Results 1 to 10 of about 91,775 (139)

-escin mitigates neuroinflammation and apoptosis caused by ischemic stroke through the inhibition of the interleukin-6/Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway [PDF]

Journal of International Medical Research
Objective This study aimed to investigate the protective effects of β-escin against neuroinflammatory injury and its influence on the interleukin-6/Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway in a rat model of ...
Duan Yanqin, Liu Shenglan, Zhang Yu, Deng Yu, Du Qing, Zeng Hongliang, Tan Dianbo, Liu Chunhai, Yin yong, Liu Dongliang   +9 more
doaj   +2 more sources

Signal Transducer and Activator of Transcription 4 (STAT4) Association with Pituitary Adenoma [PDF]

Medicina
Background/Objectives: This study aims to investigate whether Signal Transducer and Activator of Transcription 4 (STAT4) influences the anti-tumor immune response and is possibly involved in the initiation or relapse of pituitary adenomas (PAs) by ...
Greta Gedvilaite-Vaicechauskiene, Loresa Kriauciuniene, Rasa Liutkeviciene   +2 more
doaj   +2 more sources

Signal Transducer and Activator of Transcription Proteins at the Nexus of Immunodeficiency, Autoimmunity and Cancer [PDF]

Biomedicines, 2023
The signal transducer and activator of transcription (STAT) family of proteins has been demonstrated to perform pivotal roles downstream of a myriad of cytokines, particularly those that control immune cell production and function. This is highlighted by
Clifford Liongue, Mohamed Luban Sobah, Alister C. Ward   +2 more
doaj   +2 more sources

A Rare Mesenchymal Neoplasm at an Uncommon Anatomical Site- Solitary Fibrous Tumour of Vulva [PDF]

Journal of Clinical and Diagnostic Research, 2022
Previously, Solitary Fibrous Tumour (SFT) was thought to originate from the pleura, a relatively rare mesenchymal neoplasm with an indolent course. Vulva is a very uncommon site of extrathoracic SFT. This is a report of a very uncommon case of vulval SFT
Nupur Kaushik, Lalit Kumar, Prashant Singh, Juhi Singhal   +3 more
doaj   +1 more source

NT157 Inhibits HCC Migration via Downregulating the STAT3/Jab1 Signaling Pathway

Technology in Cancer Research & Treatment, 2021
Purpose: The high fatality-to-case ratio of hepatocellular carcinoma is directly related to metastasis. The signal transducer and activator of transcription-3 is a key mediator of the cytokine and growth factor signaling pathways and drives the ...
SiZhe Yu, Yu Wang, KeJia Lv, Jia Hou, WenYuan Li, Xiao Wang, Hui Guo, WenJuan Wang   +7 more
doaj   +1 more source

Clinicopathological significance of protein disulphide isomerase A3 and phosphorylated signal transducer and activator of transcription 3 in cervical carcinoma [PDF]

Contemporary Oncology
Asmaa Abdullatif, Aziza E. Abdelrahman, Adel Bakry, Shimaa A. Gharieb, Mohamed Sh. Ramadan, Mohamed A. Wasfy, Abdelfatah H. Abdelwanis, Enas M. Fouad   +7 more
doaj   +2 more sources

Special Issue “Role of STAT3 in Oncogenesis”

Biomedicines, 2022
This Biomedicines Special Issue was designed to attract articles that focused on the pleiotropic role of the signal transducer and activator of transcription 3 (STAT3) transcription factor in different facets of tumorigenesis [...]
Kwang Seok Ahn
doaj   +1 more source

Oncogenic Mutations and Gene Fusions in CD30-Positive Lymphoproliferations and Clonally Related Mycosis Fungoides Occurring in the Same Patients

JID Innovations, 2021
The emergence of a common progenitor cell has been postulated for the association of CD30-positive lymphoproliferative disease (LPD) and mycosis fungoides (MF) within the same patient.
Marion Wobser, Sabine Roth, Silke Appenzeller, Hermann Kneitz, Matthias Goebeler, Eva Geissinger, Andreas Rosenwald, Katja Maurus   +7 more
doaj   +1 more source

Research progress on the role of STAT in the pathogenesis of dermatosis [PDF]

Jichu yixue yu linchuang, 2021
Signal transducer and activator of transcription (STAT) proteins with transcriptional activity, which are involved in the pathogenesis and formation of skin lesions of atopic dermatitis, psoriasis, skin tumors and other dermatosis, and are related to the
ZHOU Qiong-yan, LIN Wei, XU Su-ling, ZHAO Ke-yu
doaj  

Janus kinases: dermatological perspective, a review

Journal of the Egyptian Women’s Dermatologic Society, 2020
Janus kinases (JAKs) are a group of nonreceptor intracellular tyrosine kinases that could modify cytokine-mediated signals through the JAK-signal transducer and activator of transcription pathway.
Hanan R Nada, Maha F Elmasry, Dina A El Sharkawy, Sally Mamdouh   +3 more
doaj   +1 more source