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The Impact of Heterogeneity on Single-Cell Sequencing [PDF]
Frontiers in Genetics, 2019 The importance of diversity and cellular specialization is clear for many reasons, from population-level diversification, to improved resiliency to unforeseen stresses, to unique functions within metazoan organisms during development and differentiation.
Samantha L. Goldman +13 more
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Methods, Challenges and Potentials of Single Cell RNA-seq [PDF]
, 2012 RNA-sequencing (RNA-seq) has become the tool of choice for transcriptomics. Several recent studies demonstrate its successful adaption to single cell analysis. This allows new biological insights into cell differentiation, cell-to-cell variation and gene
Daniel Hebenstreit, Hebenstreit, Daniel
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Single-cell sequencing of shrimp
, 2022 single-cell sequencing in ...
Yundong Li (8880365)
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single-cell sequencing data.rar
, 2022 This is the single cell sequencing of 114 cells.
Yisheng Liu (11992361)
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Recent advances in deciphering hippocampus complexity using single-cell transcriptomics
Neurobiology of Disease, 2023 Single-cell and single-nucleus RNA sequencing (scRNA-seq and snRNA-seq) technologies have emerged as revolutionary and powerful tools, which have helped in achieving significant progress in biomedical research over the last decade.
Chenxu Chang, Hongyan Zuo, Yang Li
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Single-Cell Semiconductor Sequencing [PDF]
, 2013 RNA-seq or transcriptome analysis of individual cells and small-cell populations is essential for virtually any biomedical field. It is especially critical for developmental, aging, and cancer biology as well as neuroscience where the enormous heterogeneity of cells present a significant methodological and conceptual challenge.
Andrea B, Kohn +4 more
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Single-cell RNA sequencing reveals T helper cells synthesizing steroids de novo to contribute to immune homeostasis [PDF]
, 2014 T helper 2 (Th2) cells regulate helminth infections, allergic disorders, tumor immunity, and pregnancy by secreting various cytokines. It is likely that there are undiscovered Th2 signaling molecules.
Xiuwei Zhang +32 more
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Microglia Heterogeneity in Alzheimer’s Disease: Insights From Single-Cell Technologies
Frontiers in Synaptic Neuroscience, 2021 Microglia are resident immune cells in the central nervous system and play critical roles in brain immunity, development, and homeostasis. The pathology of Alzheimer’s disease (AD) triggers activation of microglia.
Hansen Wang
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Single-Cell Sequencing in Neurodegenerative Disorders
Molecular Diagnosis & Therapy, 2023 Neurodegenerative disorders are typically characterized by late onset progressive damage to specific (sub)populations of cells of the nervous system that are essential for mobility, coordination, strength, sensation, and cognition. Addressing this selective cellular vulnerability has become feasible with the emergence of single-cell-omics technologies,
Jelena Pozojevic, Malte Spielmann
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Frontiers in Immunology, 2022 Single-cell omics is the profiling of individual cells through sequencing and other technologies including high-throughput analysis for single-cell resolution, cell classification, and identification as well as time series analyses.
Jinhua He +11 more
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