Native functions of short tandem repeats [PDF]
eLife, 2023 Over a third of the human genome is comprised of repetitive sequences, including more than a million short tandem repeats (STRs). While studies of the pathologic consequences of repeat expansions that cause syndromic human diseases are extensive, the ...
Shannon E Wright, Peter K Todd
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Short tandem repeats delineate gene bodies across eukaryotes [PDF]
Nature CommunicationsShort tandem repeats (STRs) have emerged as important and hypermutable sites where genetic variation correlates with gene expression in plant and animal systems.
William B. Reinar +4 more
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Evolutionary Study of Protein Short Tandem Repeats in Protein Families [PDF]
Biomolecules, 2023 Tandem repeats in proteins are patterns of residues repeated directly adjacent to each other. The evolution of these repeats can be assessed by using groups of homologous sequences, which can help pointing to events of unit duplication or deletion.
Pablo Mier, Miguel A. Andrade-Navarro
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Genome-wide selection inference at short tandem repeats. [PDF]
PLoS GeneticsShort tandem repeats (STRs) comprising repeated sequences of 1-6 bp are one of the largest sources of genetic variation in humans. STRs are known to contribute to a variety of disorders, including Mendelian diseases, complex traits, and cancer.
Bonnie Huang +6 more
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The Genomic landscape of short tandem repeats across multiple ancestries [PDF]
PLoS ONE, 2023 Short Tandem Repeats (STRs) have been found to play a role in a myriad of complex traits and genetic diseases. We examined the variability in the lengths of over 850,000 STR loci in 996 children with suspected genetic disorders and 1,178 parents across ...
Prashanth Vijayaraghavan +7 more
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The mutational dynamics of short tandem repeats in large, multigenerational families [PDF]
Genome Biology, 2022 Background Short tandem repeats (STRs) compose approximately 3% of the genome, and mutations at STR loci have been linked to dozens of human diseases including amyotrophic lateral sclerosis, Friedreich ataxia, Huntington disease, and fragile X syndrome ...
Cody J. Steely +3 more
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Evaluation of genetic instability of short tandem repeats in hepatocellular carcinoma [PDF]
Scientific ReportsHepatocellular carcinoma (HCC) ranked as the sixth most common malignancy and the third leading cause of cancer-related mortality with approximately 830, 000 deaths worldwide annually.
Yinghui Song +4 more
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The repertoire of short tandem repeats across the tree of life [PDF]
Genome BiologyBackground Short tandem repeats (STRs) are widespread, dynamic repetitive elements with a number of biological functions and relevance to human diseases, genome plasticity and adaptation. However, their prevalence across taxa remains poorly characterized.
Nikol Chantzi +1 more
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Mutations of short tandem repeats explain abundant trait heritability in Arabidopsis [PDF]
Genome BiologyBackground Short tandem repeat (STR) mutations are major drivers of genetic variation and deeply influence phenotypic diversity and evolution, they are often overlooked despite their significant effects.
Zhi-Qin Zhang +6 more
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Genotyping short tandem repeats across copy number alterations, aneuploidies, and polyploid organisms [PDF]
Communications BiologyShort tandem repeats (STRs) are a rich source of genetic variation, but are difficult to genotype. While specialized repeat variant callers exist, they typically assume a euploid human genome.
Max A. Verbiest +3 more
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