Results 1 to 10 of about 90,515 (133)

-escin mitigates neuroinflammation and apoptosis caused by ischemic stroke through the inhibition of the interleukin-6/Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway [PDF]

Journal of International Medical Research
Objective This study aimed to investigate the protective effects of β-escin against neuroinflammatory injury and its influence on the interleukin-6/Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway in a rat model of ...
Duan Yanqin, Liu Shenglan, Zhang Yu, Deng Yu, Du Qing, Zeng Hongliang, Tan Dianbo, Liu Chunhai, Yin yong, Liu Dongliang   +9 more
doaj   +2 more sources

Upregulation of signal transducer and activator of transcription 3 in dogs with chronic inflammatory enteropathies [PDF]

Journal of Veterinary Internal Medicine, 2021
Background In inflammatory bowel disease (IBD) in humans, phosphorylated signal transducer and activator of transcription 3 (pSTAT3) is upregulated in mucosal epithelial cells and correlates with clinical severity. Hypothesis/Objective To investigate the
Anita Manz, Karin Allenspach, Stefan Kummer, Barbara Richter, Ingrid Walter, Sabine Macho‐Maschler, Alexander Tichy, Iwan A Burgener, Nicole Luckschander‐Zeller   +8 more
doaj   +2 more sources

Signal Transducer and Activator of Transcription 3 Mutation with Invasive Eosinophilic Disease

Allergy & Rhinology, 2012
Hyper-IgE syndrome (HIES), or Jobs disease, is a rare immunologic disorder characterized by the triad of staphylococcal abscesses, pneumonia with pneumatocele formation, and elevated IgE. It has been shown to have multiple modes of inheritance, autosomal
Kara Crosby D.O., David Swender D.O., Leah Chernin D.O., Said Hafez-Khayyata, Hans Ochs M.D., Haig Tcheurekdjian M.D., Robert Hostoffer D.O.   +6 more
doaj   +3 more sources

Investigating the role of signal transducer and activator of transcription 3 in feline injection site sarcoma [PDF]

BMC Veterinary Research, 2022
Background Feline injection-site sarcomas (FISSs) are malignant mesenchymal tumors of different histotypes. The pathogenesis of FISS has been correlated with chronic inflammation, resulting in neoplastic transformation.
Cheng-Hsin Shih, Yen-Chen Chang, Yun-Chiang Lai, Hue-Ying Chiou   +3 more
doaj   +2 more sources

Signal Transducer and Activator of Transcription-3 Modulation of Cardiac Pathology in Chronic Chagasic Cardiomyopathy [PDF]

Frontiers in Cellular and Infection Microbiology, 2021
Chronic Chagasic cardiomyopathy (CCC) is a severe clinical manifestation that develops in 30%–40% of individuals chronically infected with the protozoal parasite Trypanosoma cruzi and is thus an important public health problem.
Kristyn A. Hoffman, Kristyn A. Hoffman, Maria Jose Villar, Maria Jose Villar, Cristina Poveda, Cristina Poveda, Maria Elena Bottazzi, Maria Elena Bottazzi, Maria Elena Bottazzi, Maria Elena Bottazzi, Peter J. Hotez, Peter J. Hotez, Peter J. Hotez, Peter J. Hotez, David J. Tweardy, Kathryn M. Jones, Kathryn M. Jones, Kathryn M. Jones   +17 more
doaj   +2 more sources

Ginsenoside Rd ameliorates muscle wasting by suppressing the signal transducer and activator of transcription 3 pathway [PDF]

Journal of Cachexia, Sarcopenia and Muscle, 2022
Background The effects of some drugs, aging, cancers, and other diseases can cause muscle wasting. Currently, there are no effective drugs for treating muscle wasting.
Yoseph Toni Wijaya, Tania Setiawan, Ita Novita Sari, Keunwan Park, Chan Hee Lee, Kae Won Cho, Yun Kyung Lee, Jae‐Young Lim, Jeong Kyo Yoon, Sae Hwan Lee, Hyog Young Kwon   +10 more
doaj   +2 more sources

Bilateral Superior Cervical Sympathectomy Activates Signal Transducer and Activator of Transcription 3 Signal to Alleviate Myocardial Ischemia-Reperfusion Injury [PDF]

Frontiers in Cardiovascular Medicine, 2022
BackgroundThere is growing evidence about the effect of bilateral superior cervical sympathectomy on myocardial ischemia-reperfusion (I/R) injury. Studies have increasingly found that the signal transducer and activator of transcription 3 (STAT3) plays a
Lixia Li, Jiahong Gao, Lin Gao, Le Li, Hongfei Zhang, Wei Zhao, Shiyuan Xu   +6 more
doaj   +2 more sources

Histone H1.2 promotes hepatocarcinogenesis by regulating signal transducer and activator of transcription 3 signaling. [PDF]

Cancer Sci, 2022
AbstractLinker histone H1.2 (H1.2), encoded by HIST1H1C (H1C), is a major H1 variant in somatic cells. Among five histone H1 somatic variants, upregulated H1.2 was found in human hepatocellular carcinoma (HCC) samples and in a diethylnitrosamine (DEN)‐induced HCC mouse model.
Wang Q, Chen Y, Xie Y, Yang D, Sun Y, Yuan Y, Chen H, Zhang Y, Huang K, Zheng L.   +9 more
europepmc   +3 more sources

Signal Transducer and Activator of Transcription 3 [PDF]

Current Opinion in Hematology, 2016
Signal transducer and activator of transcription 3 (STAT3) is an important transcription factor involved in a wide variety of cellular functions. Germline loss-of-function mutations are known to cause hyper-IgE immunodeficiency (autosomal dominant hyper IgE syndrome), whereas somatic gain-of-function mutations have been described in large granular cell
Lisa R, Forbes, Josh, Milner, Elie, Haddad   +2 more
openaire   +3 more sources

NT157 Inhibits HCC Migration via Downregulating the STAT3/Jab1 Signaling Pathway

Technology in Cancer Research & Treatment, 2021
Purpose: The high fatality-to-case ratio of hepatocellular carcinoma is directly related to metastasis. The signal transducer and activator of transcription-3 is a key mediator of the cytokine and growth factor signaling pathways and drives the ...
SiZhe Yu, Yu Wang, KeJia Lv, Jia Hou, WenYuan Li, Xiao Wang, Hui Guo, WenJuan Wang   +7 more
doaj   +1 more source