Results 11 to 20 of about 91,795 (159)

Kynurenine–PARP-1 Link Mediated by MicroRNA 210 May Be Dysregulated in Pulmonary Hypertension

Anatolian Journal of Cardiology, 2022
Background: Dysregulation of microRNAs is associated with pulmonary hypertension. The present study aimed to determine the alterations in microRNA and microRNA expressions and their role in signaling pathways and investigate the relationship with serum ...
Alperen Emre Akgun, Yalın Tolga Yaylalı, Mücahit Seçme, Yavuz Dodurga, Hande Şenol   +4 more
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STATs: Signal Transducers and Activators of Transcription [PDF]

Cell, 1996
One might anticipate exciting new information regarding the STATs in several areas. First, several intriguing questions remain regarding STAT structure. Given the nature of the proposed intermolecular SH2–phosphotyrosine interactions and the requirement for the interaction of the DNA-binding domains (try making models), the molecular structures of the ...
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Signal Transducer and Activator of Transcription 3 [PDF]

Current Opinion in Hematology, 2016
Signal transducer and activator of transcription 3 (STAT3) is an important transcription factor involved in a wide variety of cellular functions. Germline loss-of-function mutations are known to cause hyper-IgE immunodeficiency (autosomal dominant hyper IgE syndrome), whereas somatic gain-of-function mutations have been described in large granular cell
Lisa R, Forbes, Josh, Milner, Elie, Haddad   +2 more
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Role of JAK-STAT signaling pathway in pathogenesis and treatment of primary Sjögren's syndrome

Chinese Medical Journal, 2023
. Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease with high prevalence and possible poor prognosis. Though the pathogenesis of pSS has not been fully elucidated, B cell hyperactivity is considered as one of the fundamental abnormalities
Mucong Li, Mengtao Li, Lin Qiao, Chanyuan Wu, Dong Xu, Yan Zhao, Xiaofeng Zeng, Lishao Guo   +7 more
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The relationship between microRNAs and the STAT3-related signaling pathway in cancer

Tumor Biology, 2017
MicroRNAs are non-coding RNAs that regulate gene expression by targeting messenger RNA molecules in 3′ untranslated region. Mounting evidence indicates that microRNAs regulate several factors to influence various biological activities that are related to
Lin Zhang, Junyao Li, Qi Wang, Guangping Meng, Xuejiao Lv, Hong Zhou, Wei Li, Jie Zhang   +7 more
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Basics of Janus kinases: a review

Journal of the Egyptian Women’s Dermatologic Society, 2020
Janus kinases (JAKs) are a group of nonreceptor intracellular tyrosine kinases that could modify cytokine-mediated signals through the JAK-signal transducer and activator of transcription (STAT) pathway. The intracellular signaling pathway JAK/STAT has a
Hanan R Nada, Maha F Elmasry, Dina A El Sharkawy, Sally Mamdouh   +3 more
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Indole-3-carbinol induces apoptosis of chronic myelogenous leukemia cells through suppression of STAT5 and Akt signaling pathways

Tumor Biology, 2017
Signal transducer and activator of transcription 5 and Akt pathways, implicated in signaling transduction downstream of BCR–ABL, play critical roles in the pathogenesis of chronic myeloid leukemia.
Majid Safa, Leila Jafari, Fatemeh Alikarami, Rima Manafi Shabestari, Ahmad Kazemi   +4 more
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Flurbiprofen ameliorates glucose deprivation-induced leptin resistance

Frontiers in Pharmacology, 2016
Leptin resistance is one of the mechanisms involved in the pathophysiology of obesity. The present study showed that glucose deprivation inhibited leptin-induced phosphorylation of signal transducer and activator of transcription 3 (STAT3) and signal ...
Toru Hosoi, Yuka Suyama, Takaaki Kayano, Koichiro Ozawa   +3 more
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Kinome and Transcriptome Profiling Reveal Broad and Distinct Activities of Erlotinib, Sunitinib, and Sorafenib in the Mouse Heart and Suggest Cardiotoxicity From Combined Signal Transducer and Activator of Transcription and Epidermal Growth Factor Receptor Inhibition

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundMost novel cancer therapeutics target kinases that are essential to tumor survival. Some of these kinase inhibitors are associated with cardiotoxicity, whereas others appear to be cardiosafe.
Timothy J. Stuhlmiller, Jon S. Zawistowski, Xin Chen, Noah Sciaky, Steven P. Angus, Sean T. Hicks, Traci L. Parry, Wei Huang, Ju Youn Beak, Monte S. Willis, Gary L. Johnson, Brian C. Jensen   +11 more
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S-Glutathionylation Impairs Signal Transducer and Activator of Transcription 3 Activation and Signaling [PDF]

Endocrinology, 2008
S-glutathionylation is a physiological, reversible protein modification of cysteine residues with glutathione in response to mild oxidative stress. Because the key cell growth regulator signal transducer and activator of transcription (STAT) 3 is particularly susceptible to redox regulation, we hypothesized that oxidative modification of cysteine ...
Yi, Xie, Sutapa, Kole, Patricia, Precht, Michael J, Pazin, Michel, Bernier   +4 more
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