Results 11 to 20 of about 763,272 (322)
Biotechnological applications of recombinant single-domain antibody fragments [PDF]
Microbial Cell Factories, 2011 Background Single-domain antibody fragments possess structural features, such as a small dimension, an elevated stability, and the singularity of recognizing epitopes non-accessible for conventional antibodies that make them interesting for several ...
de Marco Ario
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Single-domain antibodies for biomedical applications [PDF]
Immunopharmacology and Immunotoxicology, 2015 Single-domain antibodies are the smallest antigen-binding units of antibodies, consisting either only of one variable domain or one engineered constant domain that solely facilitates target binding. This class of antibody derivatives comprises naturally occurring variable domains derived from camelids and sharks as well as engineered human variable or ...
Simon Krah +5 more
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Single domain antibodies in tissue engineering [PDF]
, 2014 The aim of this thesis is to demonstrate the potential of VHH in tissue engineering applications, with a focus on bone and cartilage tissue regeneration. After a general introduction to this thesis in chapter 1, the selection of VHH targeting growth factors is described in chapter 2.
Emilie Dooms Rodrigues
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Single-domain antibodies make a difference [PDF]
Science, 2021 A double hit with one antibody construct may avoid viral ...
Xavier, Saelens, Bert, Schepens
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Immunogenicity and humanization of single‐domain antibodies [PDF]
The FEBS Journal, 2021 Single‐domain antibodies (sdAbs), the autonomous variable domains of camelid and shark heavy‐chain antibodies, have many desirable properties as components of biologic drugs. However, their sequences may increase the risk of immunogenicity and antidrug antibody (ADA) development in humans, and thus, sdAbs are routinely humanized during development ...
Rossotti, Martin A. +3 more
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Novel single-domain antibodies against the EGFR domain III epitope exhibit the anti-tumor effect
Journal of Translational Medicine, 2020 Background Monoclonal antibodies (mAbs) have been used for cancer therapy. They are large and have some disadvantages limiting their use. Smaller antibody fragments are needed as their alternatives. A fully human single-domain antibody (sdAb) has a small
Tao Chen +3 more
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Therapeutic Phage Display-Derived Single-Domain Antibodies for Pandemic Preparedness
Antibodies, 2023 Driven by necessity, the COVID-19 pandemic caused by SARS-CoV-2 has accelerated the development and implementation of new vaccine platforms and other viral therapeutics. Among these is the therapeutic use of antibodies including single-domain antibodies,
Janet M. Daly +2 more
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Stabilization of a Broadly Neutralizing Anti-Chikungunya Virus Single Domain Antibody
Frontiers in Medicine, 2021 A single domain antibody (clone CC3) previously found to neutralize a vaccine strain of the chikungunya virus (PRNT50 = 2. 5 ng/mL) was found to be broadly neutralizing.
Jinny L. Liu +9 more
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Single Domain Antibody application in bacterial infection diagnosis and neutralization
Frontiers in Immunology, 2022 Increasing antibiotic resistance to bacterial infections causes a serious threat to human health. Efficient detection and treatment strategies are the keys to preventing and reducing bacterial infections. Due to the high affinity and antigen specificity,
Qian Qin +11 more
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Single domain antibody: Development and application in biotechnology and biopharma. [PDF]
Immunol RevSummaryHeavy‐chain antibodies (HCAbs) are a unique type of antibodies devoid of light chains, and comprised of two heavy chains‐only that recognize their cognate antigen by virtue of a single variable domain also referred to as VHH, single domain antibody (sdAb), or nanobody (Nb). These functional HCAbs, serendipitous discovered about three decades ago,
Yu T +4 more
europepmc +4 more sources