Results 41 to 50 of about 90,535 (152)

miR-519a enhances chemosensitivity and promotes autophagy in glioblastoma by targeting STAT3/Bcl2 signaling pathway

Journal of Hematology & Oncology, 2018
Background Chemoresistance to temozolomide (TMZ) is a major challenge in the treatment of glioblastoma (GBM). We previously found that miR-519a functions as a tumor suppressor in glioma by targeting the signal transducer and activator of transcription 3 (
Hong Li, Lei Chen, Jun-jie Li, Qiang Zhou, Annie Huang, Wei-wen Liu, Ke Wang, Liang Gao, Song-tao Qi, Yun-tao Lu   +9 more
doaj   +1 more source

Signal transducers and activators of transcription 3 function in lung cancer

Journal of Cancer Research and Therapeutics, 2013
Constitutively activation of signal transducers and activators of transcription 3 (STAT3) proteins are involved in multiple aberrant signaling pathway-oncogenic pathways, including pathways regulating tumor cell survival. STAT3 is one of the second messengers in the Janus activated family kinases/STAT signaling pathway and is regulated by many ...
Chun-Jie, Li, Yue-Chuan, Li, Dong-Rui, Zhang, Jian-Hui, Pan   +3 more
openaire   +2 more sources

Data from Activated Signal Transducer and Activator of Transcription (STAT) 3

, 2023
<div>Abstract<p>Constitutive activation of the Janus-activated kinase/signal transducer and activator of transcription (STAT) pathway promotes the proliferation and survival of cancer cells in culture and is associated with various cancers, including those of the ovary.
Denise J. Montell, Wenjun Cheng, Jinsong Liu, Honami Naora, Debra L. Silver   +4 more
openaire   +1 more source

SD-1029 Inhibits Signal Transducer and Activator of Transcription 3 Nuclear Translocation [PDF]

Clinical Cancer Research, 2006
Abstract Purpose: Signal transducer and activator of transcription 3 (Stat3) proteins have important roles in cancer cell survival and proliferation. Recent studies show that aberrant Stat3 activation promotes tumor growth and survival in several human cancers, and thus, presents an attractive pathway for the development of targeted ...
Zhenfeng, Duan, James E, Bradner, Edward, Greenberg, Ross, Levine, Rosemary, Foster, Jennifer, Mahoney, Michael V, Seiden   +6 more
openaire   +2 more sources

Manassantin A and B From Saururus chinensis Inhibit Interleukin-6–Induced Signal Transducer and Activator of Transcription 3 Activation in Hep3B Cells

Journal of Pharmacological Sciences, 2011
Inhibition of interleukin-6 (IL-6) has been postulated to be an effective therapy in the pathogenesis of several inflammatory diseases. The current study was performed to examine potential effects of manassantin A and B isolated from Saururus chinensis ...
Jong Sun Chang, Seung Woong Lee, Myo Sun Kim, Bo Ra Yun, Mi Hye Park, Seok-Geun Lee, Su-Jin Park, Woo Song Lee, Mun-Chual Rho   +8 more
doaj   +1 more source

Signal Transducer and Activator of Transcription 3 (STAT3) Suppresses STAT1/Interferon Signaling Pathway and Inflammation in Senescent Preadipocytes

Antioxidants, 2021
Obesity promotes premature aging and dysfunction of white adipose tissue (WAT) through the accumulation of cellular senescence. The senescent cells burden in WAT has been linked to inflammation, insulin-resistance (IR), and type 2 diabetes (T2D).
Aisha Y. Madani, Yasser Majeed, Houari B. Abdesselem, Maha V. Agha, Muneera Vakayil, Nour K. Al Sukhun, Najeeb M. Halabi, Pankaj Kumar, Shahina Hayat, Mohamed A. Elrayess, Arash Rafii, Karsten Suhre, Nayef A. Mazloum   +12 more
doaj   +1 more source

Cross‐talk between signal transducer and activator of transcription 3 and estrogen receptor signaling

FEBS Letters, 2000
Interleukin‐6 (IL‐6) is a multifunctional cytokine that plays important roles in the immune system, hematopoiesis, and acute phase reactions. Estrogens have significant roles in a variety of biological events, such as the development and maintenance of female reproductive organs, and bone and lipid metabolism.
Yamamoto, Tetsuya, Matsuda, Tadashi, Junicho, Akira, Kishi, Hiroyuki, Saatcioglu, Fahri, Muraguchi, Atsushi   +5 more
openaire   +2 more sources

Diosmetin inhibits cell proliferation and promotes apoptosis through STAT3/c-Myc signaling pathway in human osteosarcoma cells

Biological Research, 2021
Background Diosmetin is a bioflavonoid compound naturally abundant in citrus fruits. It is found to perform a variety of activities, while its antitumor property in osteosarcoma, a malignant tumor with unmet clinical treatment, remained unknown.
Rende Ning, Guang Chen, Run Fang, Yanhui Zhang, Wenjuan Zhao, Feng Qian   +5 more
doaj   +1 more source

Size-Dependent Biological Effects of Quercetin Nanocrystals

Molecules, 2019
Quercetin (QE) is an attractive natural compound for cancer prevention due to its beneficial anti-oxidative and anti-proliferative effects. However, QE is poorly soluble in water and slightly soluble in oil, which results in its low oral bioavailability ...
Qian Liu, Xi Yang, Jianxu Sun, Fanglin Yu, Hui Zhang, Jing Gao, Aiping Zheng   +6 more
doaj   +1 more source

Leptin promotes human glioblastoma growth through activating Signal Transducers and Activators of Transcription 3 signaling

Brain Research Bulletin, 2012
Leptin plays an important role in cancer development and progression. However, its role on human glioblastoma cell line U87 growth and the underlying mechanism remains unexplored. In this study, we assessed the effect of leptin on U87 cells proliferation in vitro and in vivo, elucidating its underlying mechanism.
Guosheng, Han, Laixing, Wang, Rui, Zhao, Zhijian, Yue, Xiaoping, Zhou, Xiaowu, Hu, Yiqun, Cao, Dongwei, Dai, Jianmin, Liu   +8 more
openaire   +2 more sources