Results 11 to 20 of about 90,535 (152)

Diminution of signal transducer and activator of transcription 3 signaling inhibits vascular permeability and anaphylaxis [PDF]

Journal of Allergy and Clinical Immunology, 2016
During IgE-mediated immediate hypersensitivity reactions, vascular endothelial cells permeabilize in response to mast cell mediators. We have demonstrated previously that patients and mice with signal transducer and activator of transcription 3 (STAT3) mutations (autosomal dominant hyper-IgE syndrome [AD-HIES]) are partially protected from anaphylaxis ...
Valerie, Hox, Michael P, O'Connell, Jonathan J, Lyons, Paul, Sackstein, Thomas, Dimaggio, Nina, Jones, Celeste, Nelson, Manfred, Boehm, Steven M, Holland, Alexandra F, Freeman, David J, Tweardy, Ana, Olivera, Dean D, Metcalfe, Joshua D, Milner   +13 more
openaire   +4 more sources

S-Glutathionylation Impairs Signal Transducer and Activator of Transcription 3 Activation and Signaling [PDF]

Endocrinology, 2008
S-glutathionylation is a physiological, reversible protein modification of cysteine residues with glutathione in response to mild oxidative stress. Because the key cell growth regulator signal transducer and activator of transcription (STAT) 3 is particularly susceptible to redox regulation, we hypothesized that oxidative modification of cysteine ...
Yi, Xie, Sutapa, Kole, Patricia, Precht, Michael J, Pazin, Michel, Bernier   +4 more
openaire   +2 more sources

Clinicopathological significance of protein disulphide isomerase A3 and phosphorylated signal transducer and activator of transcription 3 in cervical carcinoma [PDF]

Contemporary Oncology
Asmaa Abdullatif, Aziza E. Abdelrahman, Adel Bakry, Shimaa A. Gharieb, Mohamed Sh. Ramadan, Mohamed A. Wasfy, Abdelfatah H. Abdelwanis, Enas M. Fouad   +7 more
doaj   +2 more sources

Activated Signal Transducer and Activator of Transcription (STAT) 3 [PDF]

Cancer Research, 2004
Abstract Constitutive activation of the Janus-activated kinase/signal transducer and activator of transcription (STAT) pathway promotes the proliferation and survival of cancer cells in culture and is associated with various cancers, including those of the ovary.
Debra L. Silver, Honami Naora, Jinsong Liu, Wenjun Cheng, Denise J. Montell   +4 more
openaire   +1 more source

Special Issue “Role of STAT3 in Oncogenesis”

Biomedicines, 2022
This Biomedicines Special Issue was designed to attract articles that focused on the pleiotropic role of the signal transducer and activator of transcription 3 (STAT3) transcription factor in different facets of tumorigenesis [...]
Kwang Seok Ahn
doaj   +1 more source

The crosstalk between STAT3 and microRNA in cardiac diseases and protection

Frontiers in Cardiovascular Medicine, 2022
Signal transducer and activator of transcription 3 (STAT3), an important transcription factor and signaling molecule, play an important role in cardiac disease and protection. As a transcription factor, STAT3 upregulates anti-oxidative and anti-apoptotic
Lan Wu, Lan Wu, Zhizheng Li, Yanfei Li, Yanfei Li   +4 more
doaj   +1 more source

STAT3 gain-of-function mutation in a patient with pulmonary Mycobacterium abscessus infection

Respiratory Medicine Case Reports, 2020
Background: Signal transducer and activator of transcription 3 (STAT3) is a transcription factor involved in cellular proliferation, apoptosis, and differentiation.
Miguel S. Gonzalez-Mancera, Britt Johnson, Mehdi Mirsaeidi   +2 more
doaj   +1 more source

The relationship between microRNAs and the STAT3-related signaling pathway in cancer

Tumor Biology, 2017
MicroRNAs are non-coding RNAs that regulate gene expression by targeting messenger RNA molecules in 3′ untranslated region. Mounting evidence indicates that microRNAs regulate several factors to influence various biological activities that are related to
Lin Zhang, Junyao Li, Qi Wang, Guangping Meng, Xuejiao Lv, Hong Zhou, Wei Li, Jie Zhang   +7 more
doaj   +1 more source

Chemoreversal Agents from Taiwanofungus Genus and Their More Potent Methyl Derivatives Targeting Signal Transducer and Activator of Transcription 3 (STAT3) Phosphorylation

Pharmaceuticals, 2021
Multidrug resistance (MDR), for which the mechanisms are not yet fully clear, is one of the major obstacles to cancer treatment. In recent years, signal transducer and activator of transcription 3 (STAT3) were found to be one of the important MDR ...
Ko-Hua Yu, Chin-Chuan Hung, Tian-Shung Wu, Chin-Fu Chen, I-Ting Wu, Ping-Chung Kuo, Sio-Hong Lam, Hsin-Yi Hung   +7 more
doaj   +1 more source

Aberrant activation of signal transducer and activator of transcription-3 (STAT3) signaling in endometriosis [PDF]

Human Reproduction, 2015
Are STAT3 signaling molecules differentially expressed in endometriosis?
Byung Gak, Kim, Jung-Yoon, Yoo, Tae Hoon, Kim, Jung-Ho, Shin, John F, Langenheim, Susan D, Ferguson, Asgerally T, Fazleabas, Steven L, Young, Bruce A, Lessey, Jae-Wook, Jeong   +9 more
openaire   +2 more sources