Results 21 to 30 of about 352,666 (292)

Cigarette Smoking Induces Skeletal Muscle Atrophy in Mice by Activated Macrophage-Mediated Pyroptosis [PDF]

Journal of Inflammation Research
Yufen Tan,1,* Yuanyuan Ye,1,* Cuibi Huang,1 Jie Li,1 Lihua Huang,1 Xinyan Wei,1 Tong Liang,1 Enyuan Qin,1 Guolin Xiong,2 Yanfei Bin1 1Department of Respiratory and Critical Care Medicine, the second Affiliated Hospital of Guangxi Medical ...
Tan Y, Ye Y, Huang C, Li J, Huang L, Wei X, Liang T, Qin E, Xiong G, Bin Y   +9 more
doaj   +1 more source

Heme oxygenase-1: A potential therapeutic target for improving skeletal muscle atrophy

Experimental Gerontology, 2023
Skeletal muscle atrophy is a common muscle disease that is directly caused by an imbalance in protein synthesis and degradation. At the histological level, it is mainly characterized by a reduction in muscle mass and fiber cross-sectional area (CSA ...
Qin Xiao, Chen-Chen Sun, Chang-Fa Tang
doaj   +1 more source

HDAC4 Knockdown Alleviates Denervation-Induced Muscle Atrophy by Inhibiting Myogenin-Dependent Atrogene Activation

Frontiers in Cellular Neuroscience, 2021
Denervation can activate the catabolic pathway in skeletal muscle and lead to progressive skeletal muscle atrophy. At present, there is no effective treatment for muscle atrophy. Histone deacetylase 4 (HDAC4) has recently been found to be closely related
Wenjing Ma, Yong Cai, Yuntian Shen, Xin Chen, Lilei Zhang, Yanan Ji, Zehao Chen, Jianwei Zhu, Xiaoming Yang, Hualin Sun   +9 more
doaj   +1 more source

Disuse-induced skeletal muscle atrophy in disease and non-disease states in humans: mechanisms, prevention, and recovery strategies.

American Journal of Physiology - Cell Physiology, 2022
Decreased skeletal muscle contractile activity (disuse) or unloading leads to muscle mass loss, also known as muscle atrophy. The balance between muscle protein synthesis (MPS) and muscle protein breakdown (MPB) is the primary determinant of skeletal ...
E. Nunes, Tanner Stokes, James McKendry, B. Currier, Stuart M Phillips   +4 more
semanticscholar   +1 more source

Prevalence and Mechanisms of Skeletal Muscle Atrophy in Metabolic Conditions

International Journal of Molecular Sciences, 2023
Skeletal muscle atrophy is prevalent in a myriad of pathological conditions, such as diabetes, denervation, long-term immobility, malnutrition, sarcopenia, obesity, Alzheimer’s disease, and cachexia.
Lauren Jun, M. Robinson, T. Geetha, T. Broderick, J. Babu   +4 more
semanticscholar   +1 more source

Exploring the Role of Oxidative Stress in Skeletal Muscle Atrophy: Mechanisms and Implications

Cureus, 2023
Skeletal muscle atrophy is a complex physiological process characterized by progressive muscle mass and strength loss. It is associated with various health conditions, including aging, disease, and certain diseases.
Suyash Agrawal, Swarupa V Chakole, Nidhi Shetty, Roshan Prasad, Tejaswee Lohakare, Mayur Wanjari   +5 more
semanticscholar   +1 more source

Inhibiting 5‐lipoxygenase prevents skeletal muscle atrophy by targeting organogenesis signalling and insulin‐like growth factor‐1

Journal of Cachexia, Sarcopenia and Muscle, 2022
Background Skeletal muscle atrophy can occur in response to numerous factors, such as ageing and certain medications, and produces a major socio‐economic burden. At present, there are no approved drugs for treating skeletal muscle atrophy. Arachidonate 5‐
Hyun‐Jun Kim, Seon‐Wook Kim, Sang‐Hoon Lee, Da‐Woon Jung, Darren R. Williams   +4 more
doaj   +1 more source

Myonectin protects against skeletal muscle dysfunction in male mice through activation of AMPK/PGC1α pathway

Nature Communications, 2023
To maintain and restore skeletal muscle mass and function is essential for healthy aging. We have found that myonectin acts as a cardioprotective myokine.
Yuta Ozaki, Koji Ohashi, Naoya Otaka, Hiroshi Kawanishi, Tomonobu Takikawa, Lixin Fang, Kunihiko Takahara, Minako Tatsumi, Sohta Ishihama, Mikito Takefuji, Katsuhiro Kato, Yuuki Shimizu, Yasuko K. Bando, Aiko Inoue, Masafumi Kuzuya, Shinji Miura, Toyoaki Murohara, Noriyuki Ouchi   +17 more
doaj   +1 more source

FOXO signaling pathway in skeletal muscle atrophy.

American Journal of Pathology, 2022
Skeletal muscle atrophy is the consequence of protein degradation exceeding protein synthesis due to disease, aging and physical inactivity. Patients with skeletal muscle atrophy have decreased muscle mass and fiber cross-sectional area, thereby ...
Kun Chen, Peng Gao, Zongchao Li, Aonan Dai, Ming Yang, Siyu Chen, Jingyue Su, Zhenhan Deng, Liangjun Li   +8 more
semanticscholar   +1 more source

Triptolide prevents LPS‐induced skeletal muscle atrophy via inhibiting NF‐κB/TNF‐α and regulating protein synthesis/degradation pathway

British Journal of Pharmacology, 2021
Increasing evidence suggests systemic inflammation‐caused skeletal muscle atrophy as a major clinical feature of cachexia. Triptolide obtained from Tripterygium wilfordii Hook F possesses potent anti‐inflammatory and immunosuppressive effects.
W. Fang, Y. Tseng, Tzu-Ying Lee, Yin-Chih Fu, Wan-Hsuan Chang, Wan-Wen Lo, Chih-Lung Lin, Y. Lo   +7 more
semanticscholar   +1 more source