Results 41 to 50 of about 590,891 (162)
Nanobodies as Versatile Tools to Understand, Diagnose, Visualize and Treat Cancer
EBioMedicine, 2016 Since their discovery, nanobodies have been used extensively in the fields of research, diagnostics and therapy. These antigen binding fragments, originating from Camelid heavy-chain antibodies, possess unusual hallmarks in terms of (small) size ...
Isabel Van Audenhove, Jan Gettemans
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BMC Biotechnology, 2009 Background Classical bioconjugation strategies for generating antibody-functionalized nanoparticles are non-specific and typically result in heterogeneous compounds that can be compromised in activity.
Raats Jos MH +3 more
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Importance of Hypervariable Region 2 for Stability and Affinity of a Shark Single-Domain Antibody Specific for Ebola Virus Nucleoprotein. [PDF]
PLoS ONE, 2016 Single-domain antibodies derived from the unique New Antigen Receptor found in sharks have numerous potential applications, ranging from diagnostic reagents to therapeutics.
George P Anderson +7 more
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Bamboo Shark as a Small Animal Model for Single Domain Antibody Production
Frontiers in Bioengineering and Biotechnology, 2021 The development of shark single domain antibodies (sdAbs) is hindered by the high cost and tediousness of large-sized shark farming. Here, we demonstrated white-spotted bamboo sharks (Chiloscyllium plagiosum) being cultivated commercially as a promising ...
Likun Wei +24 more
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Intracellular Antibody Capture (IAC) Methods for Single Domain Antibodies
, 2012 Intracellular single domain antibodies are recombinant proteins, comprising one variable region domain fragment, that bind specifically to intracellular molecules and can interfere with their particular functions within various cellular compartments.
Tanaka, T, Rabbitts, T
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Single‐domain antibody fragments with high conformational stability [PDF]
Protein Science, 2002 AbstractA variety of techniques, including high‐pressure unfolding monitored by Fourier transform infrared spectroscopy, fluorescence, circular dichroism, and surface plasmon resonance spectroscopy, have been used to investigate the equilibrium folding properties of six single‐domain antigen binders derived from camelid heavy‐chain antibodies with ...
Dumoulin, Mireille +8 more
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Single domain Camelid antibody fragments for molecular imaging and therapy of cancer
Frontiers in Oncology, 2023 Despite innovations in cancer therapeutics, cancer remains associated with high mortality and is one of biggest health challenges worldwide. Therefore, developing precise cancer imaging and effective treatments is an unmet clinical need.
Shulin Li +4 more
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Camelid Single-Domain Antibodies: Historical Perspective and Future Outlook
Frontiers in Immunology, 2017 Tremendous effort has been expended over the past two and a half decades to understand many aspects of camelid heavy chain antibodies, from their biology, evolution, and immunogenetics to their potential applications in various fields of research and ...
Mehdi Arbabi-Ghahroudi +1 more
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Scientific Reports, 2022 Venezuelan equine encephalitis virus (VEEV) is a mosquito borne alphavirus which leads to high viremia in equines followed by lethal encephalitis and lateral spread to humans.
Jinny L. Liu +9 more
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International Journal of Nanomedicine, 2019 Taofeng Du,1,2,* Guang Zhu,1,2,* Xiaoping Wu,1,2 Junyang Fang,1,2 En-Min Zhou1,2 1Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling 712100, Shaanxi, People’s Republic of China ...
Du T, Zhu G, Wu X, Fang J, Zhou EM
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