Results 21 to 30 of about 90,535 (152)

Polymorphisms in signal transducer and activator of transcription 3 and lung function in asthma

Respiratory Research, 2005
Background Identifying genetic determinants for lung function is important in providing insight into the pathophysiology of asthma. Signal transducer and activator of transcription 3 is a transcription factor latent in the cytoplasm; the gene (STAT3) is ...
Lazarus Ross, Lake Stephen, Tantisira Kelan G, Litonjua Augusto A, Richter Brent G, Gabriel Stacey, Silverman Eric S, Weiss Scott T   +7 more
doaj   +1 more source

Kynurenine–PARP-1 Link Mediated by MicroRNA 210 May Be Dysregulated in Pulmonary Hypertension

Anatolian Journal of Cardiology, 2022
Background: Dysregulation of microRNAs is associated with pulmonary hypertension. The present study aimed to determine the alterations in microRNA and microRNA expressions and their role in signaling pathways and investigate the relationship with serum ...
Alperen Emre Akgun, Yalın Tolga Yaylalı, Mücahit Seçme, Yavuz Dodurga, Hande Şenol   +4 more
doaj   +1 more source

Indole-3-carbinol induces apoptosis of chronic myelogenous leukemia cells through suppression of STAT5 and Akt signaling pathways

Tumor Biology, 2017
Signal transducer and activator of transcription 5 and Akt pathways, implicated in signaling transduction downstream of BCR–ABL, play critical roles in the pathogenesis of chronic myeloid leukemia.
Majid Safa, Leila Jafari, Fatemeh Alikarami, Rima Manafi Shabestari, Ahmad Kazemi   +4 more
doaj   +1 more source

The Role of Signal Transducer and Activator of Transcription 3 (STAT3) in Tumor Immunity

Indonesian Biomedical Journal, 2012
BACKGROUND: Inflammation is a key component of the tumor microenvironment. Cancer-associated inflammation is marked by the presence of specific inflammatory cells and inflammatory mediators.
Oeij Anindita Adhika, M Nurhalim Shahib
doaj   +1 more source

Anti-Interferon-γ Autoantibodies Impair T-Lymphocyte Responses in Patients with Talaromyces marneffei Infections

Infection and Drug Resistance, 2022
Zhao-Ming Chen,1,* Xiao-Yun Yang,1,2,* Zheng-Tu Li,1,* Wei-Jie Guan,1,3 Ye Qiu,4 Shao-Qiang Li,1 Yang-Qing Zhan,1 Zi-Ying Lei,5 Jing Liu,4 Jian-Quan Zhang,6 Zhong-Fang Wang,1,2 Feng Ye1 1State Key Laboratory of Respiratory Disease, National ...
Chen ZM, Yang XY, Li ZT, Guan WJ, Qiu Y, Li SQ, Zhan YQ, Lei ZY, Liu J, Zhang JQ, Wang ZF, Ye F   +11 more
doaj  

Kinome and Transcriptome Profiling Reveal Broad and Distinct Activities of Erlotinib, Sunitinib, and Sorafenib in the Mouse Heart and Suggest Cardiotoxicity From Combined Signal Transducer and Activator of Transcription and Epidermal Growth Factor Receptor Inhibition

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundMost novel cancer therapeutics target kinases that are essential to tumor survival. Some of these kinase inhibitors are associated with cardiotoxicity, whereas others appear to be cardiosafe.
Timothy J. Stuhlmiller, Jon S. Zawistowski, Xin Chen, Noah Sciaky, Steven P. Angus, Sean T. Hicks, Traci L. Parry, Wei Huang, Ju Youn Beak, Monte S. Willis, Gary L. Johnson, Brian C. Jensen   +11 more
doaj   +1 more source

Signal Transducer and Activator of Transcription 3 Control of Human T and B Cell Responses

Frontiers in Immunology, 2018
Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that is activated downstream of many key cytokine receptors expressed by lymphocytes.
Elissa K. Deenick, Elissa K. Deenick, Simon J. Pelham, Simon J. Pelham, Alisa Kane, Alisa Kane, Alisa Kane, Alisa Kane, Cindy S. Ma, Cindy S. Ma   +9 more
doaj   +1 more source

Signal transducer and activator of transcription 3 (STAT3) promoter methylation and expression in pituitary adenoma

BMC Medical Genetics, 2017
Background Pituitary adenoma (PA) is a benign brain tumor that can cause neurological, endocrinological and ophthalmological aberrations. Till now there is a need to identify factors that can influence the tumor invasiveness and recurrence.
Indre Valiulyte, Giedrius Steponaitis, Daina Skiriute, Arimantas Tamasauskas, Paulina Vaitkiene   +4 more
doaj   +1 more source

Flurbiprofen ameliorates glucose deprivation-induced leptin resistance

Frontiers in Pharmacology, 2016
Leptin resistance is one of the mechanisms involved in the pathophysiology of obesity. The present study showed that glucose deprivation inhibited leptin-induced phosphorylation of signal transducer and activator of transcription 3 (STAT3) and signal ...
Toru Hosoi, Yuka Suyama, Takaaki Kayano, Koichiro Ozawa   +3 more
doaj   +1 more source

Signal transducer and activator of transcription-3 induces microRNA-155 expression in chronic lymphocytic leukemia. [PDF]

PLoS ONE, 2013
MicroRNA (miR) abnormalities play a key role in the pathogenesis of chronic lymphocytic leukemia (CLL). High levels of miR-155 have been detected in human neoplasms, and overexpression of miR-155 has been found to induce lymphoma in mice.
Ping Li, Srdana Grgurevic, Zhiming Liu, David Harris, Uri Rozovski, George A Calin, Michael J Keating, Zeev Estrov   +7 more
doaj   +1 more source