Results 1 to 10 of about 763,123 (182)

Single domain antibody multimers confer protection against rabies infection. [PDF]

PLoS ONE, 2013
Post-exposure prophylactic (PEP) neutralizing antibodies against Rabies are the most effective way to prevent infection-related fatality. The outer envelope glycoprotein of the Rabies virus (RABV) is the most significant surface antigen for generating ...
Bhargavi M Boruah, Dawei Liu, Duan Ye, Tie-Jun Gu, Chun-Lai Jiang, Mingsheng Qu, Edward Wright, Wei Wang, Wen He, Changzhen Liu, Bin Gao   +10 more
doaj   +6 more sources

Multimeric single-domain antibody complexes protect against bunyavirus infections

eLife, 2020
The World Health Organization has included three bunyaviruses posing an increasing threat to human health on the Blueprint list of viruses likely to cause major epidemics and for which no, or insufficient countermeasures exist.
Paul J Wichgers Schreur, Sandra van de Water, Michiel Harmsen, Erick Bermúdez-Méndez, Dubravka Drabek, Frank Grosveld, Kerstin Wernike, Martin Beer, Andrea Aebischer, Olalekan Daramola, Sara Rodriguez Conde, Karen Brennan, Dorota Kozub, Maiken Søndergaard Kristiansen, Kieran K Mistry, Ziyan Deng, Jan Hellert, Pablo Guardado-Calvo, Félix A Rey, Lucien van Keulen, Jeroen Kortekaas   +20 more
doaj   +2 more sources

Single-domain antibody-based protein degrader for synucleinopathies [PDF]

Molecular Neurodegeneration
Synucleinopathies are a group of neurodegenerative diseases characterized by the accumulation of α-synuclein (α-syn) in the brain, leading to motor and neuropsychiatric symptoms.
Yixiang Jiang, Yan Lin, Amber M. Tetlow, Ruimin Pan, Changyi Ji, Xiang-Peng Kong, Erin E. Congdon, Einar M. Sigurdsson   +7 more
doaj   +2 more sources

Single domain antibodies as a powerful tool for high quality surface plasmon resonance studies.

PLoS ONE, 2015
Single domain antibodies are recombinantly expressed functional antibodies devoid of light chains. These binding elements are derived from heavy chain antibodies found in camelids and offer several distinctive properties for applications in biotechnology
Eduardo Antonio Della Pia, Karen L Martinez   +1 more
doaj   +3 more sources

Progress of Single-domain Antibodies in Molecular Imaging of Tumors

Zhongliu Fangzhi Yanjiu, 2019
A single-domain antibody (sdAb) is the variable region extracted from antibodies with only heavy chains found in camelid serum. Single-domain antibodies have the characteristics of easy expression, good solubility, great stability and weak immunogenicity.
ZHANG Meixin, LIU Teli, GUO Xiaoyi, XU Xiaoxia, ZHU Hua, YANG Zhi   +5 more
doaj   +2 more sources

Development of a Chicken Immunoglobulin Heavy Chain Variable Region (VH) Single-Domain Antibody (sdAb) Against Calsequestrin (CSQ) and Its Application [PDF]

Antibodies
Background/Objectives: Calsequestrin (CSQ) is a calcium-binding protein that is highly soluble and can serve as a solubility-enhancing fusion tag in recombinant protein expression.
Sun Lee, Seoryeong Park, Hyunji Yang, Geummi Cho, Seung Youn Lee, Donggeun Lee, Nara Tae, Dae Hee Kim, Junho Chung   +8 more
doaj   +2 more sources

A single-domain antibody library based on a stability-engineered human VH3 scaffold. [PDF]

Sci Rep
Lee NJ, Jung M, Yang HY, Shim H.
europepmc   +3 more sources

Single-Domain Antibody Theranostics on the Horizon. [PDF]

J Nucl Med, 2022
Wei W, Younis MH, Lan X, Liu J, Cai W.
europepmc   +3 more sources

Kinetic Characterisation of a Single Chain Antibody against the Hormone Abscisic Acid: Comparison with Its Parental Monoclonal [PDF]

, 2016
A single-chain Fv fragment antibody (scFv) specific for the plant hormone abscisic acid (ABA) has been expressed in the bacterium Escherichia coli as a fusion protein.
A Hayhurst, A Sadanandom, A Wörn, AM Jones, Andrew J. Thompson, Andrew Marsh, B Kazemier, D Missiakas, DG Myszka, DG Myszka, DM Hoover, Ellen R Goldman, George O. Badescu, GM Banowetz, J Messens, J Phillips, J Wigger, LLH Christensen, M Malmqvist, MK Walker-Simmons, O Artsaenko, O Artsaenko, P Jurado, P Martineau, PB Luppa, Q Li, R Mertens, R Raag, R Waadt, Richard M. Napier, S Shaki-Loewensteina, SA Quarrie, SA Quarrie, SM Kipriyanova, Timothy R. Smith, TR Smith, UL Jönsson, WFM Stöcklein, Y-W Li   +38 more
core   +18 more sources

Preparation and identification of a single domain antibody specific for adenovirus vectors and its application to the immunoaffinity purification of adenoviruses

AMB Express, 2022
Adenovirus belongs to the family of Adenoviridae. As a vaccine carrier, it has high safety and stimulates the body to produce cellular immunity and humoral immunity.
Yi Cheng, Yanxia Hao, Fuxiang Bao, Huimin Zhang, Yanlong Liu, Kexin Ao, Shan Fu, Qiyao Wu, Zhi Wang   +8 more
doaj   +1 more source