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Epigenetic control of skeletal muscle atrophy [PDF]

Cellular & Molecular Biology Letters
Skeletal muscular atrophy is a complex disease involving a large number of gene expression regulatory networks and various biological processes. Despite extensive research on this topic, its underlying mechanisms remain elusive, and effective therapeutic
Wenpeng Liang, Feng Xu, Li Li, Chunlei Peng, Hualin Sun, Jiaying Qiu, Junjie Sun   +6 more
doaj   +5 more sources

Mitochondrial dysfunction: roles in skeletal muscle atrophy

Journal of Translational Medicine, 2023
Mitochondria play important roles in maintaining cellular homeostasis and skeletal muscle health, and damage to mitochondria can lead to a series of pathophysiological changes.
Xin Chen, Yanan Ji, Ruiqi Liu, Xucheng Zhu, Kexin Wang, Xiaoming Yang, Boya Liu, Zihui Gao, Yan Huang, Yuntian Shen, Hua Liu, Hualin Sun   +11 more
doaj   +4 more sources

Potential Therapeutic Strategies for Skeletal Muscle Atrophy

Antioxidants, 2022
The maintenance of muscle homeostasis is vital for life and health. Skeletal muscle atrophy not only seriously reduces people’s quality of life and increases morbidity and mortality, but also causes a huge socioeconomic burden.
Li Huang, Ming Li, Chunyan Deng, Jiayi Qiu, Kexin Wang, Mengyuan Chang, Songlin Zhou, Yun Gu, Yuntian Shen, Wei Wang, Ziwei Huang, Hualin Sun   +11 more
doaj   +4 more sources

Epigenetics of Skeletal Muscle Atrophy. [PDF]

Int J Mol Sci
Skeletal muscle atrophy, characterized by diminished muscle strength and mass, arises from various causes, including malnutrition, aging, nerve damage, and disease-related secondary atrophy.
Du J, Wu Q, Bae EJ.
europepmc   +4 more sources

Mechanism of skeletal muscle atrophy after spinal cord injury: A narrative review

Frontiers in Nutrition, 2023
Spinal cord injury leads to loss of innervation of skeletal muscle, decreased motor function, and significantly reduced load on skeletal muscle, resulting in atrophy.
Xin Xu, Xin Xu, Xin Xu, Xin Xu, Xin Xu, Zuliyaer Talifu, Zuliyaer Talifu, Zuliyaer Talifu, Zuliyaer Talifu, Zuliyaer Talifu, Zuliyaer Talifu, Chun-Jia Zhang, Chun-Jia Zhang, Chun-Jia Zhang, Chun-Jia Zhang, Chun-Jia Zhang, Feng Gao, Feng Gao, Feng Gao, Feng Gao, Feng Gao, Han Ke, Han Ke, Han Ke, Han Ke, Han Ke, Han Ke, Yun-Zhu Pan, Yun-Zhu Pan, Yun-Zhu Pan, Yun-Zhu Pan, Yun-Zhu Pan, Yun-Zhu Pan, Han Gong, Han Gong, Han Gong, Han Gong, Han Gong, Hua-Yong Du, Hua-Yong Du, Hua-Yong Du, Hua-Yong Du, Hua-Yong Du, Yan Yu, Yan Yu, Yan Yu, Yan Yu, Ying-Li Jing, Ying-Li Jing, Ying-Li Jing, Ying-Li Jing, Liang-Jie Du, Liang-Jie Du, Liang-Jie Du, Liang-Jie Du, Liang-Jie Du, Jian-Jun Li, Jian-Jun Li, Jian-Jun Li, Jian-Jun Li, Jian-Jun Li, Jian-Jun Li, De-Gang Yang, De-Gang Yang, De-Gang Yang, De-Gang Yang, De-Gang Yang   +66 more
doaj   +2 more sources

Inflammation: Roles in Skeletal Muscle Atrophy

Antioxidants, 2022
Various diseases can cause skeletal muscle atrophy, usually accompanied by inflammation, mitochondrial dysfunction, apoptosis, decreased protein synthesis, and enhanced proteolysis.
Yanan Ji, Ming Li, Mengyuan Chang, Ruiqi Liu, Jiayi Qiu, Kexin Wang, Chunyan Deng, Yuntian Shen, Jianwei Zhu, Wei Wang, Lingchi Xu, Hualin Sun   +11 more
doaj   +3 more sources

SnapShot: Skeletal muscle atrophy.

Cell, 2022
Skeletal muscle size is highly plastic and sensitive to a variety of stimuli. Muscle atrophy occurs as the result of changes in multiple signaling pathways that regulate both protein synthesis and degradation. The signaling pathways that are activated or inhibited depend on the specific stimuli that are altered.
Leslie M. Baehr, David C. Hughes, D. Waddell, S. Bodine   +3 more
semanticscholar   +3 more sources

Regulation of skeletal muscle atrophy

Journal of Physical Fitness and Sports Medicine, 2013
Skeletal muscle atrophy can result from prolonged periods of skeletal muscle inactivity due to bed rest, denervation, or unloading. Such unloading-associated atrophy of skeletal muscle is characterized by both an increase in protein degradation and a ...
Shigetada Teshima-Kondo, Takeshi Nikawa
doaj   +3 more sources

Ubiquitin-proteasome pathway in skeletal muscle atrophy

Frontiers in Physiology, 2023
Skeletal muscles underpin myriad human activities, maintaining an intricate balance between protein synthesis and degradation crucial to muscle mass preservation.
Xiangsheng Pang, Peng Zhang, Xiaoping Chen, Wenming Liu   +3 more
semanticscholar   +4 more sources

The role of mitochondrial dynamics and mitophagy in skeletal muscle atrophy: from molecular mechanisms to therapeutic insights

Cellular & Molecular Biology Letters
Skeletal muscle is the largest metabolic organ of the human body. Maintaining the best quality control and functional integrity of mitochondria is essential for the health of skeletal muscle.
Yuhang Lei, Mailin Gan, Yanhao Qiu, Qiuyang Chen, Xingyu Wang, Tianci Liao, Mengying Zhao, Lei Chen, Shunhua Zhang, Ye Zhao, Lili Niu, Yan Wang, Li Zhu, Linyuan Shen   +13 more
doaj   +2 more sources