Results 211 to 220 of about 17,907 (258)
Reprogramming Skin Aging: A Regenerative and Epigenetic Perspective on Cutaneous Longevity
Journal of Cosmetic Dermatology, Volume 25, Issue 3, March 2026.
Diala Haykal +4 more
wiley +1 more source
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Expert Opinion on Therapeutic Patents, 2009
The sirtuin family of deacetylase enzymes comprises seven proteins (SIRT1-7) that are dependent on NAD(+) for their activity. Three proteins are located in the nucleus, three in the mitochondria and only one is predominantly cytoplasmic. Caloric restriction and oxidative stress generally up-regulate their expression. SIRT1, the orthologue of yeast Sir2,
Francisco J, Alcaín, José M, Villalba
openaire +2 more sources
The sirtuin family of deacetylase enzymes comprises seven proteins (SIRT1-7) that are dependent on NAD(+) for their activity. Three proteins are located in the nucleus, three in the mitochondria and only one is predominantly cytoplasmic. Caloric restriction and oxidative stress generally up-regulate their expression. SIRT1, the orthologue of yeast Sir2,
Francisco J, Alcaín, José M, Villalba
openaire +2 more sources
2021
Sirtuins are involved in numerous biological processes such as cell survival and metabolism, aging, and DNA repair; thus they modulate crucial metabolic pathways. The seven members of the Sirtuin family are more and more seen as potential targets for the treatment of cancer, metabolic, neurodegenerative, and cardiovascular diseases.
Zwergel, Clemens +2 more
openaire +1 more source
Sirtuins are involved in numerous biological processes such as cell survival and metabolism, aging, and DNA repair; thus they modulate crucial metabolic pathways. The seven members of the Sirtuin family are more and more seen as potential targets for the treatment of cancer, metabolic, neurodegenerative, and cardiovascular diseases.
Zwergel, Clemens +2 more
openaire +1 more source
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2010
Sirtuins have emerged as important proteins in aging, stress resistance and metabolic regulation. Three sirtuins, SIRT3, 4 and 5, are located within the mitochondrial matrix. SIRT3 and SIRT5 are NAD(+)-dependent deacetylases that remove acetyl groups from acetyllysine-modified proteins and yield 2'-O-acetyl-ADP-ribose and nicotinamide.
Jing-Yi, Huang +4 more
openaire +2 more sources
Sirtuins have emerged as important proteins in aging, stress resistance and metabolic regulation. Three sirtuins, SIRT3, 4 and 5, are located within the mitochondrial matrix. SIRT3 and SIRT5 are NAD(+)-dependent deacetylases that remove acetyl groups from acetyllysine-modified proteins and yield 2'-O-acetyl-ADP-ribose and nicotinamide.
Jing-Yi, Huang +4 more
openaire +2 more sources
Expert Opinion on Therapeutic Patents, 2009
Sirtuin 1-7 (SIRT1-7) are deacetylases that are dependent on NAD(+) for their activity. SIRT1 down-regulates p53 activity, increasing lifespan, cell survival, and neuroprotection; it also deacetylates peroxisome proliferator-activated receptor-gamma and its coactivator 1alpha, promoting fat mobilization, increasing mitochondrial size and number, and ...
Francisco J, Alcaín, José M, Villalba
openaire +2 more sources
Sirtuin 1-7 (SIRT1-7) are deacetylases that are dependent on NAD(+) for their activity. SIRT1 down-regulates p53 activity, increasing lifespan, cell survival, and neuroprotection; it also deacetylates peroxisome proliferator-activated receptor-gamma and its coactivator 1alpha, promoting fat mobilization, increasing mitochondrial size and number, and ...
Francisco J, Alcaín, José M, Villalba
openaire +2 more sources
Sirtuins in Epigenetic Regulation [PDF]
Chemical Reviews, 2015 1.1. Discovery of Sirtuins The founding member of sirtuin is the yeast-silencing information regulator 2 (SIR2) protein, one of four proteins (SIR1–4) required for silencing the mating-type information loci in yeast.1 SIR2–4, but not SIR1, are also required for gene silencing at telomeres.2 SIR2 also mediates gene silencing at the rDNA (rDNA) loci ...
Hui Jing, Hening Lin
exaly +3 more sources
2013
The nematode Caenorhabditis elegans (C. elegans) has four Sir2 paralogs, sir-2.1, sir-2.2, sir-2.3, and sir-2.4. Thus far, most of the research tools to study worm sirtuins have been developed for sir-2.1, due to its homology to yeast SIR2 and human SIRT1.
Viswanathan, Mohan, Tissenbaum, Heidi A.
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The nematode Caenorhabditis elegans (C. elegans) has four Sir2 paralogs, sir-2.1, sir-2.2, sir-2.3, and sir-2.4. Thus far, most of the research tools to study worm sirtuins have been developed for sir-2.1, due to its homology to yeast SIR2 and human SIRT1.
Viswanathan, Mohan, Tissenbaum, Heidi A.
openaire +3 more sources
Flavonoids as Sirtuin Modulators
Current Topics in Medicinal Chemistry, 2022Abstract: Sirtuins (SIRTs) are described as NAD+-dependent deacetylases, also known as class III histone deacetylases. So far, seven sirtuin genes (SIRTS 1–7) have been identified and characterized in mammals and also known to occur in bacteria and eukaryotes.
Deniz, FATMA SEZER +2 more
openaire +3 more sources