Results 31 to 40 of about 61,394 (249)

Short Tandem Repeats (STR) in cattle genomics and breeding [PDF]

open access: yesBiotechnology in Animal Husbandry, 2018
Molecular markers are essential tool for determining the specific genetic makeup of an individual and are valuable approach for genetic improvement of farm animals.
Teneva Atanaska   +7 more
doaj  

Genetic investigation of the origin of an allograft ureteral carcinoma with short tandem repeats: From recipient or donor?

open access: yesUrological Science, 2023
Purpose: The purpose of this study was to demonstrate the usefulness of genetic analysis with short tandem repeats (STRs) to identify the cellular origin of an unusual allograft urothelial carcinoma (UC).
Jia-Yuh Sheu   +4 more
doaj   +1 more source

Link between short tandem repeats and translation initiation site selection

open access: yesHuman Genomics, 2018
Background Despite their vast biological implication, the relevance of short tandem repeats (STRs)/microsatellites to the protein-coding gene translation initiation sites (TISs) remains largely unknown.
Masoud Arabfard   +3 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Comprehensive Insights Into Forensic Features and Genetic Background of Chinese Northwest Hui Group Using Six Distinct Categories of 231 Molecular Markers

open access: yesFrontiers in Genetics, 2021
The Hui minority is predominantly composed of Chinese-speaking Islamic adherents distributed throughout China, of which the individuals are mainly concentrated in Northwest China.
Chong Chen   +18 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Short tandem repeats genotyping of gestational choriocarcinoma – our experiences

open access: yesTaiwanese Journal of Obstetrics & Gynecology
Objective: This short communication demonstrates how short tandem repeat genotyping can identify the origin of gestational choriocarcinoma. Materials and methods: The origin of gestational choriocarcinoma in our three cases was determined using the short
Lajos Gergely   +8 more
doaj   +1 more source

Microsatellite Stability in STR Analysis Aspergillus fumigatus Depends on Number of Repeat Units

open access: yesFrontiers in Cellular and Infection Microbiology, 2019
More than a decade ago a short tandem repeat-based typing method was developed for the fungus Aspergillus fumigatus. This STRAf assay is based on the analysis of nine short tandem repeat markers.
Theun de Groot   +3 more
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

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