Results 91 to 100 of about 15,124 (230)

Crystallographic studies of shikimate binding and induced conformational changes in Mycobacterium tuberculosis shikimate kinase [PDF]

The X-ray crystal structure of Mycobacterium tuberculosis shikimate kinase (SK) with bound shikimate and adenosine diphosphate (ADP) has been determined to a resolution of 2.15 Å.
Dhaliwal B, Nichols CE, Lockyer M, Charles I, Ren J, Stammers DK, Hawkins AR   +6 more
core  

Cell‐Specific Expression and Cellular Compartmental Regulation in Camptothecin Biosynthesis

Plant Biotechnology Journal, Volume 24, Issue 9, Page 5114-5130, September 2026.
ABSTRACT Plant secondary metabolites such as monoterpenoid indole alkaloids (MIAs) show tightly regulated biosynthesis and accumulation in specific organelles of distinct cell types. However, the cell‐specific expression patterns of anticancer MIA camptothecin biosynthetic genes in Ophiorrhiza pumila and the regulatory mechanisms of camptothecin ...
Xiaolong Hao, Yinkai Yang, Tiantian Chen, Xiaoxuan Fan, Yiqing Peng, Qingyan Ruan, Qin Zhou, Fanghao Liu, Jiayi He, Yongpeng Li, Yue Feng, Jiyan Qi, Guoyin Kai   +12 more
wiley   +1 more source

Biosensor-guided improvements in salicylate production by recombinant Escherichia coli

Microbial Cell Factories, 2019
Background Salicylate can be biosynthesized from the common metabolic intermediate shikimate and has found applications in pharmaceuticals and in the bioplastics industry.
Shuai Qian, Ye Li, Patrick C. Cirino
doaj   +1 more source

Supervised Restricted Data Fusion With Common, Local, and Distinct Components

Journal of Chemometrics, Volume 40, Issue 8, August 2026.
ABSTRACT In multi‐block data, the dominant sources of variation are not always most relevant to a response of interest, meaning that purely exploratory decompositions may fail to recover subtle but important response‐associated structure. We introduce PESCAR, a supervised extension of Penalised Exponential Simultaneous Component Analysis (PESCA) that ...
Fred T. G. White, Geert Roelof van der Ploeg, Anna Heintz‐Buschart, Lemeng Dong, Harro J. Bouwmeester, Age K. Smilde, Johan A. Westerhuis   +6 more
wiley   +1 more source

A CRITICAL INSIGHT INTO SHIKIMATE KINASE PATHWAY [PDF]

, 2015
Objective: Tuberculosis is the most infectious disease that appears to be dreadful even in the presence of anti tubercular drugs. The problem of MDR-TB is growing at an alarming rate and the prevalence of the disease cause devastation to the molecular ...
Mehta, Sandhya S., Mehta, Shashidhar, Patyal, Pankaj, Thokchom, Suresh K., Bhatnagar, Suhasini   +4 more
core  

Innovating a Nonconventional Yeast Platform for Producing Shikimate as the Building Block of High-Value Aromatics [PDF]

, 2016
The shikimate pathway serves an essential role in many organisms. Not only are the three aromatic amino acids synthesized through this pathway, but many secondary metabolites also derive from it.
Adam Okerlund (3130596), Natalia Rodriguez Quiroz (3130587), Yutong Wu (3130584), Levi Stanley (3070905), Jacqueline V. Shanks (529246), Miguel Suástegui (3130593), James Walker (525818), Dana Tribby (3130581), Zengyi Shao (1883758), Meirong Gao (3130590), Mingfeng Cao (577797)   +10 more
core   +1 more source

The conserved Lysine69 residue plays a catalytic role in Mycobacterium tuberculosis shikimate dehydrogenase

BMC Research Notes, 2009
Background The shikimate pathway is an attractive target for the development of antitubercular agents because it is essential in Mycobacterium tuberculosis, the causative agent of tuberculosis, but absent in humans. M. tuberculosis aroE-encoded shikimate
Rodrigues Valnês, Breda Ardala, Santos Diógenes, Basso Luiz   +3 more
doaj  

Stage‐Specific Metabolic and Proteomic Dynamics Underlying Ripening and Quality Formation in Tropical Evergreen Pomegranate

eFood, Volume 7, Issue 4, August 2026.
Integrated multi‐omics reveals that pomegranate ripening between 90 and 130 days drives optimal sugar‐acid balance and pigmentation via coordinated regulation of phenylpropanoid, flavonoid, and carbohydrate metabolism pathways. ABSTRACT Pomegranate fruit development involves coordinated physiological, metabolic, and proteomic changes shaping coloration
Yawen Zhang, Ling Wei, Kaibing Zhou, Qin Deng, Muhammad Mobeen Tahir, Hongxia Wu, Minjie Qian   +6 more
wiley   +1 more source

Gallic Acid: A Potent Metabolite Targeting Shikimate Kinase in Acinetobacter baumannii

Metabolites
Background/Objectives: Acinetobacter baumannii is a highly multidrug-resistant pathogen resistant to almost all classes of antibiotics; new therapeutic strategies against this infectious agent are urgently needed.
Mansour S. Alturki, Abdulaziz H. Al Khzem, Mohamed S. Gomaa, Nada Tawfeeq, Marwah H. Alhamadah, Futun M. Alshehri, Raghad Alzahrani, Hanin Alghamdi, Thankhoe A. Rants’o, Khaled A. G. Ayil, Abdulaziz K. Al Mouslem, Mohammed Almaghrabi   +11 more
doaj   +1 more source

Bioaccessibility of Phytochemicals, Amino Acids, Antioxidant Capacity, and Enzyme Inhibitory Activities of Hawthorn (Crataegus spp.) Fruits Following INFOGEST Simulated Gastrointestinal Digestion

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
Comprehensive compositional and functional characterization of three Crataegus species demonstrated that simulated gastrointestinal digestion substantially altered the bioaccessibility of phenolic compounds and associated biological activities. The pronounced interspecific variation observed highlights the importance of species selection for the ...
Kubra Feyza Erol, Gozde Kutlu, Hatice Bekiroglu, Osman Sagdıc, Fatih Tornuk   +4 more
wiley   +1 more source