Results 11 to 20 of about 1,166,241 (315)
Journal of Inflammation ResearchXinru Hu,1,* Shuang Du,1,* Meng Chen,1 Hao Yang,1 Jia He,1 Lei Zhang,1 Bowen Tan,1 Tao Wu,2 Xi Duan1 1Department of Dermatovenereology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, People’s Republic of China ...
Hu X +8 more
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Journal of Inflammation ResearchJianan Liu,1 Li Wang,2 Weijun Zhong,1 Jing Cai,3 Yan Sun,3 SongJun Li,2 Jiayi Li,4 Yanhui Liu,2 Fu Xiong1,5,6 1Department of Medical Genetics/Experimental Education/Administration Center, School of Basic Medical Sciences, Southern Medical University ...
Liu J +8 more
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, 2021 Cells are the most fundamental building block of all living organisms. The investigation of any type of disease mechanism and its progression still remains challenging due to cellular heterogeneity characteristics and physiological state of cells in a ...
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Measuring single cell divisions in human tissues from multi-region sequencing data [PDF]
, 2020 Both normal tissue development and cancer growth are driven by a branching process of cell division and mutation accumulation that leads to intra-tissue genetic heterogeneity. However, quantifying somatic evolution in humans remains challenging. Here, we
Tomlinson, I. +14 more
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Applications of Single-Cell DNA Sequencing [PDF]
Annual Review of Genomics and Human Genetics, 2021 Over the past decade, genomic analyses of single cells—the fundamental units of life—have become possible. Single-cell DNA sequencing has shed light on biological questions that were previously inaccessible across diverse fields of research, including somatic mutagenesis, organismal development, genome function, and microbiology.
Evrony, Gilad D +2 more
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Purkinje Cell Patterning—Insights from Single-Cell Sequencing
Cells, 2022 Despite their homogeneous appearance, Purkinje cells are remarkably diverse with respect to their molecular phenotypes, physiological properties, afferent and efferent connectivity, as well as their vulnerability to insults.
Elizabeth J. Apsley, Esther B. E. Becker
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Single‐cell RNA sequencing in cancer research
Journal of Experimental & Clinical Cancer Research, 2021 Single-cell RNA sequencing (scRNA-seq), a technology that analyzes transcriptomes of complex tissues at single-cell levels, can identify differential gene expression and epigenetic factors caused by mutations in unicellular genomes, as well as new cell ...
Yijie Zhang +18 more
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Visual Genomics Analysis Studio as a Tool to Analyze Multiomic Data
Frontiers in Genetics, 2021 Type B adverse drug reactions (ADRs) are iatrogenic immune-mediated syndromes with mechanistic etiologies that remain incompletely understood. Some of the most severe ADRs, including delayed drug hypersensitivity reactions, are T-cell mediated ...
Rebecca J. Hertzman +14 more
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Application of single-cell RNA sequencing technologies in aortic dilatation diseases [PDF]
Jichu yixue yu linchuang, 2022 Aortic dilation disease, represented by aortic dissection and aortic aneurysm, is the most dangerous disease in vascular surgery. The pathogenesis of this disease is not very clear.
ZHENG Kai, REN Hua-liang, ZHANG Wang-de, LI Chun-min
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Microfluidics applications for high-throughput single cell sequencing
Journal of Nanobiotechnology, 2021 The inherent heterogeneity of individual cells in cell populations plays significant roles in disease development and progression, which is critical for disease diagnosis and treatment.
Wen-min Zhou +10 more
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