Results 81 to 90 of about 352,666 (292)

Hyperglycemia induces skeletal muscle atrophy via a WWP1/KLF15 axis.

JCI Insight, 2019
Diabetes mellitus is associated with various disorders of the locomotor system including the decline in mass and function of skeletal muscle. The mechanism underlying this association has remained ambiguous, however. We now show that the abundance of the
Y. Hirata, K. Nomura, Yoko Senga, Y. Okada, Kenta Kobayashi, S. Okamoto, Y. Minokoshi, M. Imamura, S. Takeda, T. Hosooka, W. Ogawa   +10 more
semanticscholar   +1 more source

Redox Control of Proteolysis During Inactivity-Induced Skeletal Muscle Atrophy

Antioxidants and Redox Signaling, 2020
Significance: Skeletal muscles play essential roles in key body functions including breathing, locomotion, and glucose homeostasis; therefore, maintaining healthy skeletal muscles is important.
S. Powers, Mustafa Ozdemir, H. Hyatt
semanticscholar   +1 more source

Soft Actuators Integrated with Control and Power Units: Approaching Wireless Autonomous Soft Robots

Advanced Robotics Research, EarlyView.
Soft robots exhibit significant development potential in various applications. However, there are still key technical challenges regarding material improvement, structure design and components integration. This review focuses on the development and challenge of soft actuators, power components, and control components in untethered intelligent soft ...
Renwu Shi, Feifei Pan, Xiaobin Ji
wiley   +1 more source

Extracellular matrix in skeletal muscle injury and atrophy: mechanisms and therapeutic implications

Journal of Orthopaedic Translation
Extracellular matrix (ECM) is an intricate, dynamic network that is essential for structural and biochemical support of skeletal muscle cells. Upon skeletal muscle injury, ECM undergoes rapid remodeling to clear damaged tissue and provides a scaffold to ...
Xiaoyang Ge, Yesheng Jin, Jingyuan He, Zhihao Jia, Ying Liu, Yong Xu   +5 more
doaj   +1 more source

Low Levels of Serum Tryptophan Underlie Skeletal Muscle Atrophy

Nutrients, 2020
Sarcopenia is a poor prognosis factor in some cancer patients, but little is known about the mechanisms by which malignant tumors cause skeletal muscle atrophy.
Soranobu Ninomiya, Nobuhiko Nakamura, Hiroshi Nakamura, Taku Mizutani, Yuto Kaneda, Kimihiro Yamaguchi, Takuro Matsumoto, J. Kitagawa, N. Kanemura, M. Shiraki, T. Hara, M. Shimizu, H. Tsurumi   +12 more
semanticscholar   +1 more source

From Lab to Landscape: Environmental Biohybrid Robotics for Ecological Futures

Advanced Robotics Research, EarlyView.
This Perspective explores environmental biohybrid robotics, integrating living tissues, microorganisms, and insects for operation in real‐world ecosystems. It traces the leap from laboratory experiments to forests, wetlands, and urban environments and discusses key challenges, development pathways, and opportunities for ecological monitoring and ...
Miriam Filippi
wiley   +1 more source

Bulk RNA-seq of skeletal muscle reveals the role of ZBED6 in sepsis-induced muscle atrophy in minipigs

Scientific Data
Sepsis is a severe disease and induces skeletal muscle atrophy, which has a significant impact on patients. Moreover, the onset and severity of muscle atrophy can vary across different anatomical regions during sepsis.
Huan Liu, Wen Shi, Yanjun Zheng, Song Yang, Yihui Wang, Maosen Yang, Zhitao Yang, Enqiang Mao, Hanbing Shang, Erzhen Chen, Ying Chen   +10 more
doaj   +1 more source

The mechanisms of skeletal muscle atrophy in response to transient knockdown of the vitamin D receptor in vivo

Journal of Physiology, 2020
Reduced vitamin D receptor (VDR) expression prompts skeletal muscle atrophy. Atrophy occurs through catabolic processes, namely the induction of autophagy, while anabolism remains unchanged. In response to VDR‐knockdown mitochondrial function and related
J. Bass, Abid A. Kazi, C. Deane, Asif Nakhuda, Stephen P. Ashcroft, M. Brook, D. Wilkinson, B. Phillips, A. Philp, J. Tarum, F. Kadi, D. Andersen, A. M. Garcia, Ken Smith, I. Gallagher, N. Szewczyk, M. Cleasby, P. Atherton   +17 more
semanticscholar   +1 more source

Atrophic Skeletal Muscle‐Derived Extracellular Vesicles Transfer miR‐125a‐5p to Inhibit Bone Formation in Osteoporosis during Aging

Advanced Science, EarlyView.
A muscle‐bone endocrine pathway in aging is revealed in which extracellular vesicles released from atrophic skeletal muscle (Aged‐SKM‐EVs) inhibit bone formation. These EVs deliver miR‐125a‐5p to osteoblasts, thereby suppressing the SIRT7‐Sp7 signaling axis and osteogenic differentiation.
Xiaoyan Shao, Pan Zhang, Zhidan Fan, Jiaquan Lin, Xiang Chen, Na Liu, Wang Gong, Yi He, Yining Zhou, Tianshu Shi, Yong Shi, Yuze Ma, Wentian Gao, Haosheng Wang, Depeng Fang, Chengzhi Wang, Wenshu Wu, Wenjin Yan, Jianghui Qin, Dongyang Chen, Haiguo Yu, Qing Jiang, Baosheng Guo   +22 more
wiley   +1 more source

The mechanisms and treatments of muscular pathological changes in immobilization-induced joint contracture: A literature review

Chinese Journal of Traumatology, 2019
The clinical treatment of joint contracture due to immobilization remains difficult. The pathological changes of muscle tissue caused by immobilization-induced joint contracture include disuse skeletal muscle atrophy and skeletal muscle tissue fibrosis ...
Feng Wang, Quan-Bing Zhang, Yun Zhou, Shuang Chen, Peng-Peng Huang, Yi Liu, Yuan-Hong Xu   +6 more
doaj   +1 more source