HIV Integrase Inhibitors Block Replication of Alpha-, Beta-, and Gammaherpesviruses [PDF]
, 2014 The catalytic site of the HIV integrase is contained within an RNase H-like fold, and numerous drugs have been developed that bind to this site and inhibit its activity.
Angelova, Magdalena +8 more
core +2 more sources
Вопросы вирусологииHerpes simplex virus type 1 (HSV-1), newly named as Simplexvirus humanalpha1 is one of the most common pathogens in the human population, which can cause severe disease, often with fatal outcomes.
Natalia A. Demidova +3 more
doaj +1 more source
Enhanced Nigrostriatal Neuron-specific, Long-term Expression by Using Neural-specific Promoters in Combination with Targeted Gene Transfer by Modified Helper Virus-free HSV-1 Vector Particles [PDF]
, 2012 Background: Direct gene transfer into neurons has potential for developing gene therapy treatments for specific neurological conditions, and for elucidating neuronal physiology.
Cao, Haiyan +4 more
core +1 more source
The role of the neuronal microenvironment in sensory function and pain pathophysiology
Journal of Neurochemistry, Volume 168, Issue 11, Page 3620-3643, November 2024.In this review, we highlight the complex dynamic interactions between sensory neurons and non‐neuronal cells, including immune cells, neuronal accessory cells, adipocytes, and keratinocytes with a focus on skin, neuronal axons, dorsal root ganglia, and spinal cord.
Hana Starobova +3 more
wiley +1 more source
Changes in subcellular localization reveal interactions between human cytomegalovirus terminase subunits [PDF]
, 2012 BACKGROUND: During herpesvirus replication, terminase packages viral DNA into capsids. The subunits of herpes simplex virus terminase, UL15, UL28, and UL33, assemble in the cytoplasm prior to nuclear import of the complex.
McVoy, Michael A. +3 more
core +2 more sources
Rapid taxonomic categorization of short, abundant virus sequences for ecological analyses
Ecology and Evolution, Volume 14, Issue 6, June 2024.We sampled 1086 bats from two, adjacent Puerto Rican caves and tested them for infection by herpesviruses, resulting in 3131 short, viral sequences. Using percent identity of nucleotides and a machine learning algorithm (affinity propagation), we categorized herpesviruses into 43 operational taxonomic units (OTUs).
Anna R. Sjodin +3 more
wiley +1 more source
A Herpes Simplex Virus 2 (HSV-2) Glycoprotein D-expressing Nonreplicating Dominant-Negative HSV-2 Virus Vaccine Is Superior to a gD2 Subunit Vaccine against HSV-2 Genital Infection in Guinea Pigs [PDF]
, 2014 We recently constructed a novel non-replicating dominant-negative HSV-2 recombinant viral vaccine (CJ2-gD2) capable of expressing various HSV-2 antigens that are dominant targets of HSV-2-specific CD8 T-cell response.
Balliet, John W. +4 more
core +2 more sources
Biotechnology Progress, Volume 40, Issue 1, January/February 2024.Abstract The capacity to remove viruses by Planova filters produced by Asahi Kasei, primarily by small virus‐retentive filters, were compiled from data in peer‐reviewed publications and, partly, publicly available data from presentations at conferences (Planova workshops).
Albrecht Gröner
wiley +1 more source
Control of HSV-1 latency in human trigeminal ganglia—current overview [PDF]
, 2018 Although recurrent Herpes simplex virus type 1 (HSV-1) infections are quite common in humans, little is known about the exact molecular mechanisms involved in latency and reactivation of the virus from its stronghold, the trigeminal ganglion.
Derfuss, Tobias, Held, Kathrin
core
Rapid Evolution of BRCA1 and BRCA2 in Humans and Other Primates [PDF]
, 2014 The maintenance of chromosomal integrity is an essential task of every living organism and cellular repair mechanisms exist to guard against insults to DNA.
Demogines, Ann M. +6 more
core +3 more sources