Results 191 to 200 of about 2,953,642 (298)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Assessment of genetically modified soybean GMB151 × DAS-44406-6 (application GMFF-2024-21774, EFSA-Q-2024-00330). [PDF]

EFSA J
EFSA Panel on Genetically Modified Organisms (GMO), Casacuberta J, Barro F, Braeuning A, de Maagd R, Epstein MM, Frenzel T, Gallois JL, Koning F, Messéan A, Moreno FJ, Nogué F, Savoini G, Schulman AH, Tebbe C, Veromann E, Ardizzone M, De Sanctis G, Dumont AF, Ferrari A, Gennaro A, Gómez Ruiz JÁ, Goumperis T, Jacchia S, Kagkli DM, Lenzi P, Camargo AM, Neri FM, Raffaello T.   +28 more
europepmc   +1 more source

Time-Resolved Studies of Single-Event-Upset effects in Optical Data Receiver for the First LHC Upgrade Phase of the ATLAS Pixel Detector. [PDF]

, 2012
M. Ziolkowski
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Decision-making components and times revealed by the single-trial electroencephalogram. [PDF]

Elife
Weindel G, Borst JP, van Maanen L.
europepmc   +1 more source

Evaluation of neutron energy spectrum, fluence and single event effects of atmospheric neutron irradiation spectrometer at China spallation neutron source [PDF]

Zhi-Liang Hu, MO Lihua, Bin Zhou, YITiancheng, LI Mengchao, Z.D. Qi, Liang Tianjiao   +6 more
openalex   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Comparative assessment of endogenous lipid transfer protein (LTP) level in genetically modified maize for its relevance in safety assessment. [PDF]

GM Crops Food
Ma E, Joshi S, Birukou I, Rosenbaum E.
europepmc   +1 more source

Single event effects evaluation on convolution neural network in Xilinx 28 nm system on chip

Xu Zhao, Xuecheng Du, Xiong Xu, Chao Ma, Weitao Yang, B. Zheng, Chao Zhou   +6 more
openalex   +1 more source

Multi-scale, multi-physics modeling and simulation of single-event effects at device and circuit levels

, 2022
Jean‐Luc Autran, Daniela Munteanu
openalex   +1 more source