Selection of intracellular single-domain antibodies targeting the HIV-1 Vpr protein by cytoplasmic yeast two-hybrid system. [PDF]
PLoS ONE, 2014 The targeting of HIV-1 using antibodies is of high interest as molecular tools to better understand the biology of the virus or as a first step toward the design of new inhibitors targeting critical viral intracellular proteins.
Julie Matz +7 more
doaj +14 more sources
Single Domain Antibodies as New Biomarker Detectors [PDF]
Diagnostics, 2017 Biomarkers are defined as indicators of biological processes, pathogenic processes, or pharmacological responses to a therapeutic intervention. Biomarkers have been widely used for early detection, prediction of response after treatment, and for ...
Chiuan Herng Leow +5 more
doaj +4 more sources
A comparison of the binding sites of antibodies and single-domain antibodies [PDF]
Frontiers in Immunology, 2023 Antibodies are the largest class of biotherapeutics. However, in recent years, single-domain antibodies have gained traction due to their smaller size and comparable binding affinity.
Gemma L. Gordon +5 more
doaj +3 more sources
Species-Dependent Structural Variations in Single-Domain Antibodies [PDF]
AntibodiesBackground/Objectives: Single-domain antibodies (sdAbs) are derived from camelid heavy-chain antibodies (HCAb). Their small size, high stability, and ease of production, among other properties, makes them highly valuable in biomedical research and ...
Marta Baselga +3 more
doaj +2 more sources
Single-domain antibodies directed against hemagglutinin and neuraminidase protect against influenza B viruses [PDF]
Nature CommunicationsInfluenza B viruses are antigenically diverse and contribute significantly to the annual influenza burden. Here we report influenza B virus neutralizing single-domain antibodies that target highly conserved regions of the hemagglutinin and neuraminidase.
Arne Matthys +9 more
doaj +2 more sources
Physicochemical differences between camelid single-domain antibodies and mammalian antibodies. [PDF]
Turk J Biol, 2023 In recent years, single-domain antibodies, also known as nanobodies, have emerged as an alternative to full immunoglobulin Gs (IgGs), due to their various advantages, including increased solubility, faster clearance, and cheaper production. Nanobodies are generally derived from the variable domain of the camelid heavy-chain-only immunoglobulin Gs ...
Eskier NE +3 more
europepmc +3 more sources
Ricin Detection Using Phage Displayed Single Domain Antibodies [PDF]
Sensors, 2009 Phage-displayed single domain antibodies (sdAb) were compared to monomeric solubly expressed sdAb and llama polyclonal antibodies for the detection of ricin. SdAb are comprised of the variable domain derived from camelid heavy chain only antibodies (HcAb)
Ellen R. Goldman +5 more
doaj +3 more sources
Inhibition of tau neuronal internalization using anti-tau single domain antibodies [PDF]
Nature CommunicationsIn Alzheimer’s disease, tau pathology spreads across brain regions as the disease progresses. Intracellular tau can be released and taken up by nearby neurons.
Clément Danis +12 more
doaj +2 more sources
Single-domain antibodies as therapeutics for solid tumor treatment [PDF]
Acta Pharmaceutica Sinica BSingle-domain antibodies (sdAbs), initially identified in camelids or sharks and commonly referred to as nanobodies or VNARs, have emerged as a promising alternative to conventional therapeutic antibodies.
Mingkai Wang, Tianlei Ying, Yanling Wu
doaj +2 more sources
Single-domain antibodies for brain targeting [PDF]
, 2014 Smaller recombinant antibody fragments as single-domain antibodies (sdAbs) are emerging as credible alternatives because of their target specificity, high affinity, and cost-effective recombinant production. sdAbs have been forged into multivalent and multispecif ic therapeutics, or targeting moieties, that are able to shuttle their linked therapeutic ...
Lalatsa, Katerina, Moreira Leite, Diana
core +3 more sources