Results 11 to 20 of about 478,505 (298)
Selection of single chain antibody fragments binding to the extracellular domain of 4-1BB receptor by phage display technology [PDF]
Tumor Biology, 2017 The 4-1BB is a surface glycoprotein that pertains to the tumor necrosis factor–receptor family. There is compelling evidence suggesting important roles for 4-1BB in the immune response, including cell activation and proliferation and also cytokine ...
Salman Bagheri +8 more
doaj +3 more sources
Effect of single-chain antibody targeting of the ligand-binding domain in the anaplastic lymphoma kinase receptor [PDF]
Oncogene, 2009 The tyrosine kinase receptor anaplastic lymphoma kinase (ALK) and its ligand, the growth factor pleiotrophin (PTN), are highly expressed during the development of the nervous system and have been implicated in the malignant progression of different tumor types.
Dora C Stylianou +2 more
exaly +3 more sources
A comparison of the binding sites of antibodies and single-domain antibodies
Frontiers in Immunology, 2023 Antibodies are the largest class of biotherapeutics. However, in recent years, single-domain antibodies have gained traction due to their smaller size and comparable binding affinity.
Gemma L. Gordon +5 more
doaj +3 more sources
The eIg technology to generate Ig-like bispecific antibodies
mAbs, 2022 Bispecific antibodies have emerged as therapeutic molecules with a multitude of modes of action and applications. Here, we present a novel approach to solve the light-chain problem for the generation of bispecific Ig-like antibodies using the second ...
Lennart Kühl +3 more
doaj +1 more source
Nature Communications, 2023 Bacterial AB toxins are secreted key virulence factors that are internalized by target cells through receptor-mediated endocytosis, translocating their enzymatic domain to the cytosol from endosomes (short-trip) or the endoplasmic reticulum (long-trip ...
Johnny Lisboa +12 more
doaj +1 more source
Scientific Reports, 2021 The high binding affinities and specificities of antibodies have led to their use as drugs and biosensors. Single-domain VHH antibodies exhibit high specificity and affinity but have higher stability and solubility than conventional antibodies as they ...
Emina Ikeuchi +4 more
doaj +1 more source
A Fab-Selective Immunoglobulin-Binding Domain from Streptococcal Protein G with Improved Half-Life Extension Properties. [PDF]
PLoS ONE, 2015 Half-life extension strategies have gained increasing interest to improve the pharmacokinetic and pharmacodynamic properties of protein therapeutics. Recently, we established an immunoglobulin-binding domain (IgBD) from streptococcal protein G (SpGC3) as
Felix Unverdorben +3 more
doaj +1 more source
Molecular immunolabeling with recombinant single-chain variable fragment (scFv) antibodies designed with metal-binding domains [PDF]
Proceedings of the National Academy of Sciences, 2001 To study the molecular structure and function of gene productsin situ, we developed a molecular immunolabeling technology. Starting with cDNA from hybridomas producing monoclonal antibodies against biotin, catalase, and superoxide dismutase, we bioengineered recombinant single-chain variable fragment antibodies (scFv) and their derivatives containing ...
Marek, Malecki +3 more
openaire +2 more sources
Development and evaluation of single domain antibodies for vaccinia and the L1 antigen. [PDF]
PLoS ONE, 2014 There is ongoing interest to develop high affinity, thermal stable recognition elements to replace conventional antibodies in biothreat detection assays. As part of this effort, single domain antibodies that target vaccinia virus were developed.
Scott A Walper +4 more
doaj +1 more source
Frontiers in Immunology, 2023 BackgroundSerum albumin binding is an established mechanism to extend the serum half-life of antibody fragments and peptides. The cysteine rich knob domains, isolated from bovine antibody ultralong CDRH3, are the smallest single chain antibody fragments ...
Ralph Adams +18 more
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