Results 141 to 150 of about 4,964 (165)

Shelterin-Mediated Telomere Protection

Annual Review of Genetics, 2018
For more than a decade, it has been known that mammalian cells use shelterin to protect chromosome ends. Much progress has been made on the mechanism by which shelterin prevents telomeres from inadvertently activating DNA damage signaling and double-strand break (DSB) repair pathways.
Titia De Lange
exaly   +3 more sources

Telomere Recognition and Assembly Mechanism of Mammalian Shelterin

Cell Reports, 2017
Shelterin is a six-subunit protein complex that plays crucial roles in telomere length regulation, protection, and maintenance. Although several shelterin subunits have been studied in vitro, the biochemical properties of the fully assembled shelterin complex are not well defined.
Fabian Erdel, Smaranda Willcox, Jack D Griffith   +2 more
exaly   +3 more sources

Impact of shelterin complex on telomere accessibility

Biophysical Journal, 2022
ABSTRACT Shelterin plays critical roles in maintaining and protecting telomeres by regulating access of various physiological agents to telomeric DNA. We present single molecule measurements investigating the impact of the POT1 and a four-component shelterin complex on the accessibility of human telomeric DNA overhangs with ...
Sajad Shiekh, Amanda Jack, Golam Mustafa, Sineth G. Kodikara, Prabesh Gyawali, Mohammed Enamul Hoque, Ahmet Yildiz, Hamza Balci   +7 more
openaire   +1 more source

What I got wrong about shelterin [PDF]

Journal of Biological Chemistry, 2018
The ASBMB 2018 Bert and Natalie Vallee award in Biomedical Sciences honors our work on shelterin, a protein complex that helps cells distinguish the chromosome ends from sites of DNA damage. Shelterin protects telomeres from all aspects of the DNA damage response, including ATM and ATR serine/threonine kinase signaling and several forms of double ...
Titia De Lange
exaly   +3 more sources

How Shelterin Protects Mammalian Telomeres

Annual Review of Genetics, 2008
The genomes of prokaryotes and eukaryotic organelles are usually circular as are most plasmids and viral genomes. In contrast, the nuclear genomes of eukaryotes are organized on linear chromosomes, which require mechanisms to protect and replicate DNA ends.
Wilhelm, Palm, Titia, de Lange
openaire   +2 more sources

Shelterin and the replisome: at the intersection of telomere repair and replication

Current Opinion in Genetics & Development, 2020
Telomeres are G-rich repetitive sequences that are difficult to replicate, resulting in increased replication stress that can threaten genome stability. Shelterin protects telomeres from engaging in aberrant DNA repair and dictates the choice of DNA repair pathway at dysfunctional telomeres. Recently, shelterin has been shown to participate in telomere
Alessandro, Cicconi, Sandy, Chang
openaire   +2 more sources

Shelterin complex at telomeres: Roles in cancers

Gene Reports, 2021
Abstract Telomeres, the nucleoprotein structures at the ends of eukaryotic chromosomes, have multiple roles in tumorigenesis. The shelterin complex consists of six telomere-specific proteins that are involved in the protection of the telomeres. The shelterin complex protects the telomeres from degradation, prevents the activation of unwanted repair ...
Emad Khodadadi, Seyed Mostafa Mir, Mohammad Yousef Memar, Hossein Sadeghi, Meysam Kashiri, Mehri Faeghiniya, Zahra Jamalpoor, Mehdi Sheikh Arabi   +7 more
openaire   +1 more source

Targeting shelterin proteins for cancer therapy

Drug Discovery Today
As a global health challenge, cancer prompts continuous exploration for innovative therapies that are also based on new targets. One promising avenue is targeting the shelterin protein complex, a safeguard for telomeres crucial in preventing DNA damage.
Anoop Kallingal, Maciej Bagiński
exaly   +3 more sources

Shelterin Proteinleri: Telomerlerin Koruyucu Kalkanı

2023
Ökaryotik kromozomların uçlarında bulunan telomerler, guanince zengin tandem TTAGGG amino asit dizilerinden oluşan DNA uzantılarıdır. TERF1/TRF1, TERF2/TRF2, POT1, TINF2/TIN2, TPP1, TERF2IP/RAP1’den oluşan telomere özgü altı protein shelterin kompleksi proteinleri olarak adlandırılır.
Mustafa Doğan Bedir, Deniz Bakır
openaire   +1 more source

Le complexe shelterine

La protection des extrémités des chromosomes eucaryotes est vitale pour la stabilité du génome. Chez les mammifères, le complexe Shelterine est responsable de cette protection car il inhibe la réponse aux cassures double brin et les machineries de réparation.
Claire GHILAIN, Éric GILSON, Marie-Josèphe GIRAUD-PANIS   +2 more
openaire   +1 more source