, 2018
Arabidopsis thaliana serine decarboxylase 1 (SDC1) catalyzes conversion of serine to ethanolamine, the first reaction step of phosphatidylcholine and phosphatidylethanolamine biosynthesis.
Yu-chi Liu, Farrel Gunawan, Ian Sofian Yunus, Yuki Nakamura   +3 more
doaj   +1 more source

The “serine code” of metabolic reprogramming: multidimensional roles of the serine synthesis pathway in tumors and novel breakthroughs for targeted therapy

Frontiers in Immunology
As a pivotal contributor to tumor metabolism following glucose and glutamine, serine plays a crucial role in the metabolic network of tumors via its de novo synthesis pathway (SSP).
Peng Su, Peng Su, Ying Yang, Ying Yang, Hong Zheng   +4 more
doaj   +1 more source

Phosphoglycerate mutase regulates Treg differentiation through control of serine synthesis and one-carbon metabolism

eLife
The differentiation and suppressive functions of regulatory CD4 T cells (Tregs) are supported by a broad array of metabolic changes, providing potential therapeutic targets for immune modulation.
Wesley H Godfrey, Judy J Lee, Shruthi Shanmukha, Kaho Cho, Xiaojing Deng, Chandra Shekar R Ambati, Vasanta Putluri, Abu Hena Mostafa Kamal, Paul M Kim, Nagireddy Putluri, Michael D Kornberg   +10 more
doaj   +1 more source

Untargeted Metabolomics Reveals Dysregulation of Glycine- and Serine-Coupled Metabolic Pathways in an ALDH1L1-Dependent Manner In Vivo

Metabolites
Background: ALDH1L1 plays a crucial role in folate metabolism, regulating the flow of one-carbon groups through the conversion of 10-formyltetrahydrofolate to tetrahydrofolate and CO2 in a NADP+-dependent reaction.
Grace Fu, Sabrina Molina, Sergey A. Krupenko, Susan Sumner, Blake R. Rushing   +4 more
doaj   +1 more source

D-Serine: Potential Therapeutic Agent and/or Biomarker in Schizophrenia and Depression?

Frontiers in Psychiatry, 2019
D-Serine is a potent co-agonist at the NMDA glutamate receptor and has been the object of many preclinical studies to ascertain the nature of its metabolism, its regional and cellular distribution in the brain, its physiological functions and its ...
Mary-Anne B. MacKay, Mary-Anne B. MacKay, Maryana Kravtsenyuk, Maryana Kravtsenyuk, Rejish Thomas, Nicholas D. Mitchell, Nicholas D. Mitchell, Serdar M. Dursun, Serdar M. Dursun, Glen B. Baker, Glen B. Baker   +10 more
doaj   +1 more source

The role of l-serine and l-threonine in the energy metabolism and nutritional stress response of Trypanosoma cruzi

mSphere
l-Serine and l-threonine have versatile roles in metabolism. In addition to their use in protein synthesis, these amino acids participate in the biosynthesis pathways of other amino acids and even phospholipids.
Mayke Bezerra Alencar, Richard Marcel Bruno Moreira Girard, Marcell Crispim, Carlos Gustavo Baptista, Marc Biran, Frederic Bringaud, Ariel Mariano Silber   +6 more
doaj   +1 more source

Dietary Serine Supplementation Improves Growth Performance, Intramuscular Fat Content, and Composition of Gut Microbes and Metabolites in Growing–Finishing Pigs

Agriculture
Serine is widely involved in antioxidant synthesis, immune response, and fat metabolism. However, it remains unclear whether dietary serine supplementation affects fat deposition in the skeletal muscles of pigs.
Yiting Guo, Fang He, Zhiying Deng, Jie Yin, Guiping Guan, Zhengjun Xie, Xihong Zhou   +6 more
doaj   +1 more source

Understanding serine and glycine metabolism in cancer: a path towards precision medicine to improve patient’s outcomes

Discover Oncology
In this perspective, we highlight and reflect on the current knowledge with respect to serine/glycine metabolism in cancer, therapeutic resistance, and precision medicine opportunities for therapeutic targeting and treatment follow-up.
Anaís Sánchez-Castillo, Kim R. Kampen
doaj   +1 more source

Redox homeostasis of one-carbon metabolism-dependent reprogramming is critical for RCC progression under exogenous serine/glycine-deprived conditions

BMC Cancer
Background Serine/glycine are critical for the growth and survival of cancer cells. Some cancer cells are more dependent on exogenous serine/glycine than endogenously synthesized serine/glycine.
Huijuan Wang, Mengzhen Fan, Sichang Liu, Mengjiao Qu, Xin Hou, Junqing Hou, Yanxin Xu, Xiaodi Shang, Chen Liu, Mingxia He, Jianzheng Gao, Jingying Chen, Xia Li   +12 more
doaj   +1 more source

Serine synthesis and catabolism in starved lung cancer and primary bronchial epithelial cells

Cancer & Metabolism
Serine and glycine give rise to important building blocks in proliferating cells. Both amino acids are either synthesized de novo or taken up from the extracellular space.
Theresa Haitzmann, Katharina Schindlmaier, Tobias Frech, Ayusi Mondal, Visnja Bubalo, Barbara Konrad, Gabriele Bluemel, Philipp Stiegler, Stefanie Lackner, Andelko Hrzenjak, Thomas Eichmann, Harald C. Köfeler, Katharina Leithner   +12 more
doaj   +1 more source