Results 131 to 140 of about 4,964 (165)

R-2-hydroxyglutarate-mediated inhibition of KDM4A compromises telomere integrity. [PDF]

Nucleic Acids Res
Couteau F, Gagné LM, Boulay K, Rousseau P, Carbonneau M, McQuaid M, Sharma J, Sawchyn C, Fernandez E, Glatz D, Rizk R, Lalonde ME, Mehrjoo Y, Chu TW, Moquin-Beaudry G, Beauséjour C, Sergeev M, Costantino S, Avizonis D, Topisirovic I, Jabado N, Wurtele H, Autexier C, Mallette FA.   +23 more
europepmc   +1 more source

Telomere attrition is common in patients with germline <i>RUNX1</i> pathogenic variants. [PDF]

Haematologica
Lawal RA, Gutierrez-Rodrigues F, Young DJ, Bresciani E, Groarke EM, Deuitch NT, McGuinness M, Craft K, Chong S, Sierk M, Meerzaman D, Patel BA, Young NS, Weng NP, Liu PP.   +14 more
europepmc   +1 more source

A CPC-shelterin-BTR axis regulates mitotic telomere deprotection. [PDF]

Nat Commun
Romero-Zamora D, Rogers S, Low RRJ, Page SG, Lane BJE, Kosaka S, Robinson AB, French L, Lamm N, Ishikawa F, Hayashi MT, Cesare AJ.   +11 more
europepmc   +1 more source

Human RPA is an essential telomerase processivity factor for maintaining telomeres. [PDF]

Science
Agrawal S, Lin X, Susvirkar V, O'Connor MS, Chavez BL, Tholkes VR, Tauber GP, He Q, Abe KM, Huang X, Lim CJ.   +10 more
europepmc   +1 more source

Modified hTERT treatment ameliorates pressure overload-induced heart failure. [PDF]

EBioMedicine
Zhao Y, Bao X, Xiong W, Wan X, Yu Q, Wang T, Chang ACH, Liu Y, Wang Y, Shang C, Wu M, Ashley EA, Lei M, Zhang J, Wu Y, Han W, Chang ACY.   +16 more
europepmc   +1 more source

The forbidden doubling: exploring rare spermatocyte polyploidy in mammals. [PDF]

Comp Cytogenet
Matveevsky S, Kolomiets O, Grishaeva T, Bogdanov A, Tambovtseva V, Bakloushinskaya I.   +5 more
europepmc   +1 more source

Shelterin is a dimeric complex with extensive structural heterogeneity [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2022
Abstract Human shelterin is a six-subunit complex – comprised of TRF1, TRF2, Rap1, TIN2, TPP1, and POT1 – that binds telomeres, protects them from the DNA-damage response, and regulates the maintenance of telomeric DNA. Although high-resolution structures have been generated of the individual structured domains within shelterin, the ...
John C Zinder, Paul Dominic B Olinares, Evgeny Nudler   +2 more
exaly   +3 more sources

Role of shelterin in cancer and aging [PDF]

Aging Cell, 2010
SummaryMammalian telomeres are formed by tandem repeats of the TTAGGG sequence bound by a specialized six‐protein complex known as shelterin, which has fundamental roles in the regulation of telomere length and telomere capping. In the past, the study of mice genetically modified for telomerase components has been instrumental to demonstrate the role ...
Paula Martinez, Maria A Blasco
exaly   +3 more sources

Structural Basis for Shelterin Bridge Assembly [PDF]

Molecular Cell, 2017
Telomere elongation through telomerase enables chromosome survival during cellular proliferation. The conserved multifunctional shelterin complex associates with telomeres to coordinate multiple telomere activities, including telomere elongation by telomerase.
Jin-Kwang Kim, Jinqiang Liu, Clinton Yu   +2 more
exaly   +5 more sources

The Altered Functions of Shelterin Components in ALT Cells

International Journal of Molecular Sciences, 2023
Telomeres are nucleoprotein complexes that cap the ends of eukaryotic linear chromosomes. Telomeric DNA is bound by shelterin protein complex to prevent telomeric chromosome ends from being recognized as damaged sites for abnormal repair. To overcome the end replication problem, cancer cells mostly preserve their telomeres by reactivating telomerase ...
Shuting Jia
exaly   +3 more sources