Results 1 to 10 of about 733,749 (255)

Ricin Detection Using Phage Displayed Single Domain Antibodies [PDF]

Sensors, 2009
Phage-displayed single domain antibodies (sdAb) were compared to monomeric solubly expressed sdAb and llama polyclonal antibodies for the detection of ricin. SdAb are comprised of the variable domain derived from camelid heavy chain only antibodies (HcAb)
Ellen R. Goldman, Jinny L. Liu, Rachael D. Bernstein, Stanley Q. Mitchell, Marla D. Swain, George P. Anderson   +5 more
doaj   +5 more sources

A comparison of the binding sites of antibodies and single-domain antibodies [PDF]

Frontiers in Immunology, 2023
Antibodies are the largest class of biotherapeutics. However, in recent years, single-domain antibodies have gained traction due to their smaller size and comparable binding affinity.
Gemma L. Gordon, Henriette L. Capel, Bora Guloglu, Eve Richardson, Ryan L. Stafford, Charlotte M. Deane   +5 more
doaj   +3 more sources

Single Domain Antibodies as New Biomarker Detectors [PDF]

Diagnostics, 2017
Biomarkers are defined as indicators of biological processes, pathogenic processes, or pharmacological responses to a therapeutic intervention. Biomarkers have been widely used for early detection, prediction of response after treatment, and for ...
Chiuan Herng Leow, Katja Fischer, Chiuan Yee Leow, Qin Cheng, Candy Chuah, James McCarthy   +5 more
doaj   +4 more sources

Species-Dependent Structural Variations in Single-Domain Antibodies [PDF]

Antibodies
Background/Objectives: Single-domain antibodies (sdAbs) are derived from camelid heavy-chain antibodies (HCAb). Their small size, high stability, and ease of production, among other properties, makes them highly valuable in biomedical research and ...
Marta Baselga, Javier Sánchez-Prieto, Víctor Manuel Medina Pérez, Alberto J. Schuhmacher   +3 more
doaj   +2 more sources

Single-domain antibodies directed against hemagglutinin and neuraminidase protect against influenza B viruses [PDF]

Nature Communications
Influenza B viruses are antigenically diverse and contribute significantly to the annual influenza burden. Here we report influenza B virus neutralizing single-domain antibodies that target highly conserved regions of the hemagglutinin and neuraminidase.
Arne Matthys, Jan Felix, Joao Paulo Portela Catani, Kenny Roose, Wim Nerinckx, Benthe Van Buyten, Daria Fijalkowska, Nico Callewaert, Savvas N. Savvides, Xavier Saelens   +9 more
doaj   +2 more sources

Physicochemical differences between camelid single-domain antibodies and mammalian antibodies. [PDF]

Turk J Biol, 2023
In recent years, single-domain antibodies, also known as nanobodies, have emerged as an alternative to full immunoglobulin Gs (IgGs), due to their various advantages, including increased solubility, faster clearance, and cheaper production. Nanobodies are generally derived from the variable domain of the camelid heavy-chain-only immunoglobulin Gs ...
Eskier NE, Eskier D, Firuzan E, Uzunlar SK.   +3 more
europepmc   +3 more sources

Engineering pH-Sensitive Single-Domain Antibodies. [PDF]

Methods Mol Biol, 2022
There is increasing interest in expanding an antibody beyond high affinity and specificity. One such feature is custom regulation of the binding event, such as pH-dependent control. Here, we provide a methodology for generating single-domain antibodies (sdAbs) that bind their antigen in a pH-dependent fashion.
Laughlin TM, Horn JR.
europepmc   +3 more sources

Inhibition of tau neuronal internalization using anti-tau single domain antibodies [PDF]

Nature Communications
In Alzheimer’s disease, tau pathology spreads across brain regions as the disease progresses. Intracellular tau can be released and taken up by nearby neurons.
Clément Danis, Elian Dupré, Thomas Bouillet, Marine Denéchaud, Camille Lefebvre, Marine Nguyen, Justine Mortelecque, François-Xavier Cantrelle, Jean-Christophe Rain, Xavier Hanoulle, Morvane Colin, Luc Buée, Isabelle Landrieu   +12 more
doaj   +2 more sources

Single-domain antibodies as therapeutics for solid tumor treatment [PDF]

Acta Pharmaceutica Sinica B
Single-domain antibodies (sdAbs), initially identified in camelids or sharks and commonly referred to as nanobodies or VNARs, have emerged as a promising alternative to conventional therapeutic antibodies.
Mingkai Wang, Tianlei Ying, Yanling Wu
doaj   +2 more sources

Generic semi-automated radiofluorination strategy for single domain antibodies: [18F]FB-labelled single domain antibodies for PET imaging of fibroblast activation protein-α or folate receptor-α overexpression in cancer [PDF]

EJNMMI Radiopharmacy and Chemistry
Background Radiofluorination of single domain antibodies (sdAbs) via N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB) has shown to be a promising strategy in the development of sdAb-based PET tracers. While automation of the prosthetic group (PG) [18F]SFB
Herlinde Dierick, Laurent Navarro, Hannelore Ceuppens, Thomas Ertveldt, Ana Rita Pombo Antunes, Marleen Keyaerts, Nick Devoogdt, Karine Breckpot, Matthias D’Huyvetter, Tony Lahoutte, Vicky Caveliers, Jessica Bridoux   +11 more
doaj   +2 more sources