Results 11 to 20 of about 383,968 (297)

Denosumab for the prevention of skeletal complications in metastatic castration-resistant prostate cancer: comparison of skeletal-related events and symptomatic skeletal events [PDF]

Annals of Oncology, 2015
Background In a phase III trial in patients with castration-resistant prostate cancer (CRPC) and bone metastases, denosumab was superior to zoledronic acid in reducing skeletal-related events (SREs; radiation to bone, pathologic fracture, surgery to ...
Balakumaran, A., Braun, A., Chi, K.N., Coleman, R.E., Fizazi, K., Klotz, L., Milecki, P., Ng, S., Pittman, K., Smith, M.R., Wang, H., Wei, R.   +11 more
core   +4 more sources

Comparative Analyses of Two Established Scores to Assess the Stability of Spinal Bone Metastases Before and After Palliative Radiotherapy

Frontiers in Oncology, 2021
Background and PurposeTo compare two validated spinal instability scores regarding the stabilizing effects and skeletal-related events (SREs) of palliative radiotherapy (RT) in patients with spinal bone metastases (SBM).Materials and MethodsTwo hundred ...
Tilman Bostel, Tilman Bostel, Sati Akbaba, Sati Akbaba, Daniel Wollschläger, Tristan Klodt, Tristan Klodt, Laura Oebel, Laura Oebel, Arnulf Mayer, Arnulf Mayer, Sophia Drabke, Sophia Drabke, Tanja Sprave, Tanja Sprave, Jürgen Debus, Jürgen Debus, Robert Förster, Harald Rief, Alexander Rühle, Alexander Rühle, Anca-Ligia Grosu, Anca-Ligia Grosu, Heinz Schmidberger, Heinz Schmidberger, Nils H. Nicolay, Nils H. Nicolay   +26 more
doaj   +1 more source

Comparison of denosumab and zoledronic acid for the treatment of solid tumors and multiple myeloma with bone metastasis: a systematic review and meta-analysis based on randomized controlled trials

Journal of Orthopaedic Surgery and Research, 2021
Objective To compare the efficacy and safety between denosumab and zoledronic acid for advanced cancer with bone metastasis. Methods MEDLINE, EMBASE, and the Cochrane library databases were searched for randomized controlled trials up to December 2020 ...
Lianghai Jiang, Xianghua Cui, Haoning Ma, Xiangsheng Tang   +3 more
doaj   +1 more source

Denosumab: A comprehensive review

South Asian Journal of Cancer, 2013
The clinical sequelae from bone metastases, termed skeletal-related events (SREs), are among the most frequent and debilitating complications in patients with advanced cancer.
Prasad Narayanan
doaj   +1 more source

RNF219/α‐Catenin/LGALS3 Axis Promotes Hepatocellular Carcinoma Bone Metastasis and Associated Skeletal Complications

Advanced Science, 2021
The incidence of bone metastases in hepatocellular carcinoma (HCC) has increased prominently over the past decade owing to the prolonged overall survival of HCC patients. However, the mechanisms underlying HCC bone‐metastasis remain largely unknown.
Shuxia Zhang, Yingru Xu, Chan Xie, Liangliang Ren, Geyan Wu, Meisongzhu Yang, Xingui Wu, Miaoling Tang, Yameng Hu, Ziwen Li, Ruyuan Yu, Xinyi Liao, Shuang Mo, Jueheng Wu, Mengfeng Li, Erwei Song, Yanfei Qi, Libing Song, Jun Li   +18 more
doaj   +1 more source

Prevalence of skeletal-related events in hormone-naive prostate cancer in a low resource setting

Nigerian Postgraduate Medical Journal, 2022
Background: Presentation with symptoms of advanced prostate cancer is prevalent in developing societies. The objective of this study was to determine the rate of and factors associated with skeletal-related events (SREs) at presentation with hormone ...
Fredrick Obiefuna Ugwumba, Ikenna Ifeanyi Nnabugwu, Agharighom David Okoh, Kevin Ndubuisi Echetabu, Okechukwu Onwuasoigwe, Ekeoma Okey Nwosu   +5 more
doaj   +1 more source

Complications of bone metastases from malignant melanoma

Journal of Bone Oncology, 2017
Introduction: Metastatic bone disease (MBD) carries significant morbidity for patients with cancer. MBD from malignant melanoma (MM) is understudied. We examined the characteristics, morbidity, management and outcome of MBD in patients with MM.
Jamal Zekri, Maria Marples, Dominic Taylor, Kiran Kandukurti, Lucy McParland, Janet E. Brown   +5 more
doaj   +1 more source

Patterns of care and economic consequences of using bone-targeted agents for castration-sensitive prostate cancer patients with bone metastases to prevent skeletal-related events in Switzerland – the SAKK 95/16 prostate study

Swiss Medical Weekly, 2021
BACKGROUND International guidelines state that bone-targeted agents such as denosumab or zoledronic acid at doses used for bone metastasis are not indicated for patients with metastatic castration-sensitive prostate cancer (mCSPC) with bone ...
Sandro T. Stoffel, Roger von Moos, Beat Thürlimann, Richard Cathomas, Silke Gillessen, Ursina Zürrer-Härdi, Thomas von Briel, Sandro Anchisi, Anita Feller, Corinne Schär, Daniel Dietrich, Matthias Schwenkglenks, Judith E. Lupatsch, Michael Mark   +13 more
doaj   +1 more source

Effects of RANKL-Targeted Therapy in Immunity and Cancer. [PDF]

, 2014
The role of the receptor activator of nuclear factor-κB ligand (RANKL)/RANK system is well characterized within bone, where RANKL/RANK signaling mediates osteoclastogenesis and bone resorption.
Cheng, Michael L, Fong, Lawrence
core   +2 more sources

The likely effects of thermal climate change on vertebrate skeletal muscle mechanics with possible consequences for animal movement and behaviour [PDF]

, 2019
Climate change can involve alteration in the local temperature that an animal is exposed to, which in turn may affect skeletal muscle temperature.
Abrahams, Allan, Allen, Altringham, Altringham, Angilletta, Angilletta, Barany, Beever, Bennett, Bennett, Bennett, Berchtold, Bernal, Bershitsky, Brenner, Caiozzo, Chown, Colombini, Cotton, Coughlin, Coupland, Crowley, De Ruiter, Debold, Decostre, Donley, Donley, Edwards, Evans, Ferguson, Fitts, Gabriel, Glanville, Herrel, Herrel, Hertz, Higham, Hill, Hochachka, Hou, Hudson, Huey, Husak, IPCC, James, James, James, James, John-Alder, Johnson, Johnson, Johnston, Johnston, Jones, Josephson, Lailvaux, Le Roy, Mantle, Marsh, Mautz, Michelangeli, Miles, Niehaus, Nocella, Olberding, Perry, Pinder, Place, Rall, Ranatunga, Ranatunga, Ranatunga, Rand, Reilly, Rome, Roots, Rummel, Seebacher, Seebacher, Seebacher, Seebacher, Seebacher, Seebacher, Segal, Segre, Shuman, Somero, Stein, Storey, Swoap, Syme, Symonds, Vanhooydonck, Watkins, West, Wilson, Wilson, Wilson, Wilson, Wilson   +100 more
core   +1 more source