Results 51 to 60 of about 8,133 (173)

Corticosteroids for the common cold [PDF]

, 2015
BACKGROUND: The common cold is a frequent illness, which, although benign and self limiting, results in many consultations to primary care and considerable loss of school or work days. Current symptomatic treatments have limited benefit.
Del Mar, Chris B., Glasziou, Paul P., Hayward, Gail, Heneghan, Carl J., Perera, Rafael, Thompson, Matthew J.   +5 more
core   +1 more source

HSV-2 Infection of Human Genital Epithelial Cells Upregulates TLR9 Expression Through the SP1/JNK Signaling Pathway [PDF]

, 2020
It is known that herpes simplex virus type 2 (HSV-2) triggers the activation of Toll-like receptor (TLR) 9 signaling pathway and the consequent production of antiviral cytokines in dendritic cells.
Barreto, M, Chowdhury, T, Fu, M, Guan, X, Hu, K, Hu, Q, Li, M, Luo, S, Singh, R, Wang, J, Xiao, J, Zhang, M   +11 more
core   +1 more source

Metagenomic analysis of DNA viruses from posttransplant lymphoproliferative disorders

Cancer Medicine, Volume 8, Issue 3, Page 1013-1023, March 2019., 2019
We sequenced viral DNA from paraffin‐embedded tissues of PTLD and associated to clinical severity and outcomes. Certain EBV genes had higher proportions of nonsynonymous variants. Anellovirus tissue positivity associated with earlier patient death. Abstract Posttransplant lymphoproliferative disorders (PTLDs), 50%‐80% of which are strongly associated ...
Vikas R. Dharnidharka, Marianna B. Ruzinova, Chun‐Cheng Chen, Priyanka Parameswaran, Harry O'Gorman, Charles W. Goss, Hongjie Gu, Gregory A. Storch, Kristine Wylie   +8 more
wiley   +1 more source

Volatile Acid‐Solvent Evaporation (VASE): Molecularly Homogeneous Distribution of Acyclovir in a Bioerodable Polymer Matrix for Long‐Term Treatment of Herpes Simplex Virus‐1 Infections

Journal of Drug Delivery, Volume 2018, Issue 1, 2018., 2018
Treatment for herpes simplex virus‐1 and ‐2 (HSV‐1 and ‐2) patients who suffer from recurrent outbreaks consists of multiple daily doses of the antiviral drugs acyclovir (ACV), penciclovir, or their more orally bioavailable derivatives valacyclovir or famciclovir.
James R. Stegman, Jill K. Badin, Kaitlyn A. Biles, Thamar Etienne, Sogand Fartash-Naini, Ariel D. Gordon, Zachary W. Greeley, Benjamin W. Harding, Ricardo J. Mack, Danielle Masica, Ashley N. Nelson, Amandeep K. Samra, Sarah E. Smith, Gabrielle P. Thomas, Haley J. Zack, Timothy J. Brunker, Barry J. Margulies, Carla Caramella   +17 more
wiley   +1 more source

The landscape of viral associations in human cancers [PDF]

, 2020
Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, for which whole-genome and—for a subset—whole-transcriptome sequencing data from 2,658 cancers across 38 tumor types was aggregated, we systematically investigated potential ...
Alawi, Malik, Borozan, Ivan, Brewer, Daniel S, Cooper, Colin S, Desai, Nikita, Eils, Roland, Ferretti, Vincent, Grundhoff, Adam, Iskar, Murat, Lichter, Peter, Moch, Holger, PCAWG Consortium, PCAWG Pathogens, Sültmann, Holger, Zapatka, Marc   +14 more
core   +3 more sources

HIV‐1 Replication in HIV‐Infected Individuals Is Significantly Reduced When Peripheral Blood Mononuclear Cells Are Superinfected with HSV‐1

The Scientific World Journal, Volume 2012, Issue 1, 2012., 2012
Herpes simplex virus (HSV) can cause generalized infection in human immunodeficiency virus‐ (HIV‐) infected patients leading to death. This study investigated HSV‐1 replication in PBMCs from 25 HIV‐infected individuals and 15 healthy donors and the effects of HSV‐1 superinfection on HIV‐1 production.
Taneth Yamsuwan, Chintana Chirathaworn, Pokrath Hansasuta, Parvapan Bhattarakosol, K. Ikuta, N. Maneekarn, A. Zakhartchouk   +6 more
wiley   +1 more source

Regulated expression of galectin-1 after in vitro productive infection with herpes simplex virus type 1: implications for T cell apoptosis [PDF]

, 2005
Apoptosis of cytotoxic T lymphocytes by herpes simplex virus type-1 (HSV-1) has been reported to be a relevant mechanism of viral immune evasion. Galectin-1 (Gal-1), an endogenous lectin involved in T-cell apoptosis, has recently gained considerable ...
Gonzalez, Maria Ines, Ilarregui, Juan Martin, Rabinovich, Gabriel Adrián, Rubinstein, Natalia, Sanjuan, Norberto Aníbal, Toscano, Marta Alicia   +5 more
core   +1 more source

Viral Infection in Renal Transplant Recipients

The Scientific World Journal, Volume 2012, Issue 1, 2012., 2012
Viruses are among the most common causes of opportunistic infection after transplantation. The risk for viral infection is a function of the specific virus encountered, the intensity of immune suppression used to prevent graft rejection, and other host factors governing susceptibility.
Jovana Cukuranovic, Sladjana Ugrenovic, Ivan Jovanovic, Milan Visnjic, Vladisav Stefanovic, Stephane Basmaciogullari, Balazs Harrach, Karen Mansfield   +7 more
wiley   +1 more source

Vaginal Microbicides: Detecting Toxicities in Vivo that Paradoxically Increase Pathogen Transmission [PDF]

, 2006
BACKGROUND: Microbicides must protect against STD pathogens without causing unacceptable toxic effects. Microbicides based on nonoxynol-9 (N9) and other detergents disrupt sperm, HSV and HIV membranes, and these agents are effective contraceptives.
Abusuwwa, Raed, Anderson, Deborah J., Cone, Richard A., Hoen, Timothy, Moench, Thomas R., Wong, XiXi   +5 more
core   +3 more sources

Excoecarianin, Isolated from Phyllanthus urinaria Linnea, Inhibits Herpes Simplex Virus Type 2 Infection through Inactivation of Viral Particles

Evidence-Based Complementary and Alternative Medicine, Volume 2011, Issue 1, 2011., 2011
Phyllanthus urinaria Linnea (Euphorbiaceae) is one of the traditional medicinal plants widely used by oriental people to treat various diseases. We have previously demonstrated that the acetone extract of P. urinaria inhibits herpes simplex virus type 2 (HSV‐2) but not HSV‐1 infection.
Hua-Yew Cheng, Chien-Min Yang, Ta-Chen Lin, Liang-Tzung Lin, Lien-Chai Chiang, Chun-Ching Lin   +5 more
wiley   +1 more source