Serine metabolism in tumor progression and immunotherapy [PDF]
Discover OncologySerine plays a vital role in various metabolic processes including the synthesis of proteins and other amino acids, which are essential for the cell proliferation and growth.
Dong Huang, Hui Cai, HaiYu Huang
doaj +6 more sources
Hsa_circ_0062682 Promotes Serine Metabolism and Tumor Growth in Colorectal Cancer by Regulating the miR-940/PHGDH Axis [PDF]
Frontiers in Cell and Developmental Biology, 2021 Colorectal cancer (CRC) is one of the most common malignancies globally. Increasing evidence indicates that circular RNAs (circRNAs) play a pivotal role in various cancers. The present study focused on exploring the role of a functionally unknown circRNA,
Shengbai Sun +18 more
doaj +4 more sources
SHMT2 regulates serine metabolism to promote the progression and immunosuppression of papillary renal cell carcinoma [PDF]
Frontiers in Oncology, 2022 Recent research has demonstrated the diverse relationship between tumour metabolism and the tumour microenvironment (TME), for example, abnormal serine metabolism.
Weiyu Kong +6 more
doaj +4 more sources
The role of serine metabolism in lung cancer: From oncogenesis to tumor treatment [PDF]
Frontiers in Genetics, 2023 Metabolic reprogramming is an important hallmark of malignant tumors. Serine is a non-essential amino acid involved in cell proliferation. Serine metabolism, especially the de novo serine synthesis pathway, forms a metabolic network with glycolysis ...
Xijia Zhou +4 more
doaj +2 more sources
Recent progress in serine metabolism reprogramming in tumors and strategies for serine deprivation [PDF]
Frontiers in OncologyTumor cells undergo extensive metabolic reprogramming during malignant proliferation, with serine—a key nonessential amino acid—playing multiple roles in tumor metabolism.
Huimei Liu, Huimei Liu, Yanping Liu
doaj +2 more sources
Serine Metabolism Regulates YAP Activity Through USP7 in Colon Cancer [PDF]
Frontiers in Cell and Developmental Biology, 2021 Metabolic reprogramming is a vital factor in the development of many types of cancer, including colon cancer. Serine metabolic reprogramming is a major feature of tumor metabolism.
Xiaoya Zhao +14 more
doaj +2 more sources
The role and research progress of serine metabolism in tumor cells [PDF]
Frontiers in OncologySerine is crucial for tumor initiation, progression, and adaptive immunity. Metabolic pathways for serine synthesis, acquisition, and utilization in tumors and tumor-associated cells are influenced by various physiological factors and the tumor ...
Hanning Lyu +6 more
doaj +2 more sources
Aminooxy acetic acid suppresses Th17-mediated psoriasis-like skin inflammation by inhibiting serine metabolism [PDF]
Frontiers in Pharmacology, 2023 Background: Psoriasis is a common chronic inflammatory skin disease characterized by an external red rash that is caused by abnormal proliferation and differentiation of keratinocytes and immune T cells. This study aimed to elucidate the role of aminooxy
Jong Yeong Lee +5 more
doaj +2 more sources
Impaired glycolysis-derived serine metabolism as a key driver of podocyte injury with senescence [PDF]
Nature CommunicationsChronic kidney disease (CKD) is a major health issue, with podocyte injury with senescence playing a central role in glomerulosclerosis. This study investigates the link between glycolysis-derived serine metabolism and podocyte injury with senescence ...
Hongtu Hu +12 more
doaj +2 more sources
Serine and glycine metabolism in cancer [PDF]
Trends in Biochemical Sciences, 2014 Serine and glycine are biosynthetically linked, and together provide the essential precursors for the synthesis of proteins, nucleic acids, and lipids that are crucial to cancer cell growth. Moreover, serine/glycine biosynthesis also affects cellular antioxidative capacity, thus supporting tumour homeostasis. A crucial contribution of serine/glycine to
Ivano Amelio +4 more
openalex +5 more sources