Results 61 to 70 of about 113,461 (351)
Advanced Functional Materials, EarlyView.This study presents a microfluidic brain microvascular network‐on‐chip (BMVasChip) to investigate endothelial barrier dysfunction caused by flavivirus non‐structural protein 1 (NS1), including virus‐ and time‐dependent vascular damage, leakiness, and dysfunction.
Monika Rajput +5 more
wiley +1 more source
SensorsAn overexpression of sialic acid is an indicator of metastatic cancer, and selective detection of sialic acid shows potential for cancer diagnosis. Boronic acid is a promising candidate for this purpose because of its ability to specifically bind to ...
Yukichi Horiguchi +4 more
doaj +1 more source
Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes
Advanced Functional Materials, EarlyView.Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth +2 more
wiley +1 more source
Structures of B-lymphotropic polyomavirus VP1 in complex with oligosaccharide ligands. [PDF]
PLoS Pathogens, 2013 B-Lymphotropic Polyomavirus (LPyV) serves as a paradigm of virus receptor binding and tropism, and is the closest relative of the recently discovered Human Polyomavirus 9 (HPyV9).
Ursula Neu +7 more
doaj +1 more source
DNA-binding transferrin conjugates as functional gene-delivery agents: synthesis by linkage of polylysine or ethidium homodimer to the transferrin carbohydrate moiety [PDF]
, 1991 We have previously demonstrated that transferrin-polycation conjugates are efficient carrier molecules for the introduction of genes into eucariotic cells.
Birnstiel, Max L. +4 more
core +1 more source
Sialic acid glycoengineering using N-acetylmannosamine and sialic acid analogs
Glycobiology, 2019 Sialic acids cap the glycans of cell surface glycoproteins and glycolipids. They are involved in a multitude of biological processes and aberrant sialic acid expression is associated with several pathologies. Sialic acids modulate the characteristics and functions of glycoproteins and regulate cell-cell as well as cell-extracellular matrix interactions.
Sam J Moons +4 more
openaire +4 more sources
Sialic Acid Receptors of Viruses [PDF]
, 2013 Sialic acid linked to glycoproteins and gangliosides is used by many viruses as a receptor for cell entry. These viruses include important human and animal pathogens, such as influenza, parainfluenza, mumps, corona, noro, rota, and DNA tumor viruses.
Georg Herrler +2 more
openaire +3 more sources
Advanced Healthcare Materials, EarlyView.Membrane fusion‐inspired nanomaterials offer transformative potential in diagnostics by mimicking natural fusion processes to achieve highly sensitive and specific detection of disease biomarkers. This review highlights recent advancements in nanomaterial functionalization strategies, signal amplification systems, and stimuli‐responsive fusion designs,
Sojeong Lee +9 more
wiley +1 more source
A study to assess serum and tissue levels of sialic acid and hexosamine in keloids
MRIMS Journal of Health Sciences, 2015 Background: A keloid is an abnormal proliferation of scar tissue that forms at the site of cutaneous injury. The major component of scar tissue is the fibrous protein collagen, which is a glycoprotein.
M Girija Menon +3 more
doaj +1 more source
Specific synthesis of neurostatin and gangliosides O-acetylated in the outer sialic acids using a sialate transferase. [PDF]
PLoS ONE, 2012 Gangliosides are sialic acid containing glycosphingolipids, commonly found on the outer leaflet of the plasma membrane. O-acetylation of sialic acid hydroxyl groups is one of the most common modifications in gangliosides.
Lorenzo Romero-Ramírez +6 more
doaj +1 more source