Results 1 to 10 of about 985,952 (168)
Characterizing Stroke Clots Using Single‐Cell Sequencing [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseBackground Ischemic stroke results in significant morbidity and mortality. By examining gene expression of cells comprising stroke clots, we aim to gain valuable insights into the underlying mechanisms of this disease and identify potential biomarkers of
Daniela Renedo +17 more
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Single cell genome sequencing [PDF]
Current Opinion in Biotechnology, 2012 Whole genome amplification and next-generation sequencing of single cells have become a powerful approach for studying uncultivated microorganisms that represent 90-99% of all environmental microbes. Single cell sequencing enables not only the identification of microbes but also linking of functions to species, a feat not achievable by metagenomic ...
Suzan, Yilmaz, Anup K, Singh
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Clinical and Translational Discovery, 2022 Single‐cell sequencing has scientific impacts on better understanding immunity. There is rapid development in single cell‐based databases and analytic tools to provide the potential for clinical and translational discovery.
Dongsheng Chen +2 more
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Clinical and Translational Medicine, 2023 Single‐cell sequencing has scientific impacts on better understanding the immunity. There is a rapid development in single cell‐based databases and analytic tools to provide the potential of clinical and translational discovery.
Dongsheng Chen +2 more
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Single-cell sequencing in hematology
Current Opinion in Oncology, 2020 Purpose of review In this review, we highlight key recent insights into hematopoiesis and hematological malignancies through the application of novel single-cell approaches. We particularly focus on biological insights made through the study of stem/progenitors cells in myeloid malignancy at single-cell resolution.
Brierley, CK, Mead, AJ
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Single-cell ATAC sequencing analysis: From data preprocessing to hypothesis generation
Computational and Structural Biotechnology Journal, 2020 Most genetic variations associated with human complex traits are located in non-coding genomic regions. Therefore, understanding the genotype-to-phenotype axis requires a comprehensive catalog of functional non-coding genomic elements, most of which are ...
Seungbyn Baek, Insuk Lee
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Molecular Neurodegeneration, 2022 Alzheimer’s disease (AD) is the most common form of dementia, characterized by progressive cognitive impairment and neurodegeneration. Extensive clinical and genomic studies have revealed biomarkers, risk factors, pathways, and targets of AD in the past ...
Minghui Wang +11 more
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Single‐cell RNA‐sequencing of the brain [PDF]
Clinical and Translational Medicine, 2017 AbstractSingle‐cell RNA‐sequencing (scRNA‐seq) is revolutionizing our understanding of the genomic, transcriptomic and epigenomic landscapes of cells within organs. The mammalian brain is composed of a complex network of millions to billions of diverse cells with either highly specialized functions or support functions. With scRNA‐seq it is possible to
Raquel Cuevas-Diaz Duran +2 more
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scDA: Single cell discriminant analysis for single-cell RNA sequencing data
Computational and Structural Biotechnology Journal, 2021 Single-cell RNA-sequencing (scRNA-seq) techniques provide unprecedented opportunities to investigate phenotypic and molecular heterogeneity in complex biological systems.
Qianqian Shi +4 more
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Transcriptomics and single‐cell RNA‐sequencing [PDF]
Respirology, 2018 ABSTRACTThe past four decades have yielded advances in molecular biology allowing detailed characterization of the cellular genome and the transcriptome: the complete set of RNA species transcribed by a cell or tissue. Through transcriptomics and next‐generation sequencing, we can now attain an unprecedented level of detail in understanding cellular ...
Daniel C. Chambers +3 more
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