Results 31 to 40 of about 91,795 (159)

Intracellular Staining for Phosphorylated STAT4 and STAT5 in Mouse Splenocytes

Bio-Protocol, 2014
The Stat (Signal Transducer and Activator of Transcription) family of proteins are critical signal transducers involved in fundamental cellular processes, including cell growth and differentiation, development, apoptosis, immune responses and ...
Ana Villegas-Mendez, J. de Souza, Seen-Wai Lavelle, Emily Findlay, Tovah Shaw, Christiaan Saris, Christopher Hunter, Eleanor Riley , Kevin Couper   +8 more
doaj   +1 more source

EPHA2, a promising therapeutic target for hepatocellular carcinoma

Molecular & Cellular Oncology, 2021
Identifying critical drivers of oncogenesis and tumor progression is essential for developing effective hepatocellular carcinoma (HCC) therapeutics. Our recent findings has demonstrated that targeting Ephrin Receptor A2 (EPHA2) suppresses HCC initiation ...
Hao Wang, Wei Qiu
doaj   +1 more source

The crosstalk between STAT3 and microRNA in cardiac diseases and protection

Frontiers in Cardiovascular Medicine, 2022
Signal transducer and activator of transcription 3 (STAT3), an important transcription factor and signaling molecule, play an important role in cardiac disease and protection. As a transcription factor, STAT3 upregulates anti-oxidative and anti-apoptotic
Lan Wu, Lan Wu, Zhizheng Li, Yanfei Li, Yanfei Li   +4 more
doaj   +1 more source

Interplay between Janus Kinase/Signal Transducer and Activator of Transcription Signaling Activated by Type I Interferons and Viral Antagonism

Frontiers in Immunology, 2017
Interferons (IFNs), which were discovered a half century ago, are a group of secreted proteins that play key roles in innate immunity against viral infection.
Yuchen Nan, Yuchen Nan, Chunyan Wu, Yan-Jin Zhang   +3 more
doaj   +1 more source

Role of STAT3 in pancreatic cancer

Exploration of Targeted Anti-tumor Therapy
Pancreatic cancer remains a serious and deadly disease, impacting people globally. There remain prominent gaps in the current understanding of the disease, specifically regarding the role of the signal transducer and activator of transcription (STAT ...
Zachary Hamel, Sierra Sanchez, David Standing, Shrikant Anant   +3 more
doaj   +1 more source

Manassantin A and B From Saururus chinensis Inhibit Interleukin-6–Induced Signal Transducer and Activator of Transcription 3 Activation in Hep3B Cells

Journal of Pharmacological Sciences, 2011
Inhibition of interleukin-6 (IL-6) has been postulated to be an effective therapy in the pathogenesis of several inflammatory diseases. The current study was performed to examine potential effects of manassantin A and B isolated from Saururus chinensis ...
Jong Sun Chang, Seung Woong Lee, Myo Sun Kim, Bo Ra Yun, Mi Hye Park, Seok-Geun Lee, Su-Jin Park, Woo Song Lee, Mun-Chual Rho   +8 more
doaj   +1 more source

STAT5B (signal transducer and activator of transcription 5B) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012
Review on STAT5B (signal transducer and activator of transcription 5B), with data on DNA, on the protein encoded, and where the gene is implicated.
Del, Rosario AM, Bernaciak, TM, Silva, CM   +2 more
openaire   +2 more sources

Polymorphisms in signal transducer and activator of transcription 3 and lung function in asthma

Respiratory Research, 2005
Background Identifying genetic determinants for lung function is important in providing insight into the pathophysiology of asthma. Signal transducer and activator of transcription 3 is a transcription factor latent in the cytoplasm; the gene (STAT3) is ...
Lazarus Ross, Lake Stephen, Tantisira Kelan G, Litonjua Augusto A, Richter Brent G, Gabriel Stacey, Silverman Eric S, Weiss Scott T   +7 more
doaj   +1 more source

Signal transducer and activator of transcription (STAT) signalling and T‐cell lymphomas

Immunology, 2005
SummaryInteraction of cytokines with their cognate receptors leads to the activation of latent transcription factors – the signal transducers and activators of transcription (STAT) proteins – whose biological activities ultimately regulate many critical aspects of cell growth, survival and differentiation.
Mitchell, T J, John, S
openaire   +4 more sources

Targeting STAT6-mediated synovial macrophage activation improves pain in experimental knee osteoarthritis

Arthritis Research & Therapy
Background Pain from osteoarthritis (OA) is one of the top causes of disability worldwide, but effective treatment is lacking. Nociceptive factors are released by activated synovial macrophages in OA, but depletion of synovial macrophages paradoxically ...
Garth Blackler, Yue Lai-Zhao, Joseph Klapak, Holly T. Philpott, Kyle K. Pitchers, Andrew R. Maher, Benoit Fiset, Logan A. Walsh, Elizabeth R. Gillies, C. Thomas Appleton   +9 more
doaj   +1 more source