Results 71 to 80 of about 116,138 (312)

Mice lacking sialyltransferase ST3Gal-II develop late-onset obesity and insulin resistance [PDF]

, 2016
Sialyltransferases are a family of 20 gene products in mice and humans that transfer sialic acid from its activated precursor, CMP-sialic acid, to the terminus of glycoprotein and glycolipid acceptors.
Aja, Susan, Aoki, Kazuhiro, Lei, Xia, Lopez, Pablo, Ronnett, Gabriele V, Schnaar, Ronald L., Seldin, Marcus M., Wong, G. William   +7 more
core   +1 more source

Generation of an Induced Pluripotent Stem Cell‐Derived Alveolar Type II In Vitro Model to Study Influenza A Virus Infection and Drug Treatments

Advanced Healthcare Materials, EarlyView.
Patient‐specific induced pluripotent stem cells (iPSCs) can be differentiated into alveolar type II cells (iAT2s), expanded as 3D alveolospheres, and grown at physiologically relevant air–liquid interface (ALI). This study shows for the first time the infectability of iAT2s by the influenza A virus (IAV) and proves their responsiveness to the well ...
Lena Gauthier, Hristina Koceva, Yann Bachelot, Rosanne W. Koutstaal, Puck B. van Kasteren, Marc Thilo Figge, Christian Eggeling, Alexander Sandy Mosig   +7 more
wiley   +1 more source

Structures of B-lymphotropic polyomavirus VP1 in complex with oligosaccharide ligands. [PDF]

PLoS Pathogens, 2013
B-Lymphotropic Polyomavirus (LPyV) serves as a paradigm of virus receptor binding and tropism, and is the closest relative of the recently discovered Human Polyomavirus 9 (HPyV9).
Ursula Neu, Zaigham Mahmood Khan, Benjamin Schuch, Angelina S Palma, Yan Liu, Michael Pawlita, Ten Feizi, Thilo Stehle   +7 more
doaj   +1 more source

Clinical application of sialic acid (II) Sialic acid contents in cerebro-spinal fluid of patients suffering from the disease of the central nervous system [PDF]

, 1959
It is well known that human serum contains some sialic acid and its contents increase markedly in the blood serum of the patients bearing malignant tumors.
Kanbayashi, Tsuneo, Kawakami, Hiroshi, Saito, Kunio, Yamaguchi, Michiya   +3 more
core   +1 more source

Membrane Fusion‐Inspired Nanomaterials: Emerging Strategies for Infectious Disease and Cancer Diagnostics

Advanced Healthcare Materials, EarlyView.
Membrane fusion‐inspired nanomaterials offer transformative potential in diagnostics by mimicking natural fusion processes to achieve highly sensitive and specific detection of disease biomarkers. This review highlights recent advancements in nanomaterial functionalization strategies, signal amplification systems, and stimuli‐responsive fusion designs,
Sojeong Lee, Khulan Nyamzaya, Jueun Han, Yejin Song, Jihee Lee, Jung Hyun Jo, Seungmin Bang, Eun‐Kyung Lim, Seungjoo Haam, Eunjung Kim   +9 more
wiley   +1 more source

Spatiotemporal expression patterns of sialoglycoconjugates during nephron morphogenesis and their regional and cell type-specific distribution in adult rat kidney [PDF]

, 2018
The expression of α2,6- and α2,3-linked sialic acids on N-glycans was studied in embryonic, postnatal, and adult rat kidney. Histochemistry and blotting using Polyporus squamosus and Sambucus nigra lectins for α2,6-linked sialic acids and the Maackia ...
Goldstein, Irwin, Paulson, James, Roth, Jürgen, Toma, Valeriu, Winter, Harry, Zuber, Christian   +5 more
core  

Kelvin Probe Force Microscopy in Bionanotechnology: Current Advances and Future Perspectives

Advanced Materials, EarlyView.
Kelvin probe force microscopy (KPFM) enables the nanoscale mapping of electrostatic surface potentials. While widely applied in materials science, its use in biological systems remains emerging. This review presents recent advances in KPFM applied to biological samples and provides a critical perspective on current limitations and future directions for
Ehsan Rahimi, Mario Palacios‐Corella, Arjan Mol, Salvador Pané, Josep Puigmartí‐Luis   +4 more
wiley   +1 more source

Specific synthesis of neurostatin and gangliosides O-acetylated in the outer sialic acids using a sialate transferase. [PDF]

PLoS ONE, 2012
Gangliosides are sialic acid containing glycosphingolipids, commonly found on the outer leaflet of the plasma membrane. O-acetylation of sialic acid hydroxyl groups is one of the most common modifications in gangliosides.
Lorenzo Romero-Ramírez, Isabel García-Álvarez, Ramón Campos-Olivas, Michel Gilbert, Marie-France Goneau, Alfonso Fernández-Mayoralas, Manuel Nieto-Sampedro   +6 more
doaj   +1 more source

High-Level Expression of Various Apolipoprotein (a) Isoforms by "Transferrinfection". The Role of Kringle IV Sequences in the Extracellular Association with Low-Density Lipoprotein [PDF]

, 1994
Characterization of the assembly of lipoprotein(a) [Lp(a)] is of fundamental importance to understanding the biosynthesis and metabolism of this atherogenic lipoprotein. Since no established cell lines exist that express Lp(a) or apolipoprotein(a) [apo(a)
Azrolan N., Boerwinkle E., Brunner C., Chiesa G., Chung B. Y., Cotten M., Deutscher S. L., Deutscher S. L., Dieplinger H., Edelberg J. M., Green S., Griffiths G., Guevara J., Jr., Huby T., Ichinose A., Kamboh M. I., Koschinsky M. L., Koschinsky M. L., Koschinsky M. L., Kostner G. M., Kraft H- G., Kraft H. G., Krempler F., Krempler F., Lackner C., Linton M. F., Malgaretti N., McGregor G. R., McLean J. W., Menzel H. J., Phillips M. L., Rader D. J., Sambrook J., Sandholzer C., Scanu A. M., Selden R. F., Sommer A., Stanley P., Trieu V. N., Utermann G., Utermann G., Utermann G., Wagner E., White A. L., Zatloukal K., Zechner R„   +45 more
core   +1 more source

Glycosidation of sialic acid.

Journal of Synthetic Organic Chemistry, Japan, 1989
N-Acetylneuraminic acid (Neu5Ac), a typical sialic acid, located at the non-reducing ends of carbohydrate chains of glycoproteins and glycolipids plays an important role in biological phenomena. The synthesis of oligosaccharides which contain Neu5Ac has focused with clarification of their vital functions.
Kaoru Okamoto, Toshio Goto
openaire   +2 more sources